Results 41 to 50 of about 2,823,744 (183)

Structure and function of bacterial dynamin-like proteins [PDF]

, 2012
Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
core   +1 more source

Roles of Rap1 signaling in tumor cell migration and invasion

Cancer Biology & Medicine, 2017
Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization.
Yi-Lei Zhang, Ruo-Chen Wang, Ken Cheng, Brian Z. Ring, Li Su   +4 more
doaj   +1 more source

RhoA and Rac1 in Liver Cancer Cells: Induction of Overexpression Using Mechanical Stimulation

Micromachines, 2020
Liver cancer, especially hepatocellular carcinoma (HCC), is an aggressive disease with an extremely high mortality rate. Unfortunately, no promising markers are currently available for the early diagnosis of this disease.
Sharda Yadav, Navid Kashaninejad, Nam-Trung Nguyen   +2 more
doaj   +1 more source

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients

Clinical Proteomics, 2012
Background Pathogenesis of liver damage in patients with HIV and HCV co-infection is complex and multifactorial. Although global awareness regarding HIV-1/HCV co-infection is increasing little is known about the pathophysiology that mediates the rapid ...
Boukli Nawal M, Shetty Vivekananda, Cubano Luis, Ricaurte Martha, Coelho-dos-Reis Jordana, Nickens Zacharie, Shah Punit, Talal Andrew H, Philip Ramila, Jain Pooja   +9 more
doaj   +1 more source

Cell Division Control Protein 42 Interacts With Hepatitis E Virus Capsid Protein and Participates in Hepatitis E Virus Infection

Frontiers in Microbiology, 2021
Hepatitis E Virus (HEV) causes viral hepatitis in humans worldwide, while a subset of HEV species, avian HEV, causes hepatitis-splenomegaly syndrome in chickens.
Mengnan Fan, Yuhang Luo, Beibei Zhang, Jiaxi Wang, Tianxiang Chen, Baoyuan Liu, Yani Sun, Yuchen Nan, Julian A. Hiscox, Qin Zhao, En-Min Zhou   +10 more
doaj   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Analysis of Rho GTPase signalling pathways regulating epithelial morphogenesis [PDF]

, 2010
Rho GTPases are molecular switches controlling many aspects of cell behaviour, including cell cycle progression, cell division, migration and morphology. The activity of Rho proteins is regulated by conformational changes induced by binding of guanine
Wallace, S.
core  

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Host Defense Peptide LL-37-Mediated Chemoattractant Properties, but Not Anti-Inflammatory Cytokine IL-1RA Production, Is Selectively Controlled by Cdc42 Rho GTPase via G Protein-Coupled Receptors and JNK Mitogen-Activated Protein Kinase

Frontiers in Immunology, 2018
The human host defense peptide LL-37 promotes immune activation such as induction of chemokine production and recruitment of leukocytes. Conversely, LL-37 also mediates anti-inflammatory responses such as production of anti-inflammatory cytokines, e.g ...
Mahadevappa Hemshekhar, Ka-Yee Grace Choi, Ka-Yee Grace Choi, Neeloffer Mookherjee, Neeloffer Mookherjee   +4 more
doaj   +1 more source