A Process Model of Rho GTP-binding Proteins in the Context of Phagocytosis
FBTC@CONCUR, 2009 Rho GTP-binding proteins play a key role as molecular switches in many cellular activities. In response to extracellular stimuli and with the help of regulators (GEF, GAP, Effector, GDI), these proteins serve as switches that interact with their ...
L. Cardelli +2 more
semanticscholar +1 more source
PLoS ONE, 2022 Small RHO-type G-proteins act as signaling hubs and master regulators of polarity in eukaryotic cells. Their activity is tightly controlled, as defective RHO signaling leads to aberrant growth and developmental defects.
Lukas Weiß +10 more
doaj +1 more source
Cell, 1995 c-Jun amino-terminal kinases (JNKs) and mitogen-activated protein kinases (MAPKs) are closely related; however, they are independently regulated by a variety of environmental stimuli.
O. Coso +7 more
semanticscholar +1 more source
Regulation of the small GTP‐binding protein Rho by cell adhesion and the cytoskeleton [PDF]
The EMBO Journal, 1999 Soluble factors from serum such as lysophosphatidic acid (LPA) are thought to activate the small GTP-binding protein Rho based on their ability to induce actin stress fibers and focal adhesions in a Rho-dependent manner. Cell adhesion to extracellular matrices (ECM) has also been proposed to activate Rho, but this point has been controversial due to ...
X D, Ren, W B, Kiosses, M A, Schwartz
openaire +2 more sources
Computer vision profiling of neurite outgrowth mordphodynamics reveals spatio-temporal modularity of Rho GTPase signaling [PDF]
, 2014 Neurite outgrowth is essential to build the neuronal processes that produce axons and dendrites that connect the adult brain. In cultured cells, the neurite outgrowth process is highly dynamic, and consists of a series of repetitive morphogenetic sub ...
Fusco, Ludovico
core +1 more source
Bio-Protocol, 2019 In our recently published paper, we highlight that during normal aging of C. elegans age-dependent aggregates of proteins form and lead to functional decline of tissues. The protocol described here details the isolation of two proteins from C. elegans in
Amberley Stephens +2 more
doaj +1 more source
Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology. [PDF]
PLoS ONE, 2013 Rho-associated coiled coil containing protein kinase (Rho-kinase or Rock) is a well-defined determinant of actin organization and dynamics in most animal cells characterized to date.
Swarna Mohan +9 more
doaj +1 more source
RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific [PDF]
, 2004 Hypoxia induces vasoconstriction of pulmonary arteries through contraction of smooth muscle cells (SMCs). The GTPase RhoA regulates smooth muscle contractility and actin cytoskeletal remodeling through the Rho-associated kinase ( ROCK).
Bailly, K +6 more
core +1 more source
Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes [PDF]
, 2006 Peer ...
Pokhilko, Alexandra V +5 more
core +1 more source
BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility [PDF]
, 2006 Background The reciprocal (9;22) translocation fuses the bcr (breakpoint cluster region) gene on chromosome 22 to the abl (Abelson-leukemia-virus) gene on chromosome 9.
Martin Ruthardt +14 more
core +1 more source