Results 11 to 20 of about 61,508 (249)

Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI [PDF]

Cell, 2000
The RhoGDI proteins serve as key multifunctional regulators of Rho family GTP-binding proteins. The 2.6 A X-ray crystallographic structure of the Cdc42/RhoGDI complex reveals two important sites of interaction between GDI and Cdc42. First, the amino-terminal regulatory arm of the GDI binds to the switch I and II domains of Cdc42 leading to the ...
Richard Cerione, Nicolas Nassar, N Nassar   +2 more
exaly   +5 more sources

Interaction of recombinant rho A GTP‐binding proteins with photoexcited rhodopsin [PDF]

FEBS Letters, 1990
The small molecular mass GTP‐binding proteins rho A, B and C are targets for ADP‐ribosyltransferase activity of the botulinum exoenzyme C3. The possible interaction of recombinant rho A proteins expressed in E. coli with photoexcited rhodopsin was studied by reconstitution with bovine rod outer segment (ROS) membranes depleted of endogenous GTP‐binding
Wieland, Thomas, Ulibarri, Isabel, Gierschik, Peter, Hall, Alan, Aktories, Klaus, Jakobs, Karl H.   +5 more
openaire   +4 more sources

Direct Involvement of the Small GTP-binding Protein Rho in lbc Oncogene Function [PDF]

Journal of Biological Chemistry, 1995
The lbc oncogene is tumorigenic in nude mice, transforms NIH 3T3 fibroblasts, and encodes a Dbl homology domain found in several transforming gene products including the dbl oncogene product. While both lbc- and dbl-transformed NIH 3T3 foci exhibited a comparable gross appearance, lbc-transformed cell morphology was clearly distinct from that of dbl ...
Y, Zheng, M F, Olson, A, Hall, R A, Cerione, D, Toksoz   +4 more
openaire   +4 more sources

Toxin-induced activation of Rho GTP-binding protein increases Bcl-2 expression and influences mitochondrial homeostasis. [PDF]

Experimental Cell Research, 1998
It is now well established that apoptosis plays a pivotal role in several physiological and pathological situations. Consequently, the mechanisms controlling the cell fate are currently the subject of intense investigation.
C. Fiorentini, P. Matarrese, E. Straface, L. Falzano, A. Fabbri, G. Donelli, A. Cossarizza, P. Boquet, W. Malorni   +8 more
semanticscholar   +2 more sources

Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity

Frontiers in Cardiovascular Medicine, 2022
Platelet cytoskeletal reorganisation is a critical component of platelet activation and thrombus formation in haemostasis. The Rho GTPases RhoA, Rac1 and Cdc42 are the primary drivers in the dynamic reorganisation process, leading to the development of ...
Shane P. Comer, Shane P. Comer
doaj   +1 more source

Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases

Cells, 2021
Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking. Acting as molecular switches, the function of Rho GTPases is determined by guanosine triphosphate (GTP)/guanosine diphosphate (GDP) exchange and their lipidation
Rashmita Pradhan, Phuong A. Ngo, Luz d. C. Martínez-Sánchez, Markus F. Neurath, Rocío López-Posadas   +4 more
doaj   +1 more source

Thrombopoietin and collagen in low doses cooperatively induce human platelet activation

Acute Medicine & Surgery, 2022
Aim In acute medicine, we occasionally treat life‐threatening conditions such as sepsis and trauma, which cause severe thrombocytopenia. Serum thrombopoietin levels have been reported to increase under the condition of thrombocytopenia related to ...
Tomoaki Doi, Takamitsu Hori, Takashi Onuma, Daisuke Mizutani, Kyohei Ueda, Yukiko Enomoto, Rie Matsushima‐Nishiwaki, Kumiko Tanabe, Tomoyuki Hioki, Haruhiko Tokuda, Toru Iwama, Hiroki Iida, Osamu Kozawa, Shinji Ogura   +13 more
doaj   +1 more source

Visualizing the subcellular localization of RHOB-GTP and GTPase-Effector complexes using a split-GFP/nanobody labelling assay

European Journal of Cell Biology, 2023
Small GTPases are highly regulated proteins that control essential signaling pathways through the activity of their effector proteins. Among the RHOA subfamily, RHOB regulates peculiar functions that could be associated with the control of the endocytic ...
Sebastian Castillo, Rémi Gence, Delphine Pagan, Faten Koraïchi, Catherine Bouchenot, Benoit J. Pons, Betty Boëlle, Aurélien Olichon, Isabelle Lajoie-Mazenc, Gilles Favre, Jean-Denis Pédelacq, Stéphanie Cabantous   +11 more
doaj   +1 more source

TRP Channels Regulation of Rho GTPases in Brain Context and Diseases

Frontiers in Cell and Developmental Biology, 2020
Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood ...
Boris Lavanderos, Boris Lavanderos, Ian Silva, Ian Silva, Pablo Cruz, Pablo Cruz, Octavio Orellana-Serradell, Octavio Orellana-Serradell, María Paz Saldías, María Paz Saldías, Oscar Cerda, Oscar Cerda, Oscar Cerda   +12 more
doaj   +1 more source

Identification of potential small molecule binding pockets on Rho family GTPases. [PDF]

PLoS ONE, 2012
Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activity is
Juan Manuel Ortiz-Sanchez, Sara E Nichols, Jacqueline Sayyah, Joan Heller Brown, J Andrew McCammon, Barry J Grant   +5 more
doaj   +1 more source