Results 61 to 70 of about 2,823,744 (183)
Loss of RhoB expression enhances the myelodysplastic phenotype of mammalian diaphanous-related Formin mDia1 knockout mice. [PDF]
PLoS ONE, 2009 Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis and hyperplastic bone marrow. Complete loss or interstitial deletions of the long arm of chromosome 5 occur frequently in MDS.
Aaron D DeWard +4 more
doaj +1 more source
Targeting KRAS for cancer therapy
British Journal of Pharmacology, EarlyView.In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia +4 more
wiley +1 more source
, 2011 GTPases act as molecular switches to control many cellular processes, including signalling, protein translation and targeting. Switch activity can be regulated by external effector proteins or intrinsic properties, such as dimerization.
Ivo Tews +19 more
core +1 more source
Rabaptin5 is recruited to endosomes by Rab4a and Rabex5 to regulate endosome maturation [PDF]
, 2014 Membrane trafficking between organelles is fundamental to the existence of eukaryotic cells. A multitude of proteins is involved in membrane trafficking, acting as building blocks for transport carriers, regulators of transport, and targeting and fusion ...
Kälin, Simone
core +1 more source
Highly effective non-viral gene transfer into vascular smooth muscle cells of cultured resistance arteries demonstrated by genetic inhibition of sphingosine-1-phosphate-induced vasoconstriction [PDF]
, 2003 The linkage of vascular genes to specific functions will lead to a better understanding of cardiovascular pathophysiology. We developed an experimental model that enables the introduction of one or multiple gene(s) into vascular smooth muscle cells ...
Pohl, U., Bolz, S. S.
core +2 more sources
Rho GTPase and Rho Kinase Signaling in Tissue Contractility and Intraocular Pressure Regulation
Frontiers in Bioscience-LandmarkThe Rho GTPase and Rho kinase (ROCK) signaling pathway is essential for cellular mechanics, acting as key regulators of the actin cytoskeleton and actomyosin contractility in various cell types and tissues. Rho GTPases, functioning as molecular switches,
Srimathi Raghavan +1 more
doaj +1 more source
Topological and functional properties of the small GTPases protein interaction network. [PDF]
PLoS ONE, 2012 Small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) regulate key cellular processes such as signal transduction, cell proliferation, cell motility, and vesicle transport.
Anna Delprato
doaj +1 more source
M1 macrophage‐derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axis
Journal of Diabetes Investigation, EarlyView.ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. The specific role of M1 macrophage‐derived exosomes in DN progression remains largely unexplored. Methods THP‐1 monocytes were differentiated into M0 macrophages and polarized into M1 macrophages for exosome extraction.
Lei Li +5 more
wiley +1 more source
Rac and Rho GTPases in cancer cell motility control
Cell Communication and Signaling, 2010 Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation.
Parri Matteo, Chiarugi Paola
doaj +1 more source
Molecular Microbiology, EarlyView.A run of consecutive fast‐translated codons (right) within the first 30 codons of lacZ (top) causes loss of the downstream transcript at positions coinciding with previously mapped intragenic Rho‐dependent termination sites (middle), and a corresponding loss of β‐galactosidase activity (bottom).
Steen Pedersen +5 more
wiley +1 more source