Results 81 to 90 of about 61,508 (249)

Subcellular distribution and membrane association of Rho-related small GTP-binding proteins in kidney cortex [PDF]

, 1995
We have examined the subcellular distribution of Rho-related small GTP-binding proteins in the kidney. RhoA, CDC42, and Rac1 small GTP-binding proteins were found to be expressed at high levels in rat outer kidney cortex.
R. Beliveau, D. Boivin
core   +1 more source

Function and regulation of Rnd proteins in cortical projection neuron migration

Frontiers in Neuroscience, 2015
The mammalian cerebral cortex contains a high variety of neuronal subtypes that acquire precise spatial locations and form long or short-range connections to establish functional neuronal circuits.
Roberta eAzzarelli, Francois eGuillemot, Emilie ePacary, Emilie ePacary   +3 more
doaj   +1 more source

Plant G proteins: Versatile signaling hubs for synergistic improvement of agronomic traits

Journal of Integrative Plant Biology, EarlyView.
This review highlights the roles of G‐protein signaling in crop yield and quality, as well as abiotic and biotic stress responses. It also discusses the feasibility of breaking the trade‐off between plant growth and stress tolerance via dissecting G‐protein regulatory pathways, gene editing, mining natural elite variants, and AI‐assisted breeding ...
Haoran Li, Zhilong Zhang, Fangyuan Liu, Haonan Wang, Zebiao He, Sanyuan Tang, Xiaojing Dong, Peng Xie   +7 more
wiley   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

K-Ras mediated murine epidermal tumorigenesis Is dependent upon and associated with elevated Rac1 activity [PDF]

, 2011
A common goal for potential cancer therapies is the identification of differences in protein expression or activity that would allow for the selective targeting of tumor vs. normal cells. The Ras proto-oncogene family (K-Ras, H-Ras and N-Ras) are amongst
Samuel, M., Lourenco, F., Michael S Samuel, Filipe C Lourenço, Olson, M.F., Michael F Olson, Filipe C. Lourenço, Samuel Michael S., Olson Michael F., Samuel, M.S., Lourenço, F.C., Michael S. Samuel, Lourenço Filipe C., Olson, M., Michael F. Olson   +14 more
core   +1 more source

Loss of RhoB expression enhances the myelodysplastic phenotype of mammalian diaphanous-related Formin mDia1 knockout mice. [PDF]

PLoS ONE, 2009
Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis and hyperplastic bone marrow. Complete loss or interstitial deletions of the long arm of chromosome 5 occur frequently in MDS.
Aaron D DeWard, Kellie Leali, Richard A West, George C Prendergast, Arthur S Alberts   +4 more
doaj   +1 more source

Autophagy in MASLD: A Metabolic and Precision Medicine Perspective

Liver International, Volume 46, Issue 9, September 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common chronic liver condition worldwide and a major contributor to cirrhosis and hepatocellular carcinoma (HCC). While metabolic triggers such as obesity and insulin resistance are key drivers of MASLD, growing evidence has identified defects in intracellular quality
Alessandra Cazzaniga, Silvia Frigo, Alessandro Cherubini, Eniada Rrapaj, Luca Valenti   +4 more
wiley   +1 more source

Effect of lovastatin on small GTP binding proteins and on TGF-β1 and fibronectin expression [PDF]

, 2000
Effect of lovastatin on small GTP binding proteins and on TGF-β1 and fibronectin expression. We have shown that lovastatin, an inhibitor of 3 hydroxy-3-methylglutary coenzyme A (HMG CoA) reductase, delays development and progression of diabetic ...
Kim, Hey Jin, Han, Dong Cheol, Kim, Sung Il, Lee, Hi Bahl   +3 more
core   +1 more source

Rho GTPase and Rho Kinase Signaling in Tissue Contractility and Intraocular Pressure Regulation

Frontiers in Bioscience-Landmark
The Rho GTPase and Rho kinase (ROCK) signaling pathway is essential for cellular mechanics, acting as key regulators of the actin cytoskeleton and actomyosin contractility in various cell types and tissues. Rho GTPases, functioning as molecular switches,
Srimathi Raghavan, Padmanabhan P Pattabiraman   +1 more
doaj   +1 more source

Topological and functional properties of the small GTPases protein interaction network. [PDF]

PLoS ONE, 2012
Small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) regulate key cellular processes such as signal transduction, cell proliferation, cell motility, and vesicle transport.
Anna Delprato
doaj   +1 more source