Results 101 to 110 of about 56,819 (220)

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

A Rho family GTPase controls actin dynamics and tip growth via two counteracting downstream pathways in pollen tubes. [PDF]

, 2005
Tip growth in neuronal cells, plant cells, and fungal hyphae is known to require tip-localized Rho GTPase, calcium, and filamentous actin (F-actin), but how they interact with each other is unclear.
Dowd, Peter, Fu, Ying, Gilroy, Simon, Gu, Ying, Li, Shundai, Vernoud, Vanessa, Yang, Zhenbiao   +6 more
core   +3 more sources

Sphingosine‐1‐Phosphate Receptor 3 Confers Tumor Metastasis in Lung Cancer Resistant to Third‐Generation EGFR Inhibitor

MedComm, Volume 7, Issue 5, May 2026.
• S1PR3 drives metastasis in EGFR TKI‐resistant lung cancer by activating RAC1‐PAK1 signaling and promoting EMT. • FGFR1‐STAT4 axis upregulates S1PR3, enabling metastatic escape in resistant tumors. • Targeting S1PR3 or FGFR1 suppresses metastasis, offering a therapeutic strategy for EGFR TKI‐resistant lung cancer.
Mengzhen Lai, Jiaying Chen, Ye Qin, Hui Zhang, Zilu Pan, Tao Zhang, Linjiang Tong, Haotian Tang, Gang Bai, Qiupei Liu, Yan Li, Fang Feng, Peiran Song, Yingqiang Liu, Yi Chen, Yan Fang, Bencan Tang, Meiyu Geng, Ker Yu, Hao Chen, Jian Ding, Hua Xie   +21 more
wiley   +1 more source

Discovering the therapeutic potential of Naringenin in diabetes related to GLUT-4 and its regulatory factors: A computational approach

Chemical Physics Impact
This study explores the therapeutic potential of Naringenin, a natural flavonoid, in managing Type 2 Diabetes Mellitus (T2DM) by focusing on Glucose Transporter 4 (GLUT4) and related regulatory proteins that play a role in glucose and lipid metabolism ...
Ali Khakpour, Shamim Ghiabi, Ali Kazemi Babaheydari, Seyedeh Atefeh Mirahmadi, Payam Baziyar, Ehsan Heidari-Soureshjani, Mohammad Karami Horestani   +6 more
doaj   +1 more source

Phosphatidylserine polarization is required for proper Cdc42 localization and for development of cell polarity. [PDF]

, 2010
We used genetically-encoded fluorescent probes to visualize the distribution of phosphatidylserine (PS) in live S. cerevisiae. The majority of the PS was found to reside in the cytosolic leaflet of the plasma membrane.
Gregory Fairn, Sergio Grinstein
core   +1 more source

Distinct CED-10/Rac1 domains confer context-specific functions in development.

PLoS Genetics, 2018
Rac GTPases act as master switches to coordinate multiple interweaved signaling pathways. A major function for Rac GTPases is to control neurite development by influencing downstream effector molecules and pathways.
Steffen Nørgaard, Shuer Deng, Wei Cao, Roger Pocock   +3 more
doaj   +1 more source

Protein Pattern Formation

, 2018
Protein pattern formation is essential for the spatial organization of many intracellular processes like cell division, flagellum positioning, and chemotaxis.
A Desai, A Melbinger, A Touhami, A Treuner-Lange, A Varma, A-C Butty, AB Goryachev, AG Vecchiarelli, AJ Molendijk, AM Turing, B Goldstein, B Klünder, BD Corbin, D Schumacher, D Thalmeier, DA Ramirez-Diaz, David Fange, DM Raskin, DM Raskin, E Bi, E Mileykovskaya, E Munro, F Wu, Fabai Wu, FO Bendezu, G Bange, G Meacci, I Bose, IS Aranson, J Denk, J Denk, J Guckenheimer, J Halatek, J Halatek, J Halatek, J Halatek, J Lutkenhaus, J Lutkenhaus, J Männik, J Schweizer, JE Pearson, JS Schuhmacher, K Gerdes, K Zieske, K Zieske, K Zieske, K-T Park, KC Huang, KJ Lee, L Kozubowski, L Laan, L Reese, L Reese, LA Segel, LD Renner, LL Lackner, M Bonny, M Cross, M Kac, M Loose, M Loose, M Loose, M Loose, M Otsuji, MC Florian, NW Goehring, NW Goehring, NW Goehring, O Sliusarenko, P Gray, P Gray, P Gray, R Thom, R Wedlich-Soldner, RA Green, S Bergeler, S Kondo, S Kretschmer, T Freisinger, TH Szeto, V Ivanov, V Varga, V Varga, WM Bement, Y Caspi, Y Gu, Y-L Shih, Y-L Shih, Y-L Shih, Z Hu, Z Hu, Z Hu, Z Hu, Z Hu   +93 more
core   +1 more source

Tasco®, a Product of Ascophyllum nodosum, Imparts Thermal Stress Tolerance in Caenorhabditis elegans

Marine Drugs, 2011
Tasco®, a commercial product manufactured from the brown alga Ascophyllum nodosum, has been shown to impart thermal stress tolerance in animals. We investigated the physiological, biochemical and molecular bases of this induced thermal stress tolerance ...
Franklin Evans, Balakrishnan Prithiviraj, Alan T. Critchley, Wajahatullah Khan, Jatinder Singh Sangha, Di Fan, Saveetha Kandasamy   +6 more
doaj   +1 more source

Galpha 12 and Galpha 13 Are Phosphorylated during Platelet Activation [PDF]

, 1996
The ubiquitously expressed G-proteins G12 and G13 whose function is currently not clear have been shown to be activated in platelet membranes through receptors that stimulate platelet aggregation. We used intact human platelets to determine whether alpha
Hu, Yi-Hui, Offmanns, Stefan, Simon, Melvin I.   +2 more
core  

Functional specialization of the yeast Rho1 GTP exchange factors [PDF]

, 2012
Rho GTPases are regulated in complex spatiotemporal patterns that may be dependent, in part at least, on the multiplicity of their GTP exchange factors (GEFs).
Cundell, M., Gray, J., Johnston, G., Krause, S., McGhie, J., Poon, P., Price, C.   +6 more
core