BMC CancerBackground The Rho GTPase-activating protein (RhoGAP) family represents a large and diverse group of proteins that act as key regulators of Rho GTPases, small GTP-binding proteins involved in cellular signaling. Tight regulation of Rho GTPase activity is
Ke Tan +7 more
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Review of cellular and molecular pathways linking thrombosis and innate immune system during sepsis
Journal of Research in Medical Sciences, 2010 Cellular and molecular pathways link thrombosis and innate immune system during sepsis. Extrinsic pathway activation of protease thrombin through FVIIa and tissue factor (TF) in sepsis help activate its endothelial cell (EC) membrane Protease Activated ...
Filip A Konecny
doaj
Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. [PDF]
, 2004 Insulin stimulation of adipocytes resulted in the recruitment of atypical PKC (PKCzeta/lambda) to plasma membrane lipid raft microdomains. This redistribution of PKCzeta/lambda was prevented by Clostridium difficile toxin B and by cholesterol depletion ...
Hwang, Joseph B +4 more
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Genome-Wide Analysis of Gene and Protein Expression of Dysplastic Naevus Cells
Journal of Skin Cancer, 2012 Cutaneous melanoma, a type of skin tumor originating from melanocytes, often develops from premalignant naevoid lesions via a gradual transformation process driven by an accumulation of (epi)genetic lesions.
Linda Gao +7 more
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Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. [PDF]
, 2002 We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps in a signal transduction cascade that lead to NFkappaB activation and collagenase-1 (CL-1)/matrix ...
Werb, Zena, Werner, Erica
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PACAP induces FSHβ gene expression via EPAC. [PDF]
, 2019 Gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are heterodimers of a common α subunit and unique β subunits. Regulation of their levels, primarily by GnRH, is critical for reproductive function.
Coss, Djurdjica, Yeh, Debra M
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CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. [PDF]
, 1995 Cdc42 and Rac1 are members of the rho family of small guanosinetriphosphatases and are required for a diverse set of cytoskeleton-membrane interactions in different cell types.
Auvinen, P +4 more
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Full-length RNA-Seq of the RHOH gene in human B cells reveals new exons and splicing patterns
Scientific ReportsThe RhoH protein is a member of the Ras superfamily of guanosine triphosphate-binding proteins. RhoH is an atypical Rho family member that is always GTP-bound and thus always activated.
Frédéric Leprêtre +7 more
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Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs. [PDF]
, 2019 Proper axonal growth and guidance is essential for neuron differentiation and development. Abnormal neuronal development due to genetic or epigenetic influences can contribute to neurological and mental disorders such as Down syndrome, Rett syndrome, and
Almenar-Queralt, Angels +8 more
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