Results 111 to 120 of about 61,508 (249)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, Volume 13, Issue 39, 13 July 2026.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

ADP-ribosylation of Rho proteins inhibits sperm motility [PDF]

, 1993
The highly homologous Rho proteins RhoA, RhoB and RhoC are low-molecular-mass GTP-binding proteins. They are selectively ADP-ribosylated by Clostridium botulinum ADP-ribosyltransferase C3 (C3 exoenzyme).
Habermann, Barbara, Just, Ingo, Schill, Wolf-Bernhard, Aktories, Klaus, Hinsch, Klaus-Dieter, Hinsch, Elvira, Pfisterer, Susanne   +6 more
core   +1 more source

Complex interplay between RAS GTPases and RASSF effectors regulates subcellular localization of YAP

EMBO Reports
RAS GTPases bind effectors to convert upstream cues to changes in cellular function. Effectors of classical H/K/NRAS are defined by RBD/RA domains which recognize the GTP-bound conformation of these GTPases, yet the specificity of RBD/RAs for over 160 ...
Swati Singh, Gabriela Bernal Astrain, Ana Maria Hincapie, Marilyn Goudreault, Matthew J Smith   +4 more
doaj   +1 more source

Regulation of Cdc42 for polarized growth in budding yeast

Microbial Cell, 2020
The Rho GTPase Cdc42 is a central regulator of cell polarity in diverse cell types. The activity of Cdc42 is dynamically controlled in time and space to enable distinct polarization events, which generally occur along a single axis in response to spatial
Kristi E. Miller, Pil Jung Kang, Hay-Oak Park   +2 more
doaj   +1 more source

Clostridium difficile toxin B acts on the GTP-binding protein Rho.

Journal of Biological Chemistry, 1994
Clostridium difficile toxin B exhibits cytotoxic activity that is characterized by the disruption of the microfilamental cytoskeleton. Here we studied whether the GTP-binding Rho protein, which reportedly participates in the regulation of the actin cytoskeleton, is involved in the toxin action. Toxin B treatment of Chinese hamster ovary cells reveals a
I, Just, G, Fritz, K, Aktories, M, Giry, M R, Popoff, P, Boquet, S, Hegenbarth, C, von Eichel-Streiber   +7 more
openaire   +2 more sources

A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction

Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1836-1870, July 2026.
ABSTRACT In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficiency and integrity, are essential but mechanistically complex. This study presents a modular mechanistic model of the IVT process to advance scientific understanding ...
Keqi Wang, Keilung Choy, Eli Reiser, Jinxiang Pei, Hua Zheng, Aparajita Dasgupta, Fuqiang Cheng, Guogang Dong, Bhanu Chandra Mulukutla, Joshua Mannheimer, Carolyn Huang, Hooman Farsani, Wei Xie   +12 more
wiley   +1 more source

Cloning and characterisation of genes determining pod morphology in pea [PDF]

, 1994
Genes expressed in developing pea pods were isolated as cDNAs by differential screening techniques. The cDNAs were characterised by DNA sequencing and expression studies were used to investigate the role of isolated cDNAs in pod development.
Drew, J.E, Drew, Janice Elizabeth
core  

14-3-3-Pred:Improved methods to predict 14-3-3-binding phosphopeptides [PDF]

, 2015
Motivation: The 14-3-3 family of phosphoprotein-binding proteins regulate many cellular processes by docking onto pairs of phosphorylated Ser and Thr residues in a constellation of intracellular targets. Therefore, there is a pressing need to develop new
Murugesan, Gavuthami, Madeira, Fábio, Cole, Christian; id_orcid, Stafford, Margaret, Toth, Rachel, Barton, Geoffrey J.; id_orcid, Tinti, Michele, Berrett, Emily, MacKintosh, Carol; id_orcid   +8 more
core   +1 more source

Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice

Frontiers in Molecular Neuroscience, 2018
ARHGEF6 belongs to the family of guanine nucleotide exchange factors (GEFs) for Rho GTPases, and it specifically activates Rho GTPases CDC42 and RAC1.
Chengwen Zhu, Chengwen Zhu, Chengwen Zhu, Cheng Cheng, Cheng Cheng, Cheng Cheng, Cheng Cheng, Yanfei Wang, Yanfei Wang, Waqas Muhammad, Waqas Muhammad, Shuang Liu, Weijie Zhu, Buwei Shao, Zhong Zhang, Xiaoqian Yan, Qingqing He, Zhengrong Xu, Chenjie Yu, Xiaoyun Qian, Ling Lu, Shasha Zhang, Shasha Zhang, Shasha Zhang, Shasha Zhang, Yuan Zhang, Wei Xiong, Xia Gao, Xia Gao, Zhigang Xu, Zhigang Xu, Renjie Chai, Renjie Chai, Renjie Chai, Renjie Chai, Renjie Chai   +35 more
doaj   +1 more source

Differential Expression of Distinct Members of Rho Family GTP-Binding Proteins during Neuronal Development: Identification ofRac1B, a New Neural-Specific Member of the Family

Journal of Neuroscience, 1997
Previous studies on small GTP-binding proteins of the Rho family have revealed their involvement in the organization of cell actin cytoskeleton. The function of these GTPases during vertebrate development is not known.
M. Malosio, D. Gilardelli, Simona Paris, C. Albertinazzi, I. de Curtis   +4 more
semanticscholar   +1 more source