Results 91 to 100 of about 61,508 (249)
The Small GTP-Binding Protein Rho Potentiates AP-1 Transcription in T Cells [PDF]
Molecular and Cellular Biology, 1998 The Rho family of small GTP-binding proteins is involved in the regulation of cytoskeletal structure, gene transcription, specific cell fate development, and transformation. We demonstrate in this report that overexpression of an activated form of Rho enhances AP-1 activity in Jurkat T cells in the presence of phorbol myristate acetate (PMA), but ...
J H, Chang +4 more
openaire +2 more sources
Animal Genetics, Volume 57, Issue 4, August 2026.ABSTRACT This study aimed to investigate how maternal feed restriction at different gestational stages alters the expression of novel long non‐coding RNAs (lncRNAs) in the skeletal muscle of goat offspring. LncRNAs are emerging as important regulators of biological processes, including myogenesis, yet their role in fetal programming remains largely ...
Maria M. M. Muniz +8 more
wiley +1 more source
Highly effective non-viral gene transfer into vascular smooth muscle cells of cultured resistance arteries demonstrated by genetic inhibition of sphingosine-1-phosphate-induced vasoconstriction [PDF]
, 2003 The linkage of vascular genes to specific functions will lead to a better understanding of cardiovascular pathophysiology. We developed an experimental model that enables the introduction of one or multiple gene(s) into vascular smooth muscle cells ...
Pohl, U., Bolz, S. S.
core +1 more source
Rac and Rho GTPases in cancer cell motility control
Cell Communication and Signaling, 2010 Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation.
Parri Matteo, Chiarugi Paola
doaj +1 more source
A family of ras-like GTP-binding proteins expressed in electromotor neurons.
Journal of Biological Chemistry, 1991 The cDNAs encoding seven low molecular weight (LMW) GTP-binding proteins were isolated from an electrode lobe library of the marine ray Discopyge ommata. Four were assigned as the ray homologues of previously identified LMW GTP-binding proteins rab1, ral,
Johnny K. Ngsee +2 more
semanticscholar +1 more source
Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone
eFood, Volume 7, Issue 4, August 2026.Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu +4 more
wiley +1 more source
New Angle of View on the Role of Rho/Rho Kinase Pathway in Human Diseases
Iranian Journal of Allergy, Asthma and Immunology, 2014 Rho-kinase is an effector molecule of RhoA, a monomeric GTP-binding protein, and causes Ca2+ sensitization through inactivation of myosin phosphatase.
Wei Luo +4 more
doaj
Frontiers in Oncology, 2020 Although we currently have a good understanding of the role C-X-C chemokine receptor type 4 (CXCR4) plays in T cell acute lymphoblastic leukemia (T-ALL), the mechanism of CXCR4-mediated T-ALL migration remains elusive.
Jixian Luo +3 more
doaj +1 more source
Metabolic Regulation of Macrophages in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang +6 more
wiley +1 more source
Uptake of Clostridium botulinum C3 Exoenzyme into Intact HT22 and J774A.1 Cells
Toxins, 2015 The Clostridium botulinum C3 exoenzyme selectively ADP-ribosylates low molecular weight GTP-binding proteins RhoA, B and C. This covalent modification inhibits Rho signaling activity, resulting in distinct actin cytoskeleton changes.
Astrid Rohrbeck +3 more
doaj +1 more source