Results 61 to 70 of about 251,198 (269)
TRP Channels Regulation of Rho GTPases in Brain Context and Diseases
Frontiers in Cell and Developmental Biology, 2020 Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood ...
Boris Lavanderos +12 more
doaj +1 more source
Advanced Science, EarlyView.This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao +5 more
wiley +1 more source
Die Rolle von Rho-GTPasen bei der Migration von Stamm- und Progenitorzellen [PDF]
, 2006 Stem cells capable of self-renewal and differentiation into multiple tissues are important in medicine to reconstitute the hematopoietic system after myelo-ablative chemo- or radiotherapy.
Jaganthan, Bithiah Grace
core
GTPase-activating protein DLC1 spatio-temporally regulates Rho signaling
eLifeEmerging evidence suggests that Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) bind to the cytoskeleton or focal adhesions (FAs), controlling spatio-temporal Rho GTPase activity through feedback mechanisms.
Lucien Hinderling +6 more
doaj +1 more source
Rho family GTPases: Key players in neuronal development, neuronal survival, and neurodegeneration
Frontiers in Cellular Neuroscience, 2014 The Rho family of GTPases belongs to the Ras superfamily of low molecular weight (~21 kDa) guanine nucleotide binding proteins. The most extensively studied members are RhoA, Rac1, and Cdc42.
Trisha eStankiewicz +4 more
doaj +1 more source
Action potential-coupled Rho GTPase signaling drives presynaptic plasticity
eLife, 2021 In contrast to their postsynaptic counterparts, the contributions of activity-dependent cytoskeletal signaling to presynaptic plasticity remain controversial and poorly understood.
Shataakshi Dube O'Neil +6 more
doaj +1 more source
Structural Dynamics of Rho GTPases
Journal of Molecular BiologyRho family GTPases are a part of the Ras superfamily and are signaling hubs for many cellular processes. While the detailed understanding of Ras structure and function has led to tremendous progress in oncogenic Ras-targeted drug discovery, studies of the related Rho GTPases are still catching up as the recurrent cancer-related Rho GTPase mutations ...
Lin, Yuan, Zheng, Yi
openaire +2 more sources
Advanced Science, EarlyView.Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong +8 more
wiley +1 more source
Rho-GTPases subfamily: cellular defectors orchestrating viral infection
Cellular & Molecular Biology LettersRas homolog gene family-guanosine triphosphatases (Rho-GTPases), key molecular switches regulating cytoskeletal dynamics and cellular signaling, play a pivotal role in viral infections by modulating critical processes such as viral entry, replication ...
Beibei Zhang +5 more
doaj +1 more source
EBioMedicine, 2016 Despite ongoing research and recent progress, the prognosis for patients with advanced gastric cancer remains poor. Wnt/β-catenin and Rho-GTPase signaling pathways are known to play essential roles in malignant transformation and progression of various ...
Jung Hwan Yoon +6 more
doaj +1 more source