Results 41 to 50 of about 251,198 (269)
Signalling and function of the small Rho GTPase RhoJ in endothelial cells [PDF]
, 2011 RhoJ is an endothelial expressed Rho GTPase, and its knock-down impairs endothelial cell (EC) migration and tubulogenesis, increases stress fibre (SF) and focal adhesion (FA) numbers.
Leszczynska, Katarzyna
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A Rho-actin signaling pathway shapes cell wall boundaries in Arabidopsis xylem vessels
Nature Communications, 2019 Cell wall pits allow movement of water between xylem vessels and are formed via Rho-GTPase mediated signaling that leads to local microtubule disassembly. Here, Sugiyama et al.
Yuki Sugiyama +6 more
doaj +1 more source
Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases
Cells, 2019 As membrane-associated master regulators of cytoskeletal remodeling, Rho GTPases coordinate a wide range of biological processes such as cell adhesion, motility, and polarity.
Monilola A. Olayioye +2 more
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MICAL1 activation by PAK1 mediates actin filament disassembly
Cell Reports, 2022 Summary: The MICAL1 monooxygenase is an important regulator of filamentous actin (F-actin) structures. Although MICAL1 has been shown to be regulated via protein-protein interactions at the autoinhibitory carboxyl terminus, a link between actin ...
David J. McGarry +7 more
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Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]
, 2013 Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Liliana Schäfer +42 more
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Overexpression of RhoV Promotes the Progression and EGFR-TKI Resistance of Lung Adenocarcinoma
Frontiers in Oncology, 2021 BackgroundThe Rho GTPase family with ~20 member genes play central roles in a wide variety of cellular processes and tumor cell migration and metastasis.
Hongjin Chen +12 more
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Rho GTPases in Skeletal Muscle Development and Homeostasis
Cells, 2021 Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range
Sonia Rodríguez-Fdez, Xosé R. Bustelo
doaj +1 more source
Rho GTPases in erythroid maturation [PDF]
Current Opinion in Hematology, 2014 This review summarizes our current understanding of the roles of Rho GTPases in early erythropoiesis, downstream of cytokine signaling, and in terminal erythroblast maturation and enucleation, as master regulators of the cytoskeleton and cytokinesis.Similarities of structural and signaling requirements of erythroblast enucleation with the cytokinesis ...
Theodosia A, Kalfa, Yi, Zheng
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Analysis of Rho GTPase signalling pathways regulating epithelial morphogenesis [PDF]
, 2010 Rho GTPases are molecular switches controlling many aspects of cell behaviour, including cell cycle progression, cell division, migration and morphology. The activity of Rho proteins is regulated by conformational changes induced by binding of guanine
Wallace, S.
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