Results 1 to 10 of about 1,377 (129)

Molecules and mechanisms that regulate multipolar migration in the intermediate zone

Frontiers in Cellular Neuroscience, 2014
Most neurons migrate with an elongated, bipolar morphology, extending a long leading process that explores the environment. However, when immature projection neurons enter the intermediate zone of the neocortex they become multipolar.
Jonathan A Cooper
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The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2

Cell Communication and Signaling, 2011
Background Host cell invasion by the foodborne pathogen Campylobacter jejuni is considered as one of the primary reasons of gut tissue damage, however, mechanisms and key factors involved in this process are widely unclear. It was reported that small Rho
Krause-Gruszczynska Malgorzata, Boehm Manja, Rohde Manfred, Tegtmeyer Nicole, Takahashi Seiichiro, Buday Laszlo, Oyarzabal Omar A, Backert Steffen   +7 more
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Topological and functional properties of the small GTPases protein interaction network. [PDF]

PLoS ONE, 2012
Small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) regulate key cellular processes such as signal transduction, cell proliferation, cell motility, and vesicle transport.
Anna Delprato
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Data from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<div><p>Rac and Cdc42, are homologous GTPases that regulate cell migration, invasion, and cell-cycle progression; thus, representing key targets for metastasis therapy. We previously reported on the efficacy of MBQ-167, which blocks both Rac1 and Cdc42 in breast cancer cells and mouse models of metastasis.
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
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Detecting Protein-Protein Interactions Using Renilla Luciferase Fusion Proteins

BioTechniques, 2002
We have developed a novel system designated the luciferase assay for protein detection (LAPD) to study protein-protein interactions. This method involves two protein fusions, a soluble reporter fusion and a fusion for immobilizing the target protein. The
Peter D. Burbelo, Adam E. Kisailus, Jeremy W. Peck   +2 more
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The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

Cell, 1995
c-Jun amino-terminal kinases (JNKs) and mitogen-activated protein kinases (MAPKs) are closely related; however, they are independently regulated by a variety of environmental stimuli. Although molecules linking growth factor receptors to MAPKs have been recently identified, little is known about pathways controlling JNK activation.
Coso OA, Chiariello M, Yu, JC, Teramoto H, Crespo P, Xu N, Miki T, Gutkind JS   +8 more
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Suppl. Fig. S4 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplementary Figure S4 shows the safety of MBQ compounds in mice.</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
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Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion. [PDF]

Journal of Clinical Investigation, 1996
Several GTP-binding proteins (G-proteins) undergo post-translational modifications (isoprenylation and carboxyl methylation) in pancreatic beta cells. Herein, two of these were identified as CDC42 and rap 1, using Western blotting and immunoprecipitation.
A, Kowluru, S E, Seavey, G, Li, R L, Sorenson, A J, Weinhaus, R, Nesher, M E, Rabaglia, J, Vadakekalam, S A, Metz   +8 more
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Suppl. Fig. S6 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplementary Figure S6 shows the inhibition of Rac1B, Rac1, and Rac1 P29S by MBQ-167</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
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Host Defense Peptide LL-37-Mediated Chemoattractant Properties, but Not Anti-Inflammatory Cytokine IL-1RA Production, Is Selectively Controlled by Cdc42 Rho GTPase via G Protein-Coupled Receptors and JNK Mitogen-Activated Protein Kinase

Frontiers in Immunology, 2018
The human host defense peptide LL-37 promotes immune activation such as induction of chemokine production and recruitment of leukocytes. Conversely, LL-37 also mediates anti-inflammatory responses such as production of anti-inflammatory cytokines, e.g ...
Mahadevappa Hemshekhar, Ka-Yee Grace Choi, Ka-Yee Grace Choi, Neeloffer Mookherjee, Neeloffer Mookherjee   +4 more
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