Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI [PDF]
Cell, 2000 The RhoGDI proteins serve as key multifunctional regulators of Rho family GTP-binding proteins. The 2.6 A X-ray crystallographic structure of the Cdc42/RhoGDI complex reveals two important sites of interaction between GDI and Cdc42. First, the amino-terminal regulatory arm of the GDI binds to the switch I and II domains of Cdc42 leading to the ...
Richard Cerione +2 more
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The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42 [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1998 The small GTP-binding protein Cdc42 is thought to induce filopodium formation by regulating actin polymerization at the cell cortex. Although several Cdc42-binding proteins have been identified and some of them have been implicated in filopodium formation, the precise role of Cdc42 in modulating actin polymerization has not been ...
Marc Kirschner, Kirschner Marc W
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Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1990 We have isolated cDNA clones from a human placental library that code for a low molecular weight GTP-binding protein originally designated Gp (also called G25K). This identification is based on comparisons with the available peptide sequences for the purified human Gp protein and the use of two highly specific anti-peptide antibodies.
Matthew Hart +2 more
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Atypical Protein Kinases Cλ and -ζ Associate with the GTP-Binding Protein Cdc42 and Mediate Stress Fiber Loss [PDF]
Molecular and Cellular Biology, 2000 Both the Rho family of low-molecular-weight GTP-binding proteins and protein kinases C (PKCs) mediate responses to a variety of extracellular and intracellular signals. They share many downstream targets, including remodeling of the actin cytoskeleton, activation of p70(S6) kinase and c-jun N-terminal kinase (JNK), and regulation of transcription and ...
Margaret M Chou, C L Carpenter
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CDC42 (cell division cycle 42 (GTP binding protein, 25kDa)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CDC42 (cell division cycle 42 (GTP binding protein, 25kDa)), with data on DNA, on the protein encoded, and where the gene is implicated.
Fatima Valdes-Mora
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Causal cross-trait mapping at single-cell resolution identifies shared immunogenetic drivers of migraine and Meniere’s disease [PDF]
The Journal of Headache and PainBackground Migraine and Meniere’s disease (MD) show high clinical comorbidity, shared symptoms such as vertigo and overlapping mechanisms like neurogenic inflammation suggest common pathophysiology. However, the core immunogenetic drivers underlying this
Xiao Hu +7 more
doaj +2 more sources
Rho/ROCK Signaling Pathway in Kidney Diseases: Mechanisms and Therapeutic Perspectives [PDF]
BiomedicinesRho GTPases are a group of guanosine triphosphate (GTP)-binding proteins with a relative molecular weight of about 20–30 kD, and 22 different Rho GTPases have been identified in mammalian cells, among which RhoA, Rac1 and Cdc42 are the most well-studied.
Wei Xiong +4 more
doaj +2 more sources
Matrix metalloproteinase-9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells. [PDF]
FEBS Open BioMatrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Strauel C +8 more
europepmc +2 more sources
Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway [PDF]
Journal of Biological Chemistry, 1996 J Silvio Gutkind +2 more
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Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42
Cancer Research Communications, 2022 Rac and Cdc42, are homologous GTPases that regulate cell migration, invasion, and cell-cycle progression; thus, representing key targets for metastasis therapy. We previously reported on the efficacy of MBQ-167, which blocks both Rac1 and Cdc42 in breast cancer cells and mouse models of metastasis. To identify compounds with increased activity, a panel
Julia I. Medina +9 more
openaire +2 more sources