Results 11 to 20 of about 4,215,470 (170)
Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. [PDF]
The EMBO Journal, 1996 STE20 encodes a protein kinase related to mammalian p65Pak which functions in several signal transduction pathways in yeast, including those involved in pseudohyphal and invasive growth, as well as mating. In addition, Ste20 plays an essential role in cells lacking Cla4, a kinase with significant homology to Ste20.
M, Peter +4 more
core +4 more sources
Frontiers in Microbiology, 2021 Hepatitis E Virus (HEV) causes viral hepatitis in humans worldwide, while a subset of HEV species, avian HEV, causes hepatitis-splenomegaly syndrome in chickens.
Mengnan Fan +10 more
doaj +1 more source
Scientific Reports, 2022 The small GTPase Cdc42 is an integral component of the cytoskeleton, and its dysregulation leads to pathophysiological conditions, such as cancer. Binding of Cdc42 to the scaffold protein IQGAP1 stabilizes Cdc42 in its active form.
Samar Sayedyahossein +14 more
doaj +1 more source
Frontiers in Genetics, 2022 Small GTPases are the key to actin cytoskeleton signaling, which opens the lock of effector proteins to forward the signal downstream in several cellular pathways. Actin cytoskeleton assembly is associated with cell polarity, adhesion, movement and other
Preeti Umarao +2 more
doaj +1 more source
Cdc42 functions as a regulatory node for tumour‐derived microvesicle biogenesis
Journal of Extracellular Vesicles, 2021 Tumour‐derived microvesicles (MVs) serve as critical mediators of cell‐to‐cell communication in the tumour microenvironment. So far, the underlying mechanisms of MV biogenesis, especially how key tumorigenesis signals such as abnormal EGF signalling ...
Jing Wang +9 more
doaj +1 more source
Rho GTPases and regulation of cell migration and polarization in human corneal epithelial cells. [PDF]
PLoS ONE, 2013 PURPOSE:Epithelial cell migration is required for regeneration of tissues and can be defective in a number of ocular surface diseases. This study aimed to determine the expression pattern of Rho family small G-proteins in human corneal epithelial cells ...
Aihua Hou +5 more
doaj +1 more source
The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death [PDF]
Proceedings of the National Academy of Sciences, 1998 An increase in the level of the c-Jun transcription factor and of its phosphorylation has previously been shown to be essential for nerve growth factor (NGF) withdrawal-induced apoptosis of rat sympathetic neurons (SCG). The Rho-like GTPases Cdc42 and Rac1 are involved in the regulation of a number of cellular processes, including ...
C E, Bazenet, M A, Mota, L L, Rubin
openaire +2 more sources
MECHANISMS FOR THE STRUCTURAL ACTIVATION OF THE SMALL G PROTEIN CDC42 AND ITS CONSTITUTIVELY ACTIVATED MUTANT, CDC42 (Q61L) [PDF]
, 2008 The x-ray crystal structures for the GTP-bound forms of the small G protein Cdc42 and its constitutively activated isoform, Cdc42 (Q61L), were previously unkown.
Phillips, Matthew
core +6 more sources
Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg Extracts [PDF]
The Journal of Cell Biology, 1998 Both phosphoinositides and small GTP-binding proteins of the Rho family have been postulated to regulate actin assembly in cells. We have reconstituted actin assembly in response to these signals in Xenopus extracts and examined the relationship of these pathways. We have found that GTPγS stimulates actin assembly in the presence of endogenous membrane
L, Ma +3 more
openaire +2 more sources
Stem Cell Research & Therapy, 2023 Background CDC42 is a member of Rho GTPase family, acting as a molecular switch to regulate cytoskeleton organization and junction maturation of epithelium in organ development.
Tao Zhou +6 more
doaj +1 more source