CDC42 (cell division cycle 42 (GTP binding protein, 25kDa)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CDC42 (cell division cycle 42 (GTP binding protein, 25kDa)), with data on DNA, on the protein encoded, and where the gene is implicated.
Valdés-Mora, F +2 more
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Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI [PDF]
Cell, 2000 The RhoGDI proteins serve as key multifunctional regulators of Rho family GTP-binding proteins. The 2.6 A X-ray crystallographic structure of the Cdc42/RhoGDI complex reveals two important sites of interaction between GDI and Cdc42. First, the amino-terminal regulatory arm of the GDI binds to the switch I and II domains of Cdc42 leading to the ...
Nicolas Nassar, Richard A Cerione
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Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. [PDF]
EMBO Journal, 1996 STE20 encodes a protein kinase related to mammalian p65Pak which functions in several signal transduction pathways in yeast, including those involved in pseudohyphal and invasive growth, as well as mating. In addition, Ste20 plays an essential role in cells lacking Cla4, a kinase with significant homology to Ste20.
I Herskowitz
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The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42 [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1998 The small GTP-binding protein Cdc42 is thought to induce filopodium formation by regulating actin polymerization at the cell cortex. Although several Cdc42-binding proteins have been identified and some of them have been implicated in filopodium formation, the precise role of Cdc42 in modulating actin polymerization has not been defined ...
Rajat Rohatgi +2 more
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Atypical Protein Kinases Cλ and -ζ Associate with the GTP-Binding Protein Cdc42 and Mediate Stress Fiber Loss [PDF]
Molecular and Cellular Biology, 2000 Both the Rho family of low-molecular-weight GTP-binding proteins and protein kinases C (PKCs) mediate responses to a variety of extracellular and intracellular signals. They share many downstream targets, including remodeling of the actin cytoskeleton, activation of p70(S6) kinase and c-jun N-terminal kinase (JNK), and regulation of transcription and ...
Margaret M Chou, Christopher L Carpenter
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Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1990 We have isolated cDNA clones from a human placental library that code for a low molecular weight GTP-binding protein originally designated Gp (also called G25K). This identification is based on comparisons with the available peptide sequences for the purified human Gp protein and the use of two highly specific anti-peptide antibodies.
John G Koland +2 more
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Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway [PDF]
Journal of Biological Chemistry, 1996 Hidemi Teramoto +2 more
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Frontiers in Microbiology, 2021 Hepatitis E Virus (HEV) causes viral hepatitis in humans worldwide, while a subset of HEV species, avian HEV, causes hepatitis-splenomegaly syndrome in chickens.
Mengnan Fan +10 more
doaj +1 more source
Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42
Cancer Research Communications, 2022 Rac and Cdc42, are homologous GTPases that regulate cell migration, invasion, and cell-cycle progression; thus, representing key targets for metastasis therapy. We previously reported on the efficacy of MBQ-167, which blocks both Rac1 and Cdc42 in breast cancer cells and mouse models of metastasis. To identify compounds with increased activity, a panel
Julia I. Medina +9 more
openaire +2 more sources
Scientific Reports, 2022 The small GTPase Cdc42 is an integral component of the cytoskeleton, and its dysregulation leads to pathophysiological conditions, such as cancer. Binding of Cdc42 to the scaffold protein IQGAP1 stabilizes Cdc42 in its active form.
Samar Sayedyahossein +14 more
doaj +1 more source