Results 41 to 50 of about 4,215,470 (170)

Supplementary Methods SM1 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplementary methods</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source

Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion. [PDF]

Journal of Clinical Investigation, 1996
Several GTP-binding proteins (G-proteins) undergo post-translational modifications (isoprenylation and carboxyl methylation) in pancreatic beta cells. Herein, two of these were identified as CDC42 and rap 1, using Western blotting and immunoprecipitation.
A, Kowluru, S E, Seavey, G, Li, R L, Sorenson, A J, Weinhaus, R, Nesher, M E, Rabaglia, J, Vadakekalam, S A, Metz   +8 more
openaire   +2 more sources

Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes [PDF]

, 2006
Peer ...
Pokhilko, Alexandra V, Goryachev, Andrew B, Alexandra V Pokhilko, Goryachev Andrew B, Andrew B Goryachev, Pokhilko Alexandra V   +5 more
core   +2 more sources

Suppl. Fig. S7 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplementary Figure S7 shows the effect of MBQ-167 on Rac1(G15A) association with Tiam-1 and p-REX-1.</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source

Host Defense Peptide LL-37-Mediated Chemoattractant Properties, but Not Anti-Inflammatory Cytokine IL-1RA Production, Is Selectively Controlled by Cdc42 Rho GTPase via G Protein-Coupled Receptors and JNK Mitogen-Activated Protein Kinase

Frontiers in Immunology, 2018
The human host defense peptide LL-37 promotes immune activation such as induction of chemokine production and recruitment of leukocytes. Conversely, LL-37 also mediates anti-inflammatory responses such as production of anti-inflammatory cytokines, e.g ...
Mahadevappa Hemshekhar, Ka-Yee Grace Choi, Ka-Yee Grace Choi, Neeloffer Mookherjee, Neeloffer Mookherjee   +4 more
doaj   +1 more source

Transition to Quorum Sensing in an Agrobacterium Population: A Stochastic Model. [PDF]

, 2005
Understanding of the intracellular molecular machinery that is responsible for the complex collective behavior of multicellular populations is an exigent problem of modern biology.
Zhang, Lian-Hui, Travis Lee (274971), Keng Boon Wee (43442), Lee Travis, Da-Jun Toh (274970), Andrew B Goryachev, Wee Keng Boon, Lian-Hui Zhang, Lian-Hui Zhang (119133), Keng Boon Wee, Zhang, Hai-Bao, Toh, Da-Jun, Wee, Keng Boon, Goryachev, Andrew B, Hai-Bao Zhang, Andrew B Goryachev (274969), Da-Jun Toh, Lee, Travis, Goryachev Andrew B, Toh Da-Jun, Hai-Bao Zhang (274972), Zhang Hai-Bao, Travis Lee, Zhang Lian-Hui   +23 more
core   +2 more sources

Expression of FGD4 positively correlates with the aggressive phenotype of prostate cancer

BMC Cancer, 2018
Background FGD4 (Frabin) is an F-actin binding protein with GTP/GDP exchange activity specific for CDC42. It is involved in reorganization of the actin cytoskeleton, which requires both actin binding and CDC42 activating function of FGD4.
Alexia Bossan, Richard Ottman, Thomas Andl, Md Faqrul Hasan, Nupam Mahajan, Domenico Coppola, Ratna Chakrabarti   +6 more
doaj   +1 more source

Suppl. Fig. S3 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Suppl. Fig. S3 shows the effect of MBQ-167 and derivatives on lung cancer cells.</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source

Suppl. Fig. S2 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplemental Figure S2 shows the Effect of MBQ compounds on cell migration</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source

Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells [PDF]

, 1992
Specific antibodies against rap1A and rap1B small GTP-binding proteins were generated by immunization of rabbits with peptides derived from the C-terminus of the processed proteins.
Schwaner, I., Frank, R., Gausepohl, H., Seifert, Roland, Schultz, Günter, Klinz, F. J.   +5 more
core   +1 more source