Results 61 to 70 of about 1,377 (129)

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 698-710, June 2026.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin

, 2001
Cdc42Hs is involved in cytoskeletal reorganization and is required for neurite outgrowth in N1E-115 cells. To investigate the molecular mechanism by which Cdc42Hs regulates these processes, a search for novel Cdc42Hs protein partners was undertaken by ...
Sheila Govind, Louis Lim, Ahmed, S., Clinton Monfries, Kozma, R., Robert Kozma, Lim, L., Govind, S., Monfries, C., Sohail Ahmed   +9 more
core   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Enabling systemic identification and functionality profiling for Cdc42 homeostatic modulators

Communications Chemistry
Maintaining body homeostasis is the ultimate key to health. There are rich resources of bioactive materials for the functionality of homeostatic modulators (HMs) from both natural and synthetic chemical repertories1–3.
Satyaveni Malasala, Fereshteh Azimian, Yan-Hua Chen, Jeffery L. Twiss, Christi Boykin, Shayan Nik Akhtar, Qun Lu   +6 more
doaj   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Use of tandem‐affinity chromatography to incorporate nucleotide loading of small GTPases during their purification

Protein Science, Volume 35, Issue 6, June 2026.
Abstract A bottleneck for structure–function studies of closely related proteins is purification. Here, we built upon new affinity protein purification technology to develop a uniform and rapid tandem‐affinity purification protocol to generate significant quantities of pure GTPase proteins for use in structure–function studies. Our method relies on new
Rofiat Oladimeji, Chigozie Odo, Ethan Lewis, Gracie Reid, Christian W. Johnson   +4 more
wiley   +1 more source

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source

Ect2/Pbl Acts via Rho and Polarity Proteins to Direct the Assembly of an Isotropic Actomyosin Cortex upon Mitotic Entry.

, 2015
Entry into mitosis is accompanied by profound changes in cortical actomyosin organization. Here, we delineate a pathway downstream of the RhoGEF Pbl/Ect2 that directs this process in a model epithelium.
Rosa, André, Pichaud, Franck, Vlassaks, E, Baum, B, Pichaud, F, Rosa, A, Vlassaks, Evi, Baum, Buzz   +7 more
core   +1 more source

Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with filamin and cortexillin I. [PDF]

, 2010
Filamin and Cortexillin are F-actin crosslinking proteins in Dictyostelium discoideum allowing actin filaments to form three-dimensional networks. GAPA, an IQGAP related protein, is required for cytokinesis and localizes to the cleavage furrow during ...
Bhagyashri Burgute, Müller Rolf, Müller, Rolf, Schleicher Michael, Daniela Rieger, Rieger, Daniela, Angelika A Noegel, Faix Jan, Noegel, Angelika A., Angelika A. Noegel, Rivero Francisco, Rolf Müller, Faix, Jan, Schleicher, Michael, Burgute Bhagyashri, Francisco Rivero, Subhanjan Mondal, Mondal, Subhanjan, Rieger Daniela, Rivero, Francisco, Michael Schleicher, Burgute, Bhagyashri, Mondal Subhanjan, Noegel Angelika A., Jan Faix   +24 more
core   +1 more source

CDC42-IQGAP Interactions Scrutinized: New Insights into the Binding Properties of the GAP-Related Domain

, 2022
The IQ motif-containing GTPase-activating protein (IQGAP) family composes of three highly-related and evolutionarily conserved paralogs (IQGAP1, IQGAP2 and IQGAP3), which fine tune as scaffolding proteins numerous fundamental cellular processes.
Pudewell, Silke, Kazemein Jasemi, Neda S, Neda S. Kazemein Jasemi, Lothar Gremer, Krumbach, Oliver H F, Niloufar Mosaddeghzadeh, Willbold, Dieter, Farhad Bazgir, Dvorsky, Radovan, Kazemein Jasemi, Neda S., Bazgir, Farhad, Ahmadian, Mohammad R, Ahmadian, Mohammad R., Mohammad R. Ahmadian, Mosaddeghzadeh, Niloufar, Radovan Dvorsky, Oliver H. F. Krumbach, Krumbach, Oliver H. F., Dieter Willbold, Silke Pudewell, Gremer, Lothar   +20 more
core   +1 more source