Results 81 to 90 of about 1,377 (129)

Phosphatidylserine polarization is required for proper Cdc42 localization and for development of cell polarity.

, 2010
We used genetically-encoded fluorescent probes to visualize the distribution of phosphatidylserine (PS) in live S. cerevisiae. The majority of the PS was found to reside in the cytosolic leaflet of the plasma membrane.
Gregory Fairn, Sergio Grinstein
core  

Cdc42 induces EGF receptor protein accumulation and promotes EGF receptor nuclear transport and cellular transformation

, 2014
Cdc42 is a Ras-related small GTP-binding protein. A previous study has shown that Cdc42 binding to the γ subunit of the coatomer protein complex (γCOP) is essential for Cdc42-regulated cellular transformation, but the molecular mechanism involved is not ...
Cheng, Jin-Quan, Wang, Jian-Bin, Li, Yong, Han, Tian-Yu, Xiao-Yu Wang, Jin-Quan Cheng, Jian-Bin Wang, Han, Xiao-Jian, Tian-Yu Han, Gan, Ming-Xi, Wei-Hua Zhan, Xiao-Jian Han, Ming-Xi Gan, Zhan, Wei-Hua, Wang, Xiao-Yu, Yong Li   +15 more
core   +1 more source

Pathological Roles of Astrocytes in Traumatic Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu, Yuxiao Ma, Baofeng Wang, Yongtao Zheng, Jie Ren, Qingfang Sun, Liuguan Bian, Yuhao Sun   +7 more
wiley   +1 more source

Cdc42 promotes transendothelial migration of cancer cells through β1 integrin.

, 2012
Cancer cells interact with endothelial cells during the process of metastatic spreading. Here, we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify Cdc42 as a critical regulator of cancer cell-endothelial cell ...
Valderrama, F, Riou, P, Muschel, Ruth, Susan Cox, Garg, Ritu, Vega, FM, Im, Jae Hong, Im, JH, Valderrama, Ferran, Ritu Garg, Muschel, Ruth J, Ridley, Anne J, Garg, R, Cox, Susan, Barbara Borda d’Agua, Cox, S, Vega, Francisco M., d'Agua, Barbara Borda, Reymond, N, Nicolas Reymond, Philippe Riou, Borda d'Agua, Barbara, Ferran Valderrama, Reymond, Nicolas, Jae Hong Im, Riou, Philippe, Muschel, Ruth J., Borda d'Agua, B, Ridley, AJ, Francisco M. Vega, Muschel, RJ, Anne J. Ridley, Ridley, Anne J., Vega, Francisco M, Ruth J. Muschel   +34 more
core   +1 more source

RhoGDI Is Required for Cdc42-Mediated Cellular Transformation

, 2003
Background: Cdc42, a Rho-related small GTP binding protein, plays pivotal roles in actin cytoskeletal organization, Golgi vesicular trafficking, receptor endocytosis, and cell cycle progression.
Fuji, Reina N., Cerione, Richard A., Yang, Wannian, Lin, Qiong   +3 more
core   +1 more source

Analysis of Rho GTPase signalling pathways regulating epithelial morphogenesis

, 2010
Rho GTPases are molecular switches controlling many aspects of cell behaviour, including cell cycle progression, cell division, migration and morphology. The activity of Rho proteins is regulated by conformational changes induced by binding of guanine
Wallace, S.
core  

A Link between Cdc42 and Syntaxin Is Involved in Mastoparan-Stimulated Insulin Release^†

, 2016
Mastoparan, a hormone receptor-mimetic peptide isolated from wasp venom, stimulates insulin release from pancreatic β-cells in a Ca2+-independent but GTP-dependent manner.
Geoffrey W. G. Sharp (2946984), Mitsuhiko Noda (176917), Richard A. Cerione (464912), Samira Daniel (2946987)   +3 more
core   +1 more source

A method to measure the interaction of Rac/Cdc42 with their binding partners using fluorescence resonance energy transfer between mutants of green fluorescent protein

, 2001
Enhanced blue fluorescent protein (EBFP) and enhanced green fluorescent protein (EGFP) mutants of GFP in close proximity to one another can act as a fluorescence resonance energy transfer (FRET) pair.
Cunningham, Debbie, Lowe, Peter N, Chalk, P A   +2 more
core   +1 more source

Molecular and cellular basis of the internalization of "Bartonella henselae" by human endothelial cells [PDF]

, 2007
The facultative intracellular bacterium Bartonella henselae enters human endothelial cells either passively by conventional phagocytosis or actively by a pathogen-triggered process known as invasome-mediated internalization.
Rhomberg, Thomas Alexander
core   +1 more source

Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction

, 2018
The formation of a local zone of Cdc42 GTPase activity, which governs cell polarization in many cell types, requires not only local activation but also switch-off mechanisms.
Gallo Castro, Daniela, Martin, Sophie, Gallo Castro, D., Daniela Gallo Castro, Sophie G. Martin, Martin, S.G., Sophie G Martin   +6 more
core   +1 more source