Results 101 to 110 of about 1,377 (129)

Editorial: Rho family GTPases and their effectors in neuronal survival and neurodegeneration

Frontiers in Cellular Neuroscience, 2023
Daniel A. Linseman, Qun Lu
doaj   +1 more source

Characterisation of the nucleotide exchange factor ITSN1L: evidence for a kinetic discrimination of GEF-stimulated nucleotide release from Cdc42

, 2009
Cdc42, a member of the Ras superfamily of small guanine nucleotide binding proteins, plays an important role in regulating the actin cytoskeleton, intracellular trafficking, and cell polarity.
Groemping, Y., Kintscher, C.
core   +1 more source

A Switch I Mutant of Cdc42 Exhibits Less Conformational Freedom

, 2016
Cdc42 is a Ras-related small G-protein and functions as a molecular switch in signal transduction pathways linked with cell growth and differentiation. It is controlled by cycling between GTP-bound (active) and GDP-bound (inactive) forms.
Hana Krizova (2181682), Omar Salem (2181684), Reena Chandrashekar (2181680), Paul D. Adams (242976), Robert McFeeters (2181678)   +4 more
core   +1 more source

Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis

, 2007
During animal cell chemotaxis, signalling at the plasma membrane induces actin polymerisation to drive forward cell movement. Since the cellular pool of actin is limited, efficient protrusion formation also requires the coordinated disassembly of pre ...
Larsen, MR, Baum, B, Waterfield, MD, Jovceva, E, Timms, JF   +4 more
core  

Orf protein modulates phage and bacterial pathways of genetic recombination [PDF]

, 2008
The emergence of novel pathogenic organisms due to the acquisition of virulencedeterminants from bacteriophages has generated significant interest in the pathways responsible for genomic rearrangements.
Bowers, Laura Yvonne
core  

RabGEF1 differentially regulates activation of Ras, Rac1, and Cdc42 in NGF-differentiated PC12 cells.

, 2015
A) NGF-induced Ras activation was reduced in RabGEF1-AS transfectants. CMV and AS transfectants were stimulated by NGF (50 ng/ml) for the indicated times.
Janet Kalesnikoff (828869), See-Ying Tam (828866), Jennifer N. Lilla (828867), Ching-Cheng Chen (828868), Mindy Tsai (395467)   +4 more
core   +1 more source

Characterizing the role of p21-Activated Kinase 3 (PAK3) in AP-1-induced transformation

, 2014
Includes bibliographical references.Previous studies identified p21-Activated Kinase 3 (PAK3), a serine/threonine kinase, as a potential AP-1 target gene.
Holderness-Parker, Nina Alison Victoria
core  

The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42

, 2010
Background: Guanidine exchange factor (GEF)-catalysed activation of Rho proteins such as Cdc42 has been shown to have a crucial role in cellular transformation, malignant progression and invasion.
K Borthwick, I N Hampson, L Hampson, Donne, A. J., A J Donne, Borthwick, K., He, X., Hampson, L., Oliver, A. W., Hampson, I. N., A W Oliver, X He   +11 more
core   +1 more source

Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.

, 2016
Transducer of Cdc42-dependent actin assembly protein 1 (TOCA1) is an effector of the Rho family small G protein Cdc42. It contains a membrane-deforming F-BAR domain as well as a Src homology 3 (SH3) domain and a G protein-binding homology region 1 (HR1 ...

core   +1 more source

Transglutaminase in the life and death of the pancreatic β-cell

, 2010
Tissue transglutaminase (TG2) is a ubiquitous enzyme that catalyses both the Ca2+-dependent formation of protein cross-links via intermolecular isopeptide bonds, and the Ca2+-independent hydrolysis of GTP.
Dookie, S
core