Results 71 to 80 of about 1,377 (129)

Causal cross-trait mapping at single-cell resolution identifies shared immunogenetic drivers of migraine and Meniere’s disease

The Journal of Headache and Pain
Background Migraine and Meniere’s disease (MD) show high clinical comorbidity, shared symptoms such as vertigo and overlapping mechanisms like neurogenic inflammation suggest common pathophysiology. However, the core immunogenetic drivers underlying this
Xiao Hu, Yang Wang, Si-Jie Yu, Chun-Ya Pan, Bing-Yu Liang, Shang-Shang Jiang, Shan-Wen Chen, Yan-Xun Han   +7 more
doaj   +1 more source

Septins in the Middle—Makers and Breakers of Membrane Contact Sites

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Septins are a family of GTP‐binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. Growing evidence places septins at membrane contact sites (MCS) — key hubs for intracellular communication that mediate exchange of ions, lipids, and ...
TrishaJean J. Holt, Elias T. Spiliotis
wiley   +1 more source

Effect of the Mutual Interaction of GPNMB and LPAR1 on Cellular Motility and Tumorigenicity in Mammary Epithelial Cells

Pathology International, Volume 76, Issue 6, June 2026.
GPNMB and LPAR1 form a positive feedback loop enhancing LPA signaling. LPA–LPAR1 activates RhoA–ROCK, driving actin reorganization and cell motility. GPNMB–LPAR1 signaling promotes tumorigenic potential. ABSTRACT Glycoprotein non‐metastatic melanoma protein B (GPNMB) is a poor prognostic factor, which is highly expressed in many types of malignant ...
Minori Kimura, Yukari Okita, Erina Iwabuchi, Xinzhu Hong, Yumu Ichikawa, Manar A. Elhinnawi, Hironobu Sasano, Mitsuyasu Kato   +7 more
wiley   +1 more source

MECHANISMS FOR THE STRUCTURAL ACTIVATION OF THE SMALL G PROTEIN CDC42 AND ITS CONSTITUTIVELY ACTIVATED MUTANT, CDC42 (Q61L) [PDF]

, 2008
The x-ray crystal structures for the GTP-bound forms of the small G protein Cdc42 and its constitutively activated isoform, Cdc42 (Q61L), were previously unkown.
Phillips, Matthew
core  

Rho/ROCK Signaling Pathway in Kidney Diseases: Mechanisms and Therapeutic Perspectives

Biomedicines
Rho GTPases are a group of guanosine triphosphate (GTP)-binding proteins with a relative molecular weight of about 20–30 kD, and 22 different Rho GTPases have been identified in mammalian cells, among which RhoA, Rac1 and Cdc42 are the most well-studied.
Wei Xiong, Daojia Miao, Zongchen Hou, Xiaoping Zhang, Zhiyong Xiong   +4 more
doaj   +1 more source

MicroRNA‐Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery

Brain and Behavior, Volume 16, Issue 5, May 2026.
Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah, Pareshkumar N. Patel, Omayma Salim Waleed, Jamuna K. V., Vandana Tripathi, L. Lakshmi, Rajashree Panigrahi, Manoj Kumar Mishra   +7 more
wiley   +1 more source

Polarization as a Process: The Potential of Process Ontology for Understanding Cellular Symmetry Breaking

BioEssays, Volume 48, Issue 4, April 2026.
Process ontology proposes that biological systems are best understood as composed of dynamic processes rather than static components. However, application to concrete research practice has remained challenging. We use cell polarity in budding yeast as a case study to examine the implications of applying process philosophy to cell biological research ...
Marieke M. Glazenburg, Liedewij Laan
wiley   +1 more source

alpha 2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells

, 2001
Neuronal differentiation involves Rac and Cdc42 GTPases. alpha -Chimaerin, a Rac/Cdc42 regulator, occurs as alpha 1- and alternatively spliced Src homology 2 (SH2) domain-containing alpha 2-isoforms. alpha 2-chimaerin mRNA was highly expressed in the rat
Christine Hall, Giovanna Ferrari, Nansi Cann, Teo, M., Clinton Monfries, Michael, G.J., Cann, N., Louis Lim, Ferrari, G., Jacobs, T., Mabel Teo, Hall, C., Tom Jacobs, Lim, L., Gregory J. Michael, Monfries, C.   +15 more
core   +1 more source

NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis

Cellular & Molecular Biology Letters
Background Members of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various physiological and pathological processes. However, none have been shown to regulate actin cap formation or
Li-Ya Shi, Yang Wang, Yan-Jie Yang, Qian Li, Zhi-Xia Yang, Li-Hua Sun, Fu-Qiang Luo, Yu-hao He, Shu-Ping Zhang, Ning Su, Jia-Qi Liu, Ye He, Yi-Chun Guan, Zhao-Lian Wei, Yun-Xia Cao, Dong Zhang   +15 more
doaj   +1 more source

Profiling Ten RHO GTPases in Myeloid Malignancies Reveals Distinct Expression Patterns and Prognostic Associations

Cancer Medicine, Volume 15, Issue 4, April 2026.
Expression of RHO GTPases in myeloid malignancies. Gene expression analysis of ten RHO GTPases revealed RHOBTB2, RND2, and RHOQ as differently expressed in patients with MDS and/or AML. RHOBTB2 was identified as a promising prognostic indicator. BM, bone marrow. MDS, myelodysplastic neoplasm. AML, acute myeloid leukemia.
Beatriz de Almeida Rodrigues, Luciana Bueno de Paiva, Maria Carolina Clares Ramalho, Amanda Ferreira Damasceno, Sara Teresinha Olalla Saad, Mariana Lazarini   +5 more
wiley   +1 more source