Results 31 to 40 of about 1,377 (129)

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. [PDF]

PLoS ONE, 2010
Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro.Here, we show that the rho guanine ...
Karina Haebig, Christian Johannes Gloeckner, Marta Garcia Miralles, Frank Gillardon, Claudia Schulte, Olaf Riess, Marius Ueffing, Saskia Biskup, Michael Bonin   +8 more
doaj   +1 more source

Vav Proteins in Development of the Brain: A Potential Relationship to the Pathogenesis of Congenital Zika Syndrome?

Viruses, 2022
Zika virus (ZIKV) infection during pregnancy can result in a significant impact on the brain and eye of the developing fetus, termed congenital zika syndrome (CZS).
Aidan J. Norbury, Lachlan A. Jolly, Luke P. Kris, Jillian M. Carr   +3 more
doaj   +1 more source

The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering [PDF]

, 2004
Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by the multidomain protein gephyrin, which in turn is translocated to the cell membrane by the GDP-GTP exchange factor collybistin.
Ward, H, Harvey, R.J., Alldred, Melissa J., Smart, T.G., Luscher, B, Duguid, Ian C, Lingenfelter, S E, Duguid, IC, Ward, H., Lingenfelter, Sue E., Alldred, M.J., Harvey, Robert J., Pearce, B R, Lundgren, J.D., Harvey, K, Owen, Michael John, Pearce, Brian R., Beatty, S.E., Smart, Trevor G., Owens, Max J., Keep, N H, Harvey, RJ, Lingenfelter, S.E., Harvey, Robert J, Keep, NH, Lundgren, J, Owen, MJ, Lund University., Ward, Hamish, Smart, T G, Pearce, B.R., Lüscher, Bernhard, Beatty, Sarah E., Lingenfelter, SE, Lundgren, Johan,, Keep, Nicholas H., Lundgren, Johan, Luscher, B., Harvey, K., Smart, TG, Alldred, M J, Beatty, SE, Owen, M J, Beatty, S E, Alldred, MJ, Rees, MI, Harvey, Kirsten, Duguid, I C, Rees, Mark I., Rees, M I, Duguid, I.C., Pearce, BR, Mark Rees, Rees, M.I.   +53 more
core   +1 more source

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins [PDF]

, 2013
Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol.
Riou, P, Parker, Peter J., O’Reilly, N., George, Roger, Ritu Garg, McColl, Brad, Ganka Bineva, Kjær, S., Svend Kjær, Garg, R, Bineva, G., Thompson, AJ, Reymond, N, Thompson, Andrew J., Philippe Riou, Purkiss, Andrew, Nicola O’Reilly, Parker, Peter J, Brad McColl, Peter J. Parker, Neil Q. McDonald, Parker, Peter J.; id_orcid, O’Reilly, Nicola, Riou, P., Purkiss, A, Parker, PJ, Thompson, A.J., McColl, B, Cain, RJ, Parker, P.J., Kjær, Svend, McColl, B., Andrew Purkiss, O’Reilly, N, Kjær, S, Garg, R., Garg, Ritu, O'Reilly, Nicola, Anne J. Ridley, Cain, Robert J, Robert J. Cain, McDonald, Neil Q, Ridley, Anne J, Bineva, G, Ridley, A.J., Purkiss, Andrew G., Nicolas Reymond, George, R., Thompson, Andrew J, Reymond, N., Reymond, Nicolas, Cain, Robert J., Bineva, Ganka, McDonald, NQ, Riou, Philippe, Andrew J. Thompson, Ridley, AJ, Kjaer, Svend, George, R, Cain, R.J., Ridley, Anne J., Roger George, McDonald, Neil Q.   +62 more
core   +1 more source

The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway [PDF]

, 2009
© 2009 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Jacquier, N, Höfken, T, Lin, Meng, Jacquier, Nicolas, Schneiter, R, Unden, H, Just, Ursula, Just, U, Unden, Heike, Höfken, Thomas, Schneiter, Roger   +10 more
core   +1 more source

The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis [PDF]

, 2013
The spatial and temporal control of polarity is fundamental to the survival of all organisms. Cells define their polarity using highly conserved mechanisms that frequently rely upon the action of small GTPases, such as Ras and Cdc42.
Ladds, Graham, Wayne Croft, Bond, Michael, Croft Wayne, Cathryn Weston, Graham Ladds (430368), Graham Ladds, Cathryn Weston (471448), Croft, Wayne D., Michael Bond, Weston, Cathryn, Ladds Graham, Weston Cathryn, Bond Michael, Michael Bond (471449), Wayne Croft (471450)   +15 more
core   +1 more source

Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes [PDF]

, 2006
Peer ...
Pokhilko, Alexandra V, Goryachev, Andrew B, Alexandra V Pokhilko, Goryachev Andrew B, Andrew B Goryachev, Pokhilko Alexandra V   +5 more
core   +1 more source

Suppl. Fig. S2 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplemental Figure S2 shows the Effect of MBQ compounds on cell migration</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source

Expression of FGD4 positively correlates with the aggressive phenotype of prostate cancer

BMC Cancer, 2018
Background FGD4 (Frabin) is an F-actin binding protein with GTP/GDP exchange activity specific for CDC42. It is involved in reorganization of the actin cytoskeleton, which requires both actin binding and CDC42 activating function of FGD4.
Alexia Bossan, Richard Ottman, Thomas Andl, Md Faqrul Hasan, Nupam Mahajan, Domenico Coppola, Ratna Chakrabarti   +6 more
doaj   +1 more source

Suppl. Fig. S5 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplementary Figure S5 shows the effect of MBQ compounds on Rac activation in attached and detached cells.</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source