TRP Channels Regulation of Rho GTPases in Brain Context and Diseases
Frontiers in Cell and Developmental Biology, 2020 Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood ...
Boris Lavanderos +12 more
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The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms [PDF]
, 2008 © 2008 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Sakwa, I, Höfken, T, Just, U, Tiedje, C
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Rho family GTPases: Key players in neuronal development, neuronal survival, and neurodegeneration
Frontiers in Cellular Neuroscience, 2014 The Rho family of GTPases belongs to the Ras superfamily of low molecular weight (~21 kDa) guanine nucleotide binding proteins. The most extensively studied members are RhoA, Rac1, and Cdc42.
Trisha eStankiewicz +4 more
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Computer vision profiling of neurite outgrowth mordphodynamics reveals spatio-temporal modularity of Rho GTPase signaling [PDF]
, 2014 Neurite outgrowth is essential to build the neuronal processes that produce axons and dendrites that connect the adult brain. In cultured cells, the neurite outgrowth process is highly dynamic, and consists of a series of repetitive morphogenetic sub ...
Fusco, Ludovico
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Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes [PDF]
, 2006 Peer ...
Pokhilko, Alexandra V +5 more
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Rho-GTPases in Rheumatoid Arthritis [PDF]
, 2023 The success of alleviating rheumatoid arthritis (RA) symptoms is complicated by both heterogeneity of the disease and lack of predictive markers to guide treatment options.
Malmhäll-Bah, Eric
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BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility [PDF]
, 2006 Background The reciprocal (9;22) translocation fuses the bcr (breakpoint cluster region) gene on chromosome 22 to the abl (Abelson-leukemia-virus) gene on chromosome 9.
Martin Ruthardt +14 more
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The RHO Family GTPases: Mechanisms of Regulation and Signaling
Cells, 2021 Much progress has been made toward deciphering RHO GTPase functions, and many studies have convincingly demonstrated that altered signal transduction through RHO GTPases is a recurring theme in the progression of human malignancies.
Niloufar Mosaddeghzadeh +1 more
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Implications of Rho GTPase signaling in glioma cell invasion and tumor progression
Frontiers in Oncology, 2013 Glioblastoma (GB) is the most malignant of primary adult brain tumors, characterized by a highly locally-invasive cell population, as well as abundant proliferative cells, neoangiogenesis, and necrosis.
Shannon Patricia Fortin Ensign +4 more
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Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source