Results 31 to 40 of about 37,687 (240)
Rho GTPases as therapeutic targets in Alzheimer’s disease
Alzheimer’s Research & Therapy, 2017 The progress we have made in understanding Alzheimer’s disease (AD) pathogenesis has led to the identification of several novel pathways and potential therapeutic targets.
Byron J. Aguilar, Yi Zhu, Qun Lu
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RHO Family GTPases in the Biology of Lymphoma
Cells, 2019 RHO GTPases are a class of small molecules involved in the regulation of several cellular processes that belong to the RAS GTPase superfamily. The RHO family of GTPases includes several members that are further divided into two different groups: typical ...
Claudia Voena, Roberto Chiarle
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The RHO Family GTPases: Mechanisms of Regulation and Signaling
Cells, 2021 Much progress has been made toward deciphering RHO GTPase functions, and many studies have convincingly demonstrated that altered signal transduction through RHO GTPases is a recurring theme in the progression of human malignancies.
Niloufar Mosaddeghzadeh +1 more
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Implications of Rho GTPase signaling in glioma cell invasion and tumor progression
Frontiers in Oncology, 2013 Glioblastoma (GB) is the most malignant of primary adult brain tumors, characterized by a highly locally-invasive cell population, as well as abundant proliferative cells, neoangiogenesis, and necrosis.
Shannon Patricia Fortin Ensign +4 more
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Novel split-luciferase-based genetically encoded biosensors for noninvasive visualization of Rho GTPases. [PDF]
PLoS ONE, 2013 Rho family GTPases are critical regulators of many important cellular processes and the dysregulation of their activities is implicated in a variety of human diseases including oncogenesis and propagation of malignancy.
Weibing Leng +10 more
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Rho Family GTPases and Rho GEFs in Glucose Homeostasis
Cells, 2021 Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is the cause of an increasing world health crisis. New intriguing roles have emerged for Rho family GTPases and their Rho guanine nucleotide exchange factor (GEF ...
Polly A. Machin +3 more
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Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase
Data in Brief, 2018 The Pleckstrin homology (PH) domains from the Lbc family of Rho Guanine Nucleotide Exchange Factors (Lbc RhoGEFs) interact with activated Rho family GTPases. All 7 Lbc RhoGEFs associate directly with activated Rho GTPases via their PH domains.
Zhe Chen +2 more
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Cells, 2020 The Rho family GTPases are small G proteins that act as molecular switches shuttling between active and inactive forms. Rho GTPases are regulated by two classes of regulatory proteins, guanine nucleotide exchange factors (GEFs) and GTPase-activating ...
Daji Guo, Xiaoman Yang, Lei Shi
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Building Blood Vessels—One Rho GTPase at a Time
Cells, 2019 Blood vessels are required for the survival of any organism larger than the oxygen diffusion limit. Blood vessel formation is a tightly regulated event and vessel growth or changes in permeability are linked to a number of diseases.
Haley Rose Barlow, Ondine Cleaver
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Rho-Family Small GTPases: From Highly Polarized Sensory Neurons to Cancer Cells
Cells, 2019 The small GTPases of the Rho-family (Rho-family GTPases) have various physiological functions, including cytoskeletal regulation, cell polarity establishment, cell proliferation and motility, transcription, reactive oxygen species (ROS) production, and ...
Takehiko Ueyama
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