Results 11 to 20 of about 42,798 (278)
The Role of Fast-Cycling Atypical RHO GTPases in Cancer [PDF]
Cancers, 2022 For many years, cancer-associated mutations in RHO GTPases were not identified and observations suggesting roles for RHO GTPases in cancer were sparse.
Pontus Aspenström, Aspenström Pontus
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Rho GTPases and spermatogenesis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2003 Rho GTPases, such as Rho, Rac and Cdc42, are known to regulate many cellular processes including cell movement and cell adhesion. While the cellular events of germ cell movement are crucial to spermatogenesis since developing germ cells must migrate progressively from the basal to the adluminal compartment but remain attached to the seminiferous ...
Lee, WM, Lui, WY, Cheng, CY
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Rho GTPases—Emerging Regulators of Glucose Homeostasis and Metabolic Health [PDF]
Cells, 2019 Rho guanosine triphosphatases (GTPases) are key regulators in a number of cellular functions, including actin cytoskeleton remodeling and vesicle traffic.
Lisbeth Liliendal Valbjørn Møller +2 more
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Small GTPases, 2014 Since their discovery in the late eighties, the role of Rho GTPases in the regulation of cell migration has been extensively studied and has mainly focused on the hallmark family members Rho, Rac, and Cdc42. Recent technological advances in cell biology, such as Rho-family GTPase activity biosensors, studies in 3D, and unbiased RNAi-based screens, have
Amine Sadok, Christopher J Marshall
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Rho GTPases as therapeutic targets in Alzheimer’s disease
Alzheimer’s Research & Therapy, 2017 The progress we have made in understanding Alzheimer’s disease (AD) pathogenesis has led to the identification of several novel pathways and potential therapeutic targets.
Byron J. Aguilar, Yi Zhu, Qun Lu
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Aberrant activation of TGF-β1 induces high bone turnover via Rho GTPases-mediated cytoskeletal remodeling in Camurati-Engelmann disease [PDF]
Frontiers in Endocrinology, 2022 In the adult skeleton, the bone remodeling process involves a dynamic coordination between osteoblasts and osteoclasts, which is disrupted in diseases with high bone turnover rates and dysregulated transforming growth factor beta 1 (TGF-β1).
Qi Chen +19 more
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Rho GTPases signaling mediates aggressiveness and differentiation in neuroblastoma tumors [PDF]
Cell Communication and SignalingBackground Neuroblastoma (NB) is a pediatric cancer with highly variable outcomes, necessitating improved understanding of the molecular pathways driving its progression.
María A. Gómez-Muñoz +7 more
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Deregulation of Rho GTPases in cancer [PDF]
Small GTPases, 2016 In vitro and in vivo studies and evidence from human tumors have long implicated Rho GTPase signaling in the formation and dissemination of a range of cancers. Recently next generation sequencing has identified direct mutations of Rho GTPases in human cancers.
Andrew P Porter +2 more
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A computational analysis of the role of integrins and Rho-GTPases in the emergence and disruption of apical-basal polarization in renal epithelial cells. [PDF]
PLoS Computational BiologyApical-basal polarization in renal epithelial cells is crucial to renal function and an important trigger for tubule formation in kidney development.
Maria J Hagelaars +5 more
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RHO Family GTPases in the Biology of Lymphoma [PDF]
Cells, 2019 RHO GTPases are a class of small molecules involved in the regulation of several cellular processes that belong to the RAS GTPase superfamily. The RHO family of GTPases includes several members that are further divided into two different groups: typical ...
Claudia Voena, Roberto Chiarle
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