Results 11 to 20 of about 37,687 (240)
Regulation of Rho GTPases in the Vasculature by Cullin3-Based E3 Ligase Complexes [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cullin3-based ubiquitin E3 ligases induce ubiquitination of substrates leading to their proteasomal or lysosomal degradation. BTB proteins serve as adaptors by binding to Cullin3 and recruiting substrate proteins, which enables specific recognition of a ...
Fabienne Podieh, Peter L. Hordijk
doaj +2 more sources
Regulation of Rho GTPases by RhoGDIs in Human Cancers
Cells, 2019 Rho GDP dissociation inhibitors (RhoGDIs) play important roles in various cellular processes, including cell migration, adhesion, and proliferation, by regulating the functions of the Rho GTPase family.
Jong-Tae Kim, Hee Gu Lee, Bo Yeon Kim
exaly +3 more sources
Rho GTPases in ameloblast differentiation
Japanese Dental Science Review, 2016 During tooth development, ameloblasts differentiate from inner enamel epithelial cells to enamel-forming cells by modulating the signal pathways mediating epithelial–mesenchymal interaction and a cell-autonomous gene network.
Keishi Otsu, Hidemitsu Harada
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The Role of Fast-Cycling Atypical RHO GTPases in Cancer [PDF]
Cancers, 2022 Pontus Aspenström, Aspenström Pontus
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Structural Dynamics of Rho GTPases. [PDF]
J Mol BiolRho family GTPases are a part of the Ras superfamily and are signaling hubs for many cellular processes. While the detailed understanding of Ras structure and function has led to tremendous progress in oncogenic Ras-targeted drug discovery, studies of the related Rho GTPases are still catching up as the recurrent cancer-related Rho GTPase mutations ...
Lin Y, Zheng Y.
europepmc +3 more sources
Patterning of the cell cortex by Rho GTPases [PDF]
Nature Reviews Molecular Cell BiologyAndrew B Goryachev A B Goryachev +2 more
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Role of Rho-GTPases in megakaryopoiesis. [PDF]
Small GTPases, 2021 Megakaryocytes (MKs) are the bone marrow (BM) cells that generate blood platelets by a process that requires: i) polyploidization responsible for the increased MK size and ii) cytoplasmic organization leading to extension of long pseudopods, called proplatelets, through the endothelial barrier to allow platelet release into blood.
Vainchenker W +5 more
europepmc +4 more sources
Rho GTPase signaling in rheumatic diseases
iScience, 2022 Summary: Rho guanosine triphosphatase (GTPases), as molecular switches, have been identified to be dysregulated and involved in the pathogenesis of various rheumatic diseases, mainly including rheumatoid arthritis, osteoarthritis, systemic sclerosis, and
Ruijie Zeng +4 more
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Dysregulation of Rho GTPases in Human Cancers [PDF]
Cancers, 2020 Hee Gu Lee, Haiyoung Jung, Suk Ran Yoon
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Pharmacological Modulators of Small GTPases of Rho Family in Neurodegenerative Diseases
Frontiers in Cellular Neuroscience, 2021 Classical Rho GTPases, including RhoA, Rac1, and Cdc42, are members of the Ras small GTPase superfamily and play essential roles in a variety of cellular functions.
William Guiler +3 more
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