Results 41 to 50 of about 42,798 (278)

Novel split-luciferase-based genetically encoded biosensors for noninvasive visualization of Rho GTPases. [PDF]

PLoS ONE, 2013
Rho family GTPases are critical regulators of many important cellular processes and the dysregulation of their activities is implicated in a variety of human diseases including oncogenesis and propagation of malignancy.
Weibing Leng, Xiaohui Pang, Hongwei Xia, Mingxing Li, Liu Chen, Qiulin Tang, Dandan Yuan, Ronghui Li, Libo Li, Fabao Gao, Feng Bi   +10 more
doaj   +1 more source

Rho Family GTPases and Rho GEFs in Glucose Homeostasis

Cells, 2021
Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is the cause of an increasing world health crisis. New intriguing roles have emerged for Rho family GTPases and their Rho guanine nucleotide exchange factor (GEF ...
Polly A. Machin, Elpida Tsonou, David C. Hornigold, Heidi C. E. Welch   +3 more
doaj   +1 more source

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins [PDF]

, 2013
Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol.
Riou, P, Parker, Peter J., O’Reilly, N., George, Roger, Ritu Garg, McColl, Brad, Ganka Bineva, Kjær, S., Svend Kjær, Garg, R, Bineva, G., Thompson, AJ, Reymond, N, Thompson, Andrew J., Philippe Riou, Purkiss, Andrew, Nicola O’Reilly, Parker, Peter J, Brad McColl, Peter J. Parker, Neil Q. McDonald, Parker, Peter J.; id_orcid, O’Reilly, Nicola, Riou, P., Purkiss, A, Parker, PJ, Thompson, A.J., McColl, B, Cain, RJ, Parker, P.J., Kjær, Svend, McColl, B., Andrew Purkiss, O’Reilly, N, Kjær, S, Garg, R., Garg, Ritu, O'Reilly, Nicola, Anne J. Ridley, Cain, Robert J, Robert J. Cain, McDonald, Neil Q, Ridley, Anne J, Bineva, G, Ridley, A.J., Purkiss, Andrew G., Nicolas Reymond, George, R., Thompson, Andrew J, Reymond, N., Reymond, Nicolas, Cain, Robert J., Bineva, Ganka, McDonald, NQ, Riou, Philippe, Andrew J. Thompson, Ridley, AJ, Kjaer, Svend, George, R, Cain, R.J., Ridley, Anne J., Roger George, McDonald, Neil Q.   +62 more
core   +1 more source

Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase

Data in Brief, 2018
The Pleckstrin homology (PH) domains from the Lbc family of Rho Guanine Nucleotide Exchange Factors (Lbc RhoGEFs) interact with activated Rho family GTPases. All 7 Lbc RhoGEFs associate directly with activated Rho GTPases via their PH domains.
Zhe Chen, Steven Gutowski, Paul C. Sternweis   +2 more
doaj   +1 more source

Rho GTPase Regulators and Effectors in Autism Spectrum Disorders: Animal Models and Insights for Therapeutics

Cells, 2020
The Rho family GTPases are small G proteins that act as molecular switches shuttling between active and inactive forms. Rho GTPases are regulated by two classes of regulatory proteins, guanine nucleotide exchange factors (GEFs) and GTPase-activating ...
Daji Guo, Xiaoman Yang, Lei Shi
doaj   +1 more source

Building Blood Vessels—One Rho GTPase at a Time

Cells, 2019
Blood vessels are required for the survival of any organism larger than the oxygen diffusion limit. Blood vessel formation is a tightly regulated event and vessel growth or changes in permeability are linked to a number of diseases.
Haley Rose Barlow, Ondine Cleaver
doaj   +1 more source

Rho-Family Small GTPases: From Highly Polarized Sensory Neurons to Cancer Cells

Cells, 2019
The small GTPases of the Rho-family (Rho-family GTPases) have various physiological functions, including cytoskeletal regulation, cell polarity establishment, cell proliferation and motility, transcription, reactive oxygen species (ROS) production, and ...
Takehiko Ueyama
doaj   +1 more source

Functional and Therapeutic Relevance of Rho GTPases in Innate Immune Cell Migration and Function during Inflammation: An In Silico Perspective

Mediators of Inflammation, 2021
Systematic regulation of leukocyte migration to the site of infection is a vital step during immunological responses. Improper migration and localization of immune cells could be associated with disease pathology as seen in systemic inflammation.
Pankaj Dipankar, Puneet Kumar, Shiba Prasad Dash, Pranita P. Sarangi   +3 more
doaj   +1 more source

Rho GTPases in Glioblastoma Mechanobiology [PDF]

, 2020
Brain tumors are a source of morbidity and mortality worldwide, especially in children and young adults. Due to the high rates of inherently disabling effects (such as personality changes, visual disturbances, and poor coordination), many patients with ...
Xu, Jing
core  

Novel role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in adhesion and migration of 32D myeloid progenitor cells

, 2012
Rho GTPases are involved in homing and mobilization of hematopoietic stem and progenitor cells due to their impact on cytoskeleton remodeling. We have previously shown that inhibition of Rho, Rac and Cdc42 clearly impairs adhesion of normal and leukemic ...
Schwarz, Kerstin, Komor, Martina, Aschenbrenner, Frank, Hofmann, Wolf-Karsten, Bug, Gesine, Ruthardt, Martin, Kampfmann, Manuela, Henschler, Reinhard, Rüster, Brigitte Inge   +8 more
core   +1 more source