Results 21 to 30 of about 42,798 (278)
Rho Family GTPases in Cancer [PDF]
Cancers, 2021 This Special Issue containing seminal contributions from international experts highlights the current understanding of Rho GTPases in cancer, with an emphasis on recognizing their central importance as critical targets for cancer therapy and for chemosensitization of current therapeutic strategies [...]
Suranganie Dharmawardhane
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Rho GTPases and signaling networks [PDF]
Genes & Development, 1997 The Rho GTPases form a subgroup of the Ras superfamily of 20- to 30-kD GTP-binding proteins that have been shown to regulate a wide spectrum of cellular functions. These proteins are ubiquitously expressed across the species, from yeast to man. The mammalian Rho-like GTPases comprise at least 10 distinct proteins: RhoA, B, C, D, and E; Rac1 and 2; RacE;
L, Van Aelst, C, D'Souza-Schorey
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Regulation of Rho GTPases in the Vasculature by Cullin3-Based E3 Ligase Complexes [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cullin3-based ubiquitin E3 ligases induce ubiquitination of substrates leading to their proteasomal or lysosomal degradation. BTB proteins serve as adaptors by binding to Cullin3 and recruiting substrate proteins, which enables specific recognition of a ...
Fabienne Podieh, Peter L. Hordijk
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Rho GTPases in ameloblast differentiation
Japanese Dental Science Review, 2016 During tooth development, ameloblasts differentiate from inner enamel epithelial cells to enamel-forming cells by modulating the signal pathways mediating epithelial–mesenchymal interaction and a cell-autonomous gene network.
Keishi Otsu, Hidemitsu Harada
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Patterning of the cell cortex by Rho GTPases [PDF]
Nature Reviews Molecular Cell BiologyAnn L Miller +2 more
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Rho GTPase signaling in rheumatic diseases
iScience, 2022 Summary: Rho guanosine triphosphatase (GTPases), as molecular switches, have been identified to be dysregulated and involved in the pathogenesis of various rheumatic diseases, mainly including rheumatoid arthritis, osteoarthritis, systemic sclerosis, and
Ruijie Zeng +4 more
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Pharmacological Modulators of Small GTPases of Rho Family in Neurodegenerative Diseases
Frontiers in Cellular Neuroscience, 2021 Classical Rho GTPases, including RhoA, Rac1, and Cdc42, are members of the Ras small GTPase superfamily and play essential roles in a variety of cellular functions.
William Guiler +3 more
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Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity
Frontiers in Cardiovascular Medicine, 2022 Platelet cytoskeletal reorganisation is a critical component of platelet activation and thrombus formation in haemostasis. The Rho GTPases RhoA, Rac1 and Cdc42 are the primary drivers in the dynamic reorganisation process, leading to the development of ...
Shane P. Comer, Shane P. Comer
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High Throughput strategies Aimed at Closing the GAP in Our Knowledge of Rho GTPase Signaling
Cells, 2020 Since their discovery, Rho GTPases have emerged as key regulators of cytoskeletal dynamics. In humans, there are 20 Rho GTPases and more than 150 regulators that belong to the RhoGEF, RhoGAP, and RhoGDI families.
Manel Dahmene +2 more
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RHO GTPase family in hepatocellular carcinoma
Experimental Hematology & Oncology, 2022 RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly conserved in eukaryotic species and have important biological functions, including actin cytoskeleton reorganization, cell proliferation, cell polarity, and vesicular ...
Tiantian Wang +6 more
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