Results 221 to 230 of about 1,798,469 (249)

NF1 and SPRED1/2 cooperate through RAS-MAPK-independent functions. [PDF]

Proc Natl Acad Sci U S A
Silva JM, Canche L, Cheng A, Young LC, McCormick F.   +4 more
europepmc   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Thermodynamic characterisation of covalent ligand binding

British Journal of Pharmacology, EarlyView.
Background and Purpose Differential scanning fluorimetry (DSF) is a common and straightforward method to evaluate the thermal stability of proteins and has been heavily used for ligand binding characterisation as well as for screening. One class of compounds that is less typically evaluated by DSF are covalent binders.
Rebecca Hertzman, Maayan Lavie, Almog Nadir, Ronen Gabizon, Nir London   +4 more
wiley   +1 more source

Research Progress on the ARHGEF Family in Cardiovascular Diseases. [PDF]

Cell Biochem Funct
Zhang H, Guo Q, Mugaka BP, Tai G, Xu M.
europepmc   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Signaling Through Girdin Underlies Excessive Cell Morphogenesis Resulting from Depletion of Neurodevelopmental Disorder-Related Neurexin-2. [PDF]

Int J Mol Sci
Yako H, Takahashi M, Akiyama M, Suzuki A, Miyamoto Y, Yamauchi J.   +5 more
europepmc   +1 more source

ARHGAP11A affects lung adenocarcinoma (LUAD) and pancreatic adenocarcinoma (PAAD) progression by regulating FAM83A. [PDF]

Transl Cancer Res
Sun K, Song LJ, Lu RQ, Liu QZ.
europepmc   +1 more source

Multilayered interplay between the cGAS-STING pathway and autophagy. [PDF]

Autophagy Rep
Huang Z, Gao X, Lin J, Feng D, Lu G.
europepmc   +1 more source

Endosomal maturation is controlled by the trimeric Bulli-Mon1-Ccz1 Rab7 GEF complex and the Rab5 GTPase-activating protein GAPsec. [PDF]

J Cell Sci
Janz M, Drechsler M, Meyer H, Sriram V, Simes KM, Frommhold E, Füllbrunn N, Langemeyer L, Ungermann C, Kümmel D, Paululat A.   +10 more
europepmc   +1 more source

GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits [PDF]

Cell, 1996
A novel class of regulators of G protein signaling (RGS) proteins has been identified recently. Genetic evidence suggests that RGS proteins inhibit G protein–mediated signaling at the level of the receptor–G protein interaction or the G protein α subunit
Thomas M Wilkie, Alfred G Gilman, A G Gilman   +2 more
exaly   +2 more sources