Results 31 to 40 of about 1,798,469 (249)

Roles of Rap1 signaling in tumor cell migration and invasion

Cancer Biology & Medicine, 2017
Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization.
Yi-Lei Zhang, Ruo-Chen Wang, Ken Cheng, Brian Z. Ring, Li Su   +4 more
doaj   +1 more source

Phosphoproteome Profiling of SH-SY5y Neuroblastoma Cells Treated with Anesthetics: Sevoflurane and Isoflurane Affect the Phosphorylation of Proteins Involved in Cytoskeletal Regulation. [PDF]

PLoS ONE, 2016
Inhalation anesthetics are used to decrease the spinal cord transmission of painful stimuli. However, the molecular or biochemical processes within cells that regulate anesthetic-induced responses at the cellular level are largely unknown.
Joomin Lee, Eunsook Ahn, Wyun Kon Park, Seyeon Park   +3 more
doaj   +1 more source

The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms [PDF]

, 2008
© 2008 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Sakwa, I, Höfken, T, Just, U, Tiedje, C
core   +1 more source

Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry. [PDF]

PLoS ONE, 2014
There are no reports of proteomic analyses of inflamed islets in type 1 diabetes.Proteins expressed in the islets of enterovirus-associated fulminant type 1 diabetes (FT1DM) with extensive insulitis were identified by laser-capture microdissection mass ...
Yoriko Nishida, Kaoru Aida, Makoto Kihara, Tetsuro Kobayashi   +3 more
doaj   +1 more source

Transition to Quorum Sensing in an Agrobacterium Population: A Stochastic Model. [PDF]

, 2005
Understanding of the intracellular molecular machinery that is responsible for the complex collective behavior of multicellular populations is an exigent problem of modern biology.
Zhang, Lian-Hui, Travis Lee (274971), Keng Boon Wee (43442), Lee Travis, Da-Jun Toh (274970), Andrew B Goryachev, Wee Keng Boon, Lian-Hui Zhang, Lian-Hui Zhang (119133), Keng Boon Wee, Zhang, Hai-Bao, Toh, Da-Jun, Wee, Keng Boon, Goryachev, Andrew B, Hai-Bao Zhang, Andrew B Goryachev (274969), Da-Jun Toh, Lee, Travis, Goryachev Andrew B, Toh Da-Jun, Hai-Bao Zhang (274972), Zhang Hai-Bao, Travis Lee, Zhang Lian-Hui   +23 more
core   +2 more sources

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins [PDF]

, 2013
Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol.
Riou, P, Parker, Peter J., O’Reilly, N., George, Roger, Ritu Garg, McColl, Brad, Ganka Bineva, Kjær, S., Svend Kjær, Garg, R, Bineva, G., Thompson, AJ, Reymond, N, Thompson, Andrew J., Philippe Riou, Purkiss, Andrew, Nicola O’Reilly, Parker, Peter J, Brad McColl, Peter J. Parker, Neil Q. McDonald, Parker, Peter J.; id_orcid, O’Reilly, Nicola, Riou, P., Purkiss, A, Parker, PJ, Thompson, A.J., McColl, B, Cain, RJ, Parker, P.J., Kjær, Svend, McColl, B., Andrew Purkiss, O’Reilly, N, Kjær, S, Garg, R., Garg, Ritu, O'Reilly, Nicola, Anne J. Ridley, Cain, Robert J, Robert J. Cain, McDonald, Neil Q, Ridley, Anne J, Bineva, G, Ridley, A.J., Purkiss, Andrew G., Nicolas Reymond, George, R., Thompson, Andrew J, Reymond, N., Reymond, Nicolas, Cain, Robert J., Bineva, Ganka, McDonald, NQ, Riou, Philippe, Andrew J. Thompson, Ridley, AJ, Kjaer, Svend, George, R, Cain, R.J., Ridley, Anne J., Roger George, McDonald, Neil Q.   +62 more
core   +1 more source

Stress-dependent inhibition of polarized cell growth through unbalancing the GEF/GAP regulation of Cdc42

Cell Reports, 2021
Summary: Cdc42 GTPase rules cell polarity and growth in fission yeast. It is negatively and positively regulated by GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs), respectively.
Clàudia Salat-Canela, Mercè Carmona, Rebeca Martín-García, Pilar Pérez, José Ayté, Elena Hidalgo   +5 more
doaj   +1 more source

Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins

, 1999
GTPase-activating proteins (GAPs) enhance the intrinsic GTPase activity of small G proteins, such as Ras and Rho, by contributing a catalytic arginine to the active site.
Cunningham, Debbie; id_orcid, Chung, C W, Lowe, P N, Eccleston, J F   +3 more
core   +6 more sources

Rab11 and Its Role in Neurodegenerative Diseases

ASN Neuro, 2022
Vesicles mediate the trafficking of membranes/proteins in the endocytic and secretory pathways. These pathways are regulated by small GTPases of the Rab family.
Pinky Sultana, Jiri Novotny
doaj   +1 more source

Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What’s behind Neuro-RACopathies

Cells, 2021
Rho family guanosine triphosphatases (GTPases) regulate cellular signaling and cytoskeletal dynamics, playing a pivotal role in cell adhesion, migration, and cell cycle progression.
Marcello Scala, Masashi Nishikawa, Koh-ichi Nagata, Pasquale Striano   +3 more
doaj   +1 more source