Results 101 to 110 of about 188,398 (263)
, 2011 The stringent stress response is vital for bacterial survival under adverse environmental conditions. Obligate intracellular Chlamydia lack key stringent response proteins, but nevertheless can interrupt the cell cycle and enter stasis or persistence ...
Polkinghorne, Adam +5 more
core +1 more source
Advanced Science, EarlyView.Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong +8 more
wiley +1 more source
Advanced Science, EarlyView.Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng +19 more
wiley +1 more source
Computational analysis of Rho GTPase cycling.
, 2013 The Rho family of GTPases control actin organization during diverse cellular responses (migration, cytokinesis and endocytosis). Although the primary members of this family (RhoA, Rac and Cdc42) have different downstream effects on actin remodeling, the ...
Leslie M. Loew (103591) +8 more
core +2 more sources
GTPase Cycling in the GEF-Only System
, 2013 The values of the GTPase activity (A), recovery time (B), and performance index (C) are shown as functions of the total concentrations of the GTPase (R0) and GEF (E0).
Alexandra V Pokhilko (379527) +1 more
core +1 more source
Advanced Science, EarlyView.Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong +10 more
wiley +1 more source
Atomic mutagenesis of the ribosomal Sarcin-Ricin-Loop to study EF-G GTPase activation
, 2014 Translocation factor EF-G, possesses a low basal GTPase activity, which is stimulated by the ribosome. One potential region of the ribosome that triggers GTPase activity of EF-G is the Sarcin-Ricin-Loop (SRL) (helix 95) in domain VI of the 23S rRNA ...
Koch, Miriam
core
, 2013 GTPase activities marked rgn were assayed by the GTP regeneration, coupled NADH assay. Those marked mal were assayed with malachite green. The malachite green reactions were measured at room temperature (23°C); the regeneration reactions were at ∼29°C ...
Christopher A. Sontag (370198) +2 more
core +1 more source
Fluorescent sensors for the small GTPase switch [PDF]
, 2017 Kleine GTPasen regulieren eine Vielzahl an hoch dynamischen Prozessen, welche von Signaltransduktion und Cytoskelettorganisation bis zum nuklearen und vesikulären Transport reichen. Sie erfüllen ihre regulatorische Rolle indem Sie als molekulare Schalter
Voss, S., Voß, Stephanie
core +1 more source
Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury
Advanced Science, EarlyView.After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez +8 more
wiley +1 more source