Results 191 to 200 of about 258,313 (263)

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, EarlyView.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

Clinical and genetic characterization of <i>DNM1l</i>-related disorders: insights into genotype-phenotype correlations. [PDF]

Front Pediatr
Manting X, Hua L, Sheng H, Xiaodi H, Dan S, Fang F.   +5 more
europepmc   +1 more source

Proteomic Characterization of AS1411 Reveals ATP6AP1 as a Mediator of Triple‐Negative Breast Cancer Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae, Yun‐Jeong Seo, Eun‐Bi Kim, Hyoung‐Min Park, I‐Hsuan Liu, J. Eugene Lee, Jae‐Young Kim   +6 more
wiley   +1 more source

Pimozide Reprograms the Ran GTPase-SCF Axis and Matrix Remodeling Pathways in Breast, Colorectal, and Pancreatic Cancer Models. [PDF]

Cancers (Basel)
Al-Ali HAH, El-Tanani M, Satyam SM, Al-Qaisi TS, Lukman Y, Ahmed KA, Obiedat R, Ibrahim A, Madi R, Khirfan R.   +9 more
europepmc   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

Deciphering a mechanistic basis for the pathological effect of the GNAO1 E246K variant in neurodevelopmental disorder. [PDF]

BBA Adv
Sadiya I, Nekrasova I, Avital-Shacham M, van Wijk N, Zohar K, Kalisman N, Shneidman-Duhovny D, Banne E, Nissenkorn A, Blumkin L, Linial M, Kosloff M.   +11 more
europepmc   +1 more source

Space biomedicine‐oriented bioink and biomimetic blood‒brain barrier

VIEW, EarlyView.
Bioinks and bioprinting play a pivotal role in the successful delivery of cell models and the fabrication of tissue models for space biomedicine research. This study investigated the effects of hypergravity and vibration on two‐dimensional adherent cells and three‐dimensional embedded cells and provided methods for storing hybrid bioink and high ...
Ranran Yan, Ge Gao, YuJuan Li, YuLin Deng   +3 more
wiley   +1 more source

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson's Disease: Comparative Analysis of G2019S and I1371V Variants. [PDF]

Cells
Singh K, Banerjee R, Potdar C, Shaw A, Rakshith R, Kamble N, Holla V, Yadav R, Pal PK, Datta I.   +9 more
europepmc   +1 more source

A novel fusion tool to enable G protein‐coupled receptor structure determination

Acta Crystallographica Section D, EarlyView.
The development of a new fusion tool in which a β‐lactamase fusion tag and a binding partner enabled the structure determination of an antagonist‐bound G protein‐coupled receptor by cryo‐EM is reported.Structure determination of G protein‐coupled receptors (GPCRs) plays an important role in accelerating drug development against this medically important
Nita R. Shah, Mathieu Oosterlaken, Claudine Bisson, Mattia Bertinelli, Alicia M. Churchill-Angus, Andrew Hutchin, Jola Kopec, Vadim Kotov, Ciaran R. McFarlane, Erika Griss Pascualli, Ana Pavic, Matthias Zebisch, Cédric Fiez-Vandal, Edoardo Fabini, Stéphanie Duclos   +14 more
wiley   +1 more source

Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors. [PDF]

Cell Commun Signal
Ushakumary MG, Sontag RL, Posso C, Fillmore TL, Topping ME, Olson HM, De Jager PL, Bennett DA, Arvanitakis Z, Petyuk VA.   +9 more
europepmc   +1 more source