Results 271 to 280 of about 246,437 (319)

β2-Chimaerin Deficiency Favors Polyp Growth in the Colon of Apc^Min/+ Mice. [PDF]

Molecules
Velasco-Sampedro EA, Sánchez-Vicente C, Caloca MJ.   +2 more
europepmc   +1 more source

A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II

, 1998
Hong-Jung Chen, Michelle Rojas-Soto, Asako Oguni, Mary B. Kennedy   +3 more
openalex   +1 more source

Modeling fire‐related smoke inhalation injury using the human lung‐on‐a‐chip and organoid platform: Pathogenesis insights and therapeutic evaluation

VIEW, EarlyView.
Fire‐related smoke inhalation‐induced acute lung injury (SI‐ALI) poses a significant public health risk, yet effective treatments are limited due to the lack of suitable models. This study developed a more realistic model of SI‐ALI using organ‐on‐a‐chip and organoid technologies, identified key molecules such as catechol‐O‐methyltransferase and ...
Junmin Li, Dezhong Zhang, Yan Meng, Yongqing Chang, Wenbo Wei, Peng Wu, Lin Peng, Wei Chang, Wei Wang, Jie Huang, Jingjing Fang, Keming Zhu, Xiaojian Wan   +12 more
wiley   +1 more source

DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation. [PDF]

Genome Med
Lo EKW, Idrizi A, Tryggvadottir R, Zhou W, Hou W, Ji H, Cahan P, Feinberg AP.   +7 more
europepmc   +1 more source

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

VIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source

Deregulated ion channels contribute to RHOBTB2-associated developmental and epileptic encephalopathy. [PDF]

Hum Mol Genet
Langhammer F, Gregor A, Ntamati NR, Ekici AB, Winner B, Nevian T, Zweier C.   +6 more
europepmc   +1 more source

Semaglutide to remodel mitochondrial dynamics and mitophagy balance for vascular dementia therapy

VIEW, EarlyView.
The effects of semaglutide on IR, mitochondrial dynamics, and mitophagy in the hippocampus of BCAS mice after CCH. It was shown that semaglutide maintained the balance of mitochondrial dynamics and mitophagy by improving IR and passing through GLP‐1R/PI3K/Akt pathway, reduced hippocampal neuroinflammation and neuron loss, and thus promoted the recovery
Xiaoyan Yang, Peng Feng, Hongxu Zhu, Mingkang Wang, Nan Li, Bo Bai, Yuxiang Sun, Zhongrui Yan, Wenshi Wei, Jie Chang, Christian Hölscher, Wenxian Du   +11 more
wiley   +1 more source

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease. [PDF]

Biomolecules
Zanfardino P, Amati A, Perrone M, Petruzzella V.   +3 more
europepmc   +1 more source

A p.N92K variant of the GTPase RAC3 disrupts cortical neuron migration and axon elongation. [PDF]

J Biol Chem
Sugawara R, Hamada K, Ito H, Scala M, Ueda H, Tabata H, Ogata K, Nagata KI.   +7 more
europepmc   +1 more source

A novel <i>DNM2</i> variant associated with centronuclear myopathy: a case report. [PDF]

Front Genet
Rimoldi M, Velardo D, Zanotti S, Ripolone M, Del Bo R, Ciscato P, Napoli L, Corti S, Comi GP, Ronchi D.   +9 more
europepmc   +1 more source