Results 271 to 280 of about 322,041 (407)

The molecular mechanisms and physiological roles of mitochondria dynamics in <i>Saccharomyces cerevisiae</i>. [PDF]

Microb Cell
Chen CL, Huang WL, Rapoport A, Daugelavičius R, Chang CR.   +4 more
europepmc   +1 more source

The HRAS Variant c.175G>A (p.Ala59Thr) Causes a Predominantly Ectodermal Phenotype Lacking Classic Costello Syndrome Features

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Costello syndrome (CS) is a rare dominant HRAS RASopathy characterized by curly hair, cardiac abnormalities, craniofacial anomalies, and developmental delay. HRAS codon 58, 59, and 60 variants are associated with milder phenotypes. We describe a three‐generation family with a previously unreported heterozygous HRAS variant c.175G>A (p.Ala59Thr)
Nikole Rautiainen, Eveliina Brandt, Kaisa Kettunen, Outi Elomaa, Sirpa Kivirikko, Leila Jeskanen, Katriina Lappalainen, Nelli Sjöblom, Juha Kere, Katariina Hannula‐Jouppi, Liisa Harjama   +10 more
wiley   +1 more source

ARHGAP11A, a member of Rho GTPase activating protein family, as a prognostic biomarker linked to DNA damage response across pan-cancer. [PDF]

BMC Cancer
Tan K, Wu Y, Zhang J, Ding Y, Cheng C, Yan Z, Wang X, Zhang L.   +7 more
europepmc   +1 more source

Structure-function relationship of the small GTPase rab5.

, 1993
Guangpu Li, Philip D. Stahl
openalex   +1 more source

Rho Family GTPases Bind to Phosphoinositide Kinases [PDF]

, 1995
Kimberley F. Tolias, Lewis C. Cantley, Christopher L. Carpenter   +2 more
openalex   +1 more source

Computational model predicts function of Rho-GTPase binding for plexin receptor GAP activity on Rap1b via dynamic allosteric changes. [PDF]

Protein Sci
Bhattarai N, Morrison L, Gomes AF, Savage P, Sahoo AR, Buck M.   +5 more
europepmc   +1 more source

Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62

, 1992
Luc E. M. Marengère, Tony Pawson
openalex   +1 more source

p21^WAF1/CIP1 Is Upregulated by the Geranylgeranyltransferase I Inhibitor GGTI-298 through a Transforming Growth Factor β- and Sp1-Responsive Element: Involvement of the Small GTPase RhoA [PDF]

, 1998
Jalila Adnane, Francisco A. Bizouarn, Yimin Qian, Andrew D. Hamilton, Saı̈d M. Sebti   +4 more
openalex   +1 more source

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai, Yongde Jin, Jingmei Chai, Jianing Yang, Jiangang Wang, Mu Chen, Liangchang Li, Chongyang Wang, Guanghai Yan   +8 more
wiley   +1 more source

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets. [PDF]

MedComm (2020)
Lin Z, Ni C, Jiang H, Yang H, Deng L, Liu P, Li X, Yu Y, Li W, Wang R, Liao B, Kang J, Liu J, Wu X, Ren J, Zhao Y.   +15 more
europepmc   +1 more source