Results 281 to 290 of about 322,041 (407)

Ras GTPase-activating protein: a substrate and a potential binding protein of the protein-tyrosine kinase p56lck.

, 1992
Kurt E. Amrein, N Flint, B Panholzer, P Burn   +3 more
openalex   +1 more source

The ADP-ribosylation Factor (ARF)-related GTPase ARF-related Protein Binds to the ARF-specific Guanine Nucleotide Exchange Factor Cytohesin and Inhibits the ARF-dependent Activation of Phospholipase D [PDF]

, 1999
Annette Schürmann, Martina Schmidt, Melanie Asmus, S. Bayer, Frank Fliegert, Susanne Koling, Silke Maßmann, Christiane Schilf, M. Cecilia Subauste, Matthias Voß, Karl H. Jakobs, Hans‐Georg Joost   +11 more
openalex   +1 more source

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset

Annals of Neurology, EarlyView.
Objectives Multiple sclerosis (MS) onset risk factors include Epstein–Barr virus (EBV) indices (including host response), lower serum 25‐vitamin D (25(OH)D) levels, low sun exposure, and HLA‐DRB1*1501. The underlying molecular mechanisms are unclear. Here, we examined mediation through differential DNA methylation (DNAm) to better understand possible ...
Steve Simpson‐Yap, Ellen Morwitch, Samuel A. Tanner, Sarah M. Thomson, Alex Eisner, Rod A. Lea, Trevor J. Kilpatrick, Jeannette Lechner‐Scott, Rodney J. Scott, Alexandre Xavier, Vicki E. Maltby, Robyn M. Lucas, Bruce V. Taylor, Brett A. Lidbury, Simon A. Broadley, Ingrid van der Mei, Mehari Woldemariam Merid, Boris Novakovic, Richard Saffery, Anna Karin Hedström, Pernilla Stridh, Tomas Olsson, Maja Jagodic, Lars Alfredsson, Anne‐Louise Ponsonby, for the Ausimmune Investigator Group, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn Lucas, Tony McMichael, Anne‐Louise Ponsonby, Bruce Taylor, Patricia Valery, Ingrid van der Mei, David Williams   +37 more
wiley   +1 more source

The GTPase κB-Ras is an essential subunit of the RalGAP tumor suppressor complex. [PDF]

J Biol Chem
Rasche R, Apken LH, Titze S, Michalke E, Singh RK, Oeckinghaus A, Kümmel D.   +6 more
europepmc   +1 more source

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

Cell Metabolism, 2010
Adem Kalender, A. Selvaraj, S. Kim, P. Gulati, S. Brûlé, B. Viollet, B. Kemp, N. Bardeesy, P. Dennis, J. Schlager, A. Marette, S. Kozma, G. Thomas   +12 more
semanticscholar   +1 more source

Nanodroplet‐Array‐Plattform zur integrierten Synthese und Screening von MEK Inhibitoren: Ein miniaturisierter Ansatz für die frühe Pharmaforschung

Angewandte Chemie, EarlyView.
Wir präsentieren eine Nanodroplet‐Array‐Plattform, die die Integration von Festphasensynthese, MALDI‐MS‐Analyse und zellbasiertem Screening von 325 potenziellen MEK‐Inhibitoren (Mitogen‐aktivierte‐Proteinkinase‐Kinase) in Nanoliter‐Volumina ermöglicht.
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source

Deciphering the oncogenic role of Rac family small GTPase 3 in hepatocellular carcinoma through multiomics integration. [PDF]

World J Hepatol
Liu R, Li JC, Li SD, Li JD, He RQ, Chen G, Feng ZB, Wei JL.   +7 more
europepmc   +1 more source

Purification of GTPase-activating protein specific for the rho gene products.

, 1991
Narito Morii, Kenichi Kawano, Akihiro Sekine, Takaaki Yamada, Shuh Narumiya   +4 more
openalex   +1 more source

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

Angewandte Chemie International Edition, EarlyView.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source

Retraction Note: Downregulation of the Rho GTPase pathway abrogates resistance to ionizing radiation in wild-type p53 glioblastoma by suppressing DNA repair mechanisms. [PDF]

Cell Death Dis
Magalhaes YT, Boell VK, Cardella GD, Forti FL.   +3 more
europepmc   +1 more source