Results 291 to 300 of about 246,437 (319)
A Ras-like GTPase in African trypanosomes
Lowenstein M, Ramirez A, Field MC.
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Diabetes Advances Cardiomyocyte Senescence Through Interfering Rnd3 Expression and Function
Aging Cell, EarlyView.Diabetes‐induced upregulation of miR‐103a‐3p suppresses Rnd3 expression in cardiomyocytes, thereby promoting the senescence‐associated secretory phenotype (SASP) through activation of the STAT3 signaling pathway, mediated by UPS‐induced degradation of p‐STAT3.
Linxu Wu +16 more
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Aging Cell, EarlyView.The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai +7 more
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The Interferon-Inducible GTPases
Annual Review of Cell and Developmental Biology, 2006Mammalian cells respond to interferons (IFNs) secreted during infection by the transcriptional upregulation of as many as a thousand genes. This remarkable transition prepares cells and organisms for resistance to infection, and many IFN-regulated gene products are players in well-understood resistance programs.
Sascha Martens, Jonathan C. Howard
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2017
GTPases (GTP hydrolases, GTP binding proteins) are a large family of enzymes that direct various cellular functions, including signal transduction, protein biosynthesis, cell division and transport of vesicles. They are molecular switches that cycle between two conformational states (Figure 1): the inactive guanosine-5'-diphosphate (GDP)-bound state ...
Stefanini, Lucia +2 more
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GTPases (GTP hydrolases, GTP binding proteins) are a large family of enzymes that direct various cellular functions, including signal transduction, protein biosynthesis, cell division and transport of vesicles. They are molecular switches that cycle between two conformational states (Figure 1): the inactive guanosine-5'-diphosphate (GDP)-bound state ...
Stefanini, Lucia +2 more
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The International Journal of Biochemistry & Cell Biology, 2002
Eps8, originally identified as a substrate for the kinase activity of the epidermal growth factor receptor (EGFR), displays a domain organization typical of a signaling molecule that includes a putative N-terminal PTB domain, a central SH3 domain, and a C-terminal "effector region".
P.P. Di Fiore, G. Scita
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Eps8, originally identified as a substrate for the kinase activity of the epidermal growth factor receptor (EGFR), displays a domain organization typical of a signaling molecule that includes a putative N-terminal PTB domain, a central SH3 domain, and a C-terminal "effector region".
P.P. Di Fiore, G. Scita
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BioFactors, 2013
AbstractRho GTPases are a family of small GTPases, which play an important role in the regulation of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and therefore highly important for cancer cell invasion and the formation of metastases. In addition, Rho GTPases are involved in growth and survival of tumor cells, in
Li, Hui +3 more
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AbstractRho GTPases are a family of small GTPases, which play an important role in the regulation of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and therefore highly important for cancer cell invasion and the formation of metastases. In addition, Rho GTPases are involved in growth and survival of tumor cells, in
Li, Hui +3 more
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Chronicles of the GTPase switch
Nature Chemical Biology, 2011The GTPase switch is a versatile molecular device used by many proteins, such as the small GTPases, to regulate an astounding number of functions. Although the basics of the guanine nucleotide cycle are now well established, the next challenge is to reach an integrated view of how these proteins use it to orchestrate signaling pathways.
Jacqueline Cherfils, Mahel Zeghouf
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Current Opinion in Structural Biology, 1995
The past year has witnessed a tremendous increase in our understanding of the structures and interactions of the GTPases. The highlights include crystal structures of G alpha subunits, as well as the first complex between a GTPase (Rap1A) and an effector molecule (c-Raf1 Ras-binding domain).
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The past year has witnessed a tremendous increase in our understanding of the structures and interactions of the GTPases. The highlights include crystal structures of G alpha subunits, as well as the first complex between a GTPase (Rap1A) and an effector molecule (c-Raf1 Ras-binding domain).
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Experimental Cell Research, 1999
Rho GTPases regulate many important processes in all eukaryotic cells, including the organization of the actin cytoskeleton, gene transcription, cell cycle progression, and membrane trafficking. Their activity is regulated by signals originating from different classes of surface receptors including G-protein-coupled receptors, tyrosine kinase receptors,
Lars Kjøller, Alan Hall
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Rho GTPases regulate many important processes in all eukaryotic cells, including the organization of the actin cytoskeleton, gene transcription, cell cycle progression, and membrane trafficking. Their activity is regulated by signals originating from different classes of surface receptors including G-protein-coupled receptors, tyrosine kinase receptors,
Lars Kjøller, Alan Hall
openaire +3 more sources