Results 291 to 300 of about 322,041 (407)

Enzymatic characterization of interferon-induced antiviral GTPases murine Mx1 and human MxA proteins.

, 1994
Krister Melén, Tapani Ronni, T. Lotta, Ilkka Julkunen   +3 more
openalex   +1 more source

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, EarlyView.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source

Gα_s-specific structural elements attenuate interactions with regulator of G protein signaling (RGS) proteins. [PDF]

FEBS J
Higazy-Mreih S, Avital-Shacham M, LeGouill C, Bouvier M, Kosloff M.   +4 more
europepmc   +1 more source

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

Science Signaling, 2013
Nicolas Panchaud, Marie-Pierre Péli-Gulli, C. De Virgilio   +2 more
semanticscholar   +1 more source

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

BMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang   +9 more
wiley   +1 more source

The oncogene protein kinase PIM1 regulates mammalian erythroblast enucleation. [PDF]

Commun Biol
Zhang H, Xu Y, Li Y, Zhang J, Xiao J, Wang C, Wang Y, An X, Zhang S.   +8 more
europepmc   +1 more source

Functional CRISPR‐Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity

Biotechnology Progress, EarlyView.
Abstract Directional cell migration plays a central role in a wide range of physiological and pathological conditions, such as embryonic development or tumor metastasis. Steps involved in cell migration include cell polarization, formation of membrane protrusions at the cell front side and adhesion disassembly at the rear side, and a general ...
Antonio Mazzei, Sebastian Martewicz, Ramin Amiri, Meihua Cui, Nicola Elvassore, Camilla Luni   +5 more
wiley   +1 more source

Neurodevelopmental disorder mutations in the exchange factor DENN/MADD disrupt activation of Rab GTPases. [PDF]

J Biol Chem
Khan M, Kumar R, Trempe JF, Francis V, Banks E, Ayoubi R, Luna LA, McPherson PS.   +7 more
europepmc   +1 more source

Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain

Proceedings of the National Academy of Sciences of the United States of America, 2014
J. Liao, Chunxiang Wu, C. Burlak, Shenmin Zhang, H. Sahm, Mu Wang, Zhon-Yin Zhang, K. Vogel, M. Federici, Steven M. Riddle, R. Nichols, Dali Liu, M. Cookson, Todd A. Stone, Quyen Q. Hoang   +14 more
semanticscholar   +1 more source

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Cancer Communications, EarlyView.
Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu, Yan Li, Bingjie Lian, Yitao Mao, Luqing Zhao   +4 more
wiley   +1 more source