Results 301 to 310 of about 261,647 (345)

Hepatocellular carcinoma resistance to tyrosine kinase inhibitors: Current status and perspectives. [PDF]

World J Gastrointest Oncol
Miao YR, Yang XJ.
europepmc   +1 more source

Genetic Determinants of the Familial Hypercholesterolaemia Phenotype

Annals of Human Genetics, EarlyView.
ABSTRACT Individuals with familial hypercholesterolaemia (FH) have severely elevated plasma concentrations of low‐density lipoprotein cholesterol (LDL‐C) from birth and as a consequence have an elevated morbidity and mortality due to the development of coronary heart disease (CHD).
Steve Eric Humphries, Marta Futema
wiley   +1 more source

The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii. [PDF]

PLoS Pathog
Critchlow JM, Rocchio JS, McKell MC, Campbell CJ, Barraza JP, Krystofiak ES, Green ER, Akizuki T, Chazin WJ, VanNieuwenhze MS, Stemmler TL, Giedroc DP, Skaar EP.   +12 more
europepmc   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Corrigendum: N-terminus GTPase domain of the cytoskeleton protein FtsZ plays a critical role in its adaptation to high hydrostatic pressure. [PDF]

Front Microbiol
Cui XH, Wei YC, Li XG, Qi XQ, Wu LF, Zhang WJ.   +5 more
europepmc   +1 more source

Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers

Andrology, EarlyView.
Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco, Pablo Martínez‐Díaz, Ana Parra, María José Martínez‐Alborcia, Xiomara Lucas, Heriberto Rodríguez‐Martínez, Jordi Roca   +6 more
wiley   +1 more source

The link between the trans-Golgi network and tumour progression. [PDF]

Mol Biol Rep
Jahangiri L.
europepmc   +1 more source

Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke

Brain Pathology, EarlyView.
After ischemic stroke, TRPV4 activation induces cerebral edema through the TRPV4‐RhoA‐MMP9 axis: RhoA upregulates MMP9, which cleaves β‐DG to impair membrane anchoring. Subsequent β‐DG loss triggers AQP4 depolarization, disrupting GS‐mediated water homeostasis.
Yongchuan Li, Haiping Zhou, Jiaxin Xie, Mingjia Yu, Guanyu Ye, Yuzhen Zhang, Zhentong Li, Kunxue Zhang, Jingwen Wu, Sheng Xiao, Shuxin Zeng, Yuan Chang, Kaibin Huang, Suyue Pan   +13 more
wiley   +1 more source

Untangling Traffic Jams: RAB11FIP4 Orchestrates Cellular Recovery in Cystinosis. [PDF]

Autophagy Rep
Ait Kbaich M, Johnson JL, Catz SD.
europepmc   +1 more source

Quantifying small GTPase activation status using a novel fluorescence HPLC-based assay. [PDF]

J Biol Chem
Araki M, Kasuya Y, Yoshimoto K, Katada T, Kontani K.   +4 more
europepmc   +1 more source