Results 301 to 310 of about 261,647 (345)

Genetic Determinants of the Familial Hypercholesterolaemia Phenotype

open access: yesAnnals of Human Genetics, EarlyView.
ABSTRACT Individuals with familial hypercholesterolaemia (FH) have severely elevated plasma concentrations of low‐density lipoprotein cholesterol (LDL‐C) from birth and as a consequence have an elevated morbidity and mortality due to the development of coronary heart disease (CHD).
Steve Eric Humphries, Marta Futema
wiley   +1 more source

The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii. [PDF]

open access: yesPLoS Pathog
Critchlow JM   +12 more
europepmc   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

open access: yesAndrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre   +5 more
wiley   +1 more source

Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers

open access: yesAndrology, EarlyView.
Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco   +6 more
wiley   +1 more source

Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke

open access: yesBrain Pathology, EarlyView.
After ischemic stroke, TRPV4 activation induces cerebral edema through the TRPV4‐RhoA‐MMP9 axis: RhoA upregulates MMP9, which cleaves β‐DG to impair membrane anchoring. Subsequent β‐DG loss triggers AQP4 depolarization, disrupting GS‐mediated water homeostasis.
Yongchuan Li   +13 more
wiley   +1 more source

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