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Rho family GTPases

Biochemical Society Transactions, 2012
Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton,
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LRRK2 and Rab GTPases

Biochemical Society Transactions, 2018
Leucine-rich repeat kinase 2 (LRRK2) is mutated in familial Parkinson's disease, and pathogenic mutations activate the kinase activity. A tour de force screen by Mann and Alessi and co-workers identified a subset of Rab GTPases as bona fide LRRK2 substrates.
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Rho GTPases and Cancer

2005
The Rho (Ras-homologous) family of proteins constitutes a major branch of the Ras superfamily of small GTPases, and is evolutionarily conserved across several phyla. Thus far, 25 members have been identified, and these may be divided into 6 subfamilies based on amino acid sequence identity, structural motifs, and biological function.
Pinella Buongiorno, Bharati Bapat
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GTPases and T cell activation

Immunological Reviews, 2003
Summary:  Guanine nucleotide binding proteins rapidly cycle between a guanosine diphosphate (GDP)‐bound and guanosine triphosphate (GTP)‐bound state, and they operate as binary switches that control cell activation in response to environmental cues. GTPases adopt different conformations when binding GTP vs. GDP.
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GTPases in Semaphorin Signaling

2007
A hallmark of semaphorin receptors is their interaction with multiple GTPases. Plexins, the signal transducing component of semaphorin receptors, directly associate with several GTPases. In addition, they not only recruit guaninine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) but also are the only known integral membrane ...
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The GTPase function of LRRK2

Biochemical Society Transactions, 2012
LRRK2 (leucine-rich repeat kinase 2) is a large protein encoding multiple functional domains, including two catalytically active domains, a kinase and a GTPase domain. The LRRK2 GTPase belongs to the Ras-GTPase superfamily of GTPases, more specifically to the ROC (Ras of complex proteins) subfamily.
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Rho GTPases in Development

1999
It is becoming increasingly clear that the complex family of Rho-related GTPases and their associated regulators and targets are essential mediators of a variety of morphogenetic events required for normal development of multicellular organisms. It is worth noting that the results obtained thus far indicate that the Rho family proteins are largely ...
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GTPase

2008
Teresa Gómez Del Pulgar   +1 more
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Small GTPases

2008
Gudula Schmidt, Klaus Aktories
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GTPase enters the ring

Current Biology, 1993
Daniel Vinella   +2 more
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