Results 331 to 340 of about 322,041 (407)

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

, 1995
Caroline S. Hill, Judy Wynne, Richard Treisman   +2 more
openalex   +1 more source

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS

Clinical Pharmacology &Therapeutics, EarlyView.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6‐mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose‐limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function ...
Carlotta Bidoli, Wenjian Yang, Seth E. Karol, Marianna Lucafò, Gabriele Stocco, Jun J. Yang   +5 more
wiley   +1 more source

Connecting tubules: mechanisms of endoplasmic reticulum membrane fusion. [PDF]

Biochem Soc Trans
Jang E, Jun Y.
europepmc   +1 more source

A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II

, 1998
Hong-Jung Chen, Michelle Rojas-Soto, Asako Oguni, Mary B. Kennedy   +3 more
openalex   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, EarlyView.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

[Retracted] Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase. [PDF]

Oncol Lett
Zhang A, Wang Q, Han Z, Hu W, Xi L, Gao Q, Wang S, Zhou J, Xu G, Meng L, Chen G, Ma D.   +11 more
europepmc   +1 more source

Altered Inflammatory Signature in a C9ORF72‐ALS iPSC‐Derived Motor Neuron and Microglia Coculture Model

Glia, EarlyView.
Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao, Jessica L. Brothwood, Harpreet Saini, Gregory A. O'Sullivan, Carla F. Bento, James M. McCarthy, Nicola G. Wallis, Elena Di Daniel, Brent Graham, Daniel M. Tams   +9 more
wiley   +1 more source

Various methods to detect small GTPase activation: from radioisotope-based methods to the Small GTPase ActIvitY ANalysing (SAIYAN) system. [PDF]

J Biochem
Maeda M, Saito K.
europepmc   +1 more source

Integrated analysis of ARHGAP6 potential function and prognostic value in acute myeloid leukemia. [PDF]

PLoS One
Yang D, Li Y, Ma P, Xiao F.
europepmc   +1 more source

Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility. [PDF]

Proc Natl Acad Sci U S A
Tršelič T, Pelo N, Martin de Fremont G, Iyer VS, Richardsdotter Andersson E, Ottosson V, Frei DA, Baas E, Nyberg WA, Thorlacius GE, Mentlein L, Boddul SV, Sandu I, Velasquez Pulgarin D, Végvári Á, Gerlach C, Wermeling F, Sunnerhagen M, Wallner B, Espinosa A, Wahren-Herlenius M.   +20 more
europepmc   +1 more source