Results 111 to 120 of about 57,067 (241)

Structural and Functional Insights Into (S)‐5′‐C‐Guanidinopropyl Uridine‐Modified Oligonucleotides With 2′‐O‐Methyl and 2′‐Fluoro Substitutions for RNAi Therapeutics

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Novel (S)‐5′‐guanidinopropyl uridine analogs bearing 2′‐O‐methyl or 2′‐fluoro substitutions enhance nuclease resistance and mismatch discrimination while preserving A‐form RNA structure and potent RNAi activity. These modifications provide a promising strategy for improving the stability, specificity, and therapeutic potential of siRNA‐based medicines.
Sugahara Masaki, Elsayed M. Mahmoud, Shuichi Sakamoto, Yoshihito Ueno   +3 more
wiley   +1 more source

Validation of Guanidine-EDTA as a Preservative Agent for the Analysis of miRNAs and mRNAs in Blood Samples of Chagas Disease Patients. [PDF]

Pathogens
Faier-Pereira A, Finamore-Araujo P, Brito MMR, Hasslocher-Moreno AM, Moreira OC.   +4 more
europepmc   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Enantioselective organocatalytic radical alkylation enabled by photoexcitation. [PDF]

Chem Sci
Song Y, Wang R, Lu X, Zhou Y, Feng X, Cao W, Liu X.   +6 more
europepmc   +1 more source

GK PUA Domain Modulates Cables, Cooperativity, and Proline Feedback

Aggregate, Volume 7, Issue 8, August 2026.
EcGK tetramers hierarchically assemble into metabolic filaments and bundle into metabolic cables. Upon substrate binding, this dynamic equilibrium shifts from inactive cables to active tetramers to drive catalysis; meanwhile the inhibitor proline stabilizes an X‐shaped conformation, redirecting assembly toward filaments to enable efficient feedback ...
Tianyi Zhang, Qingqing Leng, Siran Li, Huan‐Huan Hu, Ji‐Long Liu   +4 more
wiley   +1 more source

Composite membranes comprising of polymeric and molecular amines embedded in poly(vinyl alcohol) matrices to facilitate CO2/H2 separation

The Canadian Journal of Chemical Engineering, Volume 104, Issue 8, Page 4453-4463, August 2026.
Polymeric and molecular amines embedded in hygroscopic matrices to facilitate CO2 transport for CO2/H2 separation. Abstract This work dealt with composite membranes comprising of polyvinylamine (PVAm) and triethylenetetramine (TETA) embedded in poly(vinyl alcohol) (PVA) for CO2/H2 separation via facilitated transport of CO2, where polymeric and ...
Steve Yijie Hu, Kean Wang, Xianshe Feng
wiley   +1 more source

Research progress on application of guanidinoacetic acid in sheep production

Siliao yanjiu
Guanidinoacetic acid (GAA) is an important precursor of creatine synthesis in vertebrates, and is also a new nutritional feed additive. Due to its good cost performance and bioavailability, as well as its more stable characteristics than creatine ...
ZHANG Jian-sheng, HUANG Xin-yu, NAN Jing-dong, CHEN Guo-wang, HAO Cai-hong, ZHANG Bei, GUO Li-hong, ZHU Yuan-fang   +7 more
doaj  

Cyanobacterial Biofertilizer Production by Guanidine-Producing Enzymes. [PDF]

ACS Synth Biol
Lee H, Sebesta J, Schaedig E, Wu C, Pakrasi HB, Yu J.   +5 more
europepmc   +1 more source

Mechanochemistry as an Emerging Tool for Organofluorine Chemistry

Chemistry–Methods, Volume 6, Issue 8, August 2026.
Fluorinated scaffolds are central across many areas of chemistry, driving the demand for efficient and sustainable synthetic methods. Mechanochemistry has emerged as a powerful alternative to conventional approaches, offering reduced environmental impact, shorter reaction times, and unique reactivity and selectivity.
Marie Caldiero, Nicolas Delcroix, Vitalii Solomin, Thomas Castanheiro   +3 more
wiley   +1 more source

A rapid and accurate guanidine CEST imaging in ischemic stroke using a machine learning approach. [PDF]

Phys Med Biol
Viswanathan M, Yin L, Kurmi Y, Chen Y, Jiang X, Xu J, Afzal A, Zu Z.   +7 more
europepmc   +1 more source