Results 121 to 130 of about 56,931 (242)

Comprehensive Biophysical Profiling Evidences Self‐Oligomerization of Bacterially Expressed Pc Protein

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Polycomb (Pc), a core component of Polycomb Repressive Complex 1 (PRC1), is largely intrinsically disordered yet forms buffer‐ and concentration‐dependent higher‐order assemblies. Integrative biophysical analysis and cryo‐electron microscopy reveal dynamic, heterogeneous oligomers, whereas AlphaFold modeling suggests that structural organization is ...
Maria Zahid, Sabin Prajapati, Ghazaleh Alamdari, Kai Tittmann, Selin Kara   +4 more
wiley   +1 more source

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson, Cerissa C. van Walstijn, Vladyslav Lysenko, Marta A. Wilbrink, David Alencar Araripe, Jeroen M. Punt, Mario van der Stelt, Willem Jespers, Paolo Innocenti, Nathaniel I. Martin   +9 more
wiley   +1 more source

Synthesis of guanidine from ammonium thiocyanate in solid state

Journal of the Brazilian Chemical Society, 2004
Guanidine is an important substance for modern living beings as well as for the prebiotic chemistry. We studied the reaction between ammonium and thiocyanate species in solid state with different substances (river sand, kaolin, transition metals, salts ...
Zaia Dimas A. M., Santana Henrique de, Toppan Rodrigo, Zaia Cássia T. B. V.   +3 more
doaj  

N‐Amidinyl‐Benzodiazaborines as Novel Boron‐Based Scaffolds: Synthesis and Application in Retromer Stabilization

Advanced Synthesis &Catalysis, Volume 368, Issue 11, 3 June 2026.
In this work, we successfully synthesized a library of novel N‐amidinyl‐benzodiazaborines, showing how these heteroaryl guanyl hydrazones are able to stabilize the retromer, a protein complex involved in the disposal of misfolded and aggregated proteins, whose malfunction is observed in multiple neurodegenerative diseases.
Alessandro Dimasi, Arianna Montoli, Michele Buonaguro, Leonardo Maiorana, Giovanni Macetti, Eleonora Colombo, Luca Muzio, Greta Donati, Daniele Passarella, Pierfausto Seneci, Valerio Fasano   +10 more
wiley   +1 more source

Guanidines: Privileged Scaffolds Against Neglected Tropical Diseases: A Review. [PDF]

Pharmaceuticals (Basel)
Dos Anjos LR, de Araújo RSA, Dos Reis MML, Costa NCS, Bernardo VG, Zampieri EH, Rodrigues KADF, Cilli EM, González ERP, Mendonça-Junior FJB.   +9 more
europepmc   +1 more source

Tuning the Photochemistry of Entatic State Model Systems

Zeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 9, 3 June 2026.
We present the photochemistry of the entatic state model [Cu(DMEGqu)2]+/2+, a copper guanidino‐quinoline complex pair. By transient IR and UV/Vis spectroscopy, we obtained the lifetimes of the different excited states. We show that the structural effect of the guanidine tunes the photochemistry of this entatic state model.
Alexander Hoffmann, Julia Stanek, Stefan Hofmann, Michael Rampp, Benjamin Maerz, Benjamin Grimm‐Lebsanft, Melissa Kindler, Tobias Seitz, Michael Rübhausen, Wolfgang Zinth, Sonja Herres‐Pawlis   +10 more
wiley   +1 more source

Validation of Guanidine-EDTA as a Preservative Agent for the Analysis of miRNAs and mRNAs in Blood Samples of Chagas Disease Patients. [PDF]

Pathogens
Faier-Pereira A, Finamore-Araujo P, Brito MMR, Hasslocher-Moreno AM, Moreira OC.   +4 more
europepmc   +1 more source

A Trinuclear Manganese(II) Complex Bridged by a Triaminoguanidine‐Based Schiff Base Ligand: Structure and Magnetic Properties

Zeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 9, 3 June 2026.
A triaminoguanidine‐based Schiff base ligand enables the directed assembly of a trinuclear manganese(II) complex with an almost equilateral triangular topology. Weak antiferromagnetic exchange interactions in combination with axial zero‐field splitting govern the magnetic behavior of the Mn3 core. A triaminoguanidine‐based Schiff base ligand provides a
Daniel Plaul, Helmar Görls, Winfried Plass   +2 more
wiley   +1 more source

Enantioselective organocatalytic radical alkylation enabled by photoexcitation. [PDF]

Chem Sci
Song Y, Wang R, Lu X, Zhou Y, Feng X, Cao W, Liu X.   +6 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, Volume 16, Issue 6, Page 1222-1236, June 2026.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source