Results 121 to 130 of about 57,067 (241)

GUANIDINATED CYTOCHROME C [PDF]

open access: yesProceedings of the National Academy of Sciences, 1964
T P, HETTINGER, H A, HARBURY
openaire   +2 more sources

Comparison of Dried Blood Spot Sampling Methods for RNA‐Based Biomarker Measurement in Anti‐Doping

open access: yesDrug Testing and Analysis, Volume 18, Issue 8, Page 959-966, August 2026.
This study demonstrates that RNA‐based biomarkers of erythropoiesis, ALAS2 and CA1, can be reliably quantified across commonly used DBS sampling matrices, including venous and capillary blood spotted on cellulose cards and the Tasso‐M20 device. ABSTRACT Dried blood spot (DBS) sampling offers logistical advantages, but it remains unexplored whether ...
Jacob Bejder   +9 more
wiley   +1 more source

Enhanced Quantitative Phosphocreatine MR Imaging of Skeletal Muscle Using a Global–Local Two‐Branch Deep Learning Model

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 2, Page 741-755, August 2026.
ABSTRACT Purpose Phosphocreatine (PCr) is an essential marker of muscle metabolism, and accurate quantification of its (fs) and its exchange rate (ksw) is essential for diagnosing various muscular and neuromuscular diseases. Although chemical exchange saturation transfer (CEST) MRI can detect the saturation transfer effect from PCr, quantification of ...
Malvika Viswanathan   +9 more
wiley   +1 more source

Damping amyloid‐associated conformational fluctuations in a protein by an engineered diselenide bridge

open access: yesProtein Science, Volume 35, Issue 8, August 2026.
Abstract Polypeptide cross‐β assembly, characteristic of diverse proteotoxic diseases, defines a general thermodynamic ground state and limits the shelf lives of peptide‐ and protein therapeutics. A model is provided by insulin. Although the hormone contains a predominance of α‐helix, its fibrils exhibit cross‐β reorganization.
Yanwu Yang   +5 more
wiley   +1 more source

Covalent Conjugation of Polyethylenimine to Mesoporous Silica Nanoparticles for Therapeutic Agents Delivery

open access: yesChemistrySelect, Volume 11, Issue 30, 10 August 2026.
A biocompatible method was developed for covalent PEI coating of mesoporous silica nanoparticles (MSNPs) using a chloroform:MeCN (20:80) solvent system instead of conventional DMF. This approach achieved higher PEI conjugation efficiency, confirmed by TGA and FTIR analyses, while maintaining conditions compatible with sensitive biomolecules. The method
Olia Alijanpourtolouti   +3 more
wiley   +1 more source

Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources

open access: yesThe FEBS Journal, Volume 293, Issue 15, Page 4645-4659, August 2026.
This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani   +8 more
wiley   +1 more source

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