Demethylation of methylguanidine by a stepwise dioxygenase and lyase reaction [PDF]
Nature CommunicationsGuanidine-responsive riboswitches control genes that enable either detoxification or assimilation of guanidino compounds. In Vreelandella boliviensis and other halophilic bacteria, genes encoding the guanidine carboxylase pathway are found in a guanidine
Malte Sinn +5 more
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Guanidine-Based Ligands in Bioinorganic Chemistry: Coordination Modes and Applications in Anticancer Metallodrugs [PDF]
Bioinorganic Chemistry and ApplicationsGuanidine-containing molecules represent a versatile class of nitrogen-rich compounds whose unique structural and physicochemical features underpin a rich and tunable coordination chemistry.
Almudena del Campo-Balguerías +3 more
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Modification of the existing maximum residue level for dodine in honey [PDF]
EFSA JournalIn accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Arysta Lifescience Benelux Srl submitted a request to the competent national authority in Spain to modify the existing maximum residue level (MRL) for the active substance dodine ...
European Food Safety Authority (EFSA) +10 more
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Guanidine aptamers are present in vertebrate RNAs associated with calcium signaling and neuromuscular function [PDF]
Nature CommunicationsGuanidine is a protein denaturant that is a widely used constituent in explosives, plastics, and resins. Its effects on muscle contraction were initially reported in 1876, which eventually led to the use of guanidine as a treatment for certain ataxia ...
Kumari Kavita +6 more
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Improvement in heavy metal removal from aqueous solution using polyetherimide nanofiltration membrane modified by coating approach [PDF]
Journal of Applied Research in Water and Wastewater, 2022 This research focused on improving the antifouling properties and rejection performance of polyetherimide (PEI) nanofiltration membrane by chemical surface modification (surface coating).
Madineh Sadeghipour +2 more
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A variant of guanidine-IV riboswitches exhibits evidence of a distinct ligand specificity
RNA Biology, 2023 Riboswitches are regulatory RNAs that specifically bind a small molecule or ion. Like metabolite-binding proteins, riboswitches can evolve new ligand specificities, and some examples of this phenomenon have been validated.
Felina Lenkeit +5 more
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Guanidine-Containing Antifungal Agents against Human-Relevant Fungal Pathogens (2004–2022)—A Review
Journal of Fungi, 2022 The guanidine moiety is typically a highly basic group, and can be found in a wide variety of drugs, such as zanamivir (Relenza) and metformin (Fortamet), as well as in biologically active compounds for numerous disease areas, including central nervous ...
Simon D. P. Baugh
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Synthesis and Biological Evaluation of Amidinourea Derivatives against Herpes Simplex Viruses
Molecules, 2021 Current therapy against herpes simplex viruses (HSV) relies on the use of a few nucleoside antivirals such as acyclovir, famciclovir and valacyclovir. However, the current drugs are ineffective against latent and drug-resistant HSV infections.
Anita Toscani +6 more
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Evaluation of guanidine antifungal solutions for denture base resin: an in vitro study
Revista da Faculdade de Odontologia de Porto Alegre, 2020 Background: The purposes of this study were: (1) to formulate polyhexamethylene guanidine hydrochloride (PHMGH) solutions at different concentrations; (2) to evaluate their antifungal activity against a mature biofilm of Candida albicans on acrylic ...
Maria Eduarda Rodrigues Gama +4 more
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Isopropoxy Benzene Guanidine Kills Staphylococcus aureus Without Detectable Resistance
Frontiers in Microbiology, 2021 Serious infections caused by multidrug-resistant Staphylococcus aureus clearly urge the development of new antimicrobial agents. Drug repositioning has emerged as an alternative approach that enables us to rapidly identify effective drugs.
Xiufeng Zhang +11 more
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