Results 31 to 40 of about 68,963 (231)

Guanidine hydrochloride reactivates an ancient septin hetero-oligomer assembly pathway in budding yeast

eLife, 2020
Septin proteins evolved from ancestral GTPases and co-assemble into hetero-oligomers and cytoskeletal filaments. In Saccharomyces cerevisiae, five septins comprise two species of hetero-octamers, Cdc11/Shs1–Cdc12–Cdc3–Cdc10–Cdc10–Cdc3–Cdc12–Cdc11/Shs1 ...
Courtney R Johnson, Marc G Steingesser, Andrew D Weems, Anum Khan, Amy Gladfelter, Aurélie Bertin, Michael A McMurray   +6 more
doaj   +1 more source

Self-Assembled Lipoplexes of Short Interfering RNA (siRNA) Using Spermine-Based Fatty Acid Amide Guanidines: Effect on Gene Silencing Efficiency

Pharmaceutics, 2011
Four guanidine derivatives of N4,N9-diacylated spermine have been designed, synthesized, and characterized. These guanidine-containing cationic lipids bound siRNA and formed nanoparticles. Two cationic lipids with C18 unsaturated chains, N1,N12-diamidino-
Abdelkader A. Metwally, Ian S. Blagbrough   +1 more
doaj   +1 more source

Sequence-specific RNA cleavage by PNA conjugates of the metal-free artificial ribonuclease tris(2-aminobenzimidazole)

Beilstein Journal of Organic Chemistry, 2015
Tris(2-aminobenzimidazole) conjugates with antisense oligonucleotides are effective site-specific RNA cleavers. Their mechanism of action is independent of metal ions. Here we investigate conjugates with peptide nucleic acids (PNA).
Friederike Danneberg, Alice Ghidini, Plamena Dogandzhiyski, Elisabeth Kalden, Roger Strömberg, Michael W. Göbel   +5 more
doaj   +1 more source

From lab reagent to metabolite: the riboswitch ligand guanidine as a relevant compound in bacterial physiology

Journal of Bacteriology
Efforts of the last 20 years in validating novel riboswitches led to the identification of numerous new motifs recognizing compounds with well-established biological functions.
Payton Bowman, Hubert Salvail
doaj   +1 more source

Asymmetric α-amination of β-keto esters using a guanidine–bisurea bifunctional organocatalyst

Beilstein Journal of Organic Chemistry, 2016
An asymmetric α-amination of β-keto esters with azodicarboxylate in the presence of a guanidine–bisurea bifunctional organocatalyst was investigated. The α-amination products were obtained in up to 99% yield with up to 94% ee.
Minami Odagi, Yoshiharu Yamamoto, Kazuo Nagasawa   +2 more
doaj   +1 more source

Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides

Pharmaceuticals, 2010
The widespread application of cell penetrating agents to clinical therapeutics and imaging agents relies on the ability to prepare them on a large scale and to readily conjugate them to their cargos. Dendritic analogues of cell penetrating peptides, with
Colin V. Bonduelle, Elizabeth R. Gillies
doaj   +1 more source

Guanidine-Functionalized Amphiphilic Silica Nanoparticles as a Pickering Interfacial Catalyst for Biodiesel Production

, 2020
A series of surface-modified SiO2 nanoparticles (NPs) were designed and prepared by combining a guanidine group (1,1,3,3-tetramethylguanidine [TMG]) as the base catalytic functionality and n-alkyl chains as the hydrophobic functionalities.
Wenli Peng (8501007), Baoliang Peng (1723366), Xia Han, Ping Hao (353818), Ping Hao, Honglai Liu, Jianhui Luo, Baoliang Peng, Xia Han (73012), Honglai Liu (1425166), Wenli Peng, Jianhui Luo (1636969)   +11 more
core   +1 more source

Comparative in vitro Antibacterial Activity of Polyhexamethylene Guanidine Hydrochloride and Polyhexamethylene Guanidine Succinate

Антибиотики и Химиотерапия, 2020
Eye infection is one of the temporary invalidity causes that can lead to blindness. The former antibacterial components of eye drops were polyhexamethylene guanidine hydrochloride and polyhexamethylene guanidine phosphate.
Kam An Cha, N. E. Grammatikova, I. A. Vasilenko, S. A. Kedik   +3 more
doaj  

Guanidine-Catalyzed Reductive Amination of Carbon Dioxide with Silanes: Switching between Pathways and Suppressing Catalyst Deactivation

, 2018
A mechanistic investigation into the guanidine-catalyzed reductive amination of CO2, using a combination of 1H, 29Si NMR, FT-IR, MS, and GC profiling, is reported.
José A. Morales-Serna (1313736), Rachel L. Nicholls (5019251), James A. McManus (5019248), Andrew J. P. White (1310940), Bao N. Nguyen (1355568), Christopher M. Rayner (2711371)   +5 more
core   +2 more sources

Demethylation of methylguanidine by a stepwise dioxygenase and lyase reaction

Nature Communications
Guanidine-responsive riboswitches control genes that enable either detoxification or assimilation of guanidino compounds. In Vreelandella boliviensis and other halophilic bacteria, genes encoding the guanidine carboxylase pathway are found in a guanidine
Malte Sinn, Dietmar Funck, Felix Gamer, Clemens Blumenthal, Cecilia Kramp, Jörg S. Hartig   +5 more
doaj   +1 more source