Results 51 to 60 of about 57,067 (241)

A Synthetic Method to Access Symmetric and Non-Symmetric 2-(<em>N</em>,<em>N</em><em>'</em>-disubstituted)guanidinebenzothiazoles

Molecules, 2012
Symmetric and non-symmetric 2-(<em>N</em>-H, <em>N</em>-methyl, <em>N</em>-ethylenyl and <em>N</em>-aryl)guanidinebenzothiazoles were synthesized from the reaction of ammonia, methylamine, pyrrolidine and ...
Efrén V. García-Báez, Alejandro Cruz, Itzia I. Padilla-Martínez   +2 more
doaj   +1 more source

Synthesis, Characterization and Docking Study of Novel Pyrimidine Derivatives as Anticancer Agents

Indonesian Journal of Chemistry, 2020
New compounds 5 and 9 using DNA bases e.g. Adenine 1 and Guanine 6 derivatives have been synthesized. The use of simple methods to synthesize compounds 5 and 9 were done using pyrimidine as an alternative DNA base ring.
Manal Mohamed Talaat El-Saidi, Ahmed Ali El-Sayed, Erik Bjerregaard Pedersen, Mohamed Abdelhamid Tantawy, Nadia Ragab Mohamed, Wafaa Ahmed Gad   +5 more
doaj   +1 more source

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, EarlyView.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Evaluation of Antileishmanial and Antibacterial Activity of Bioconjugate Guanidine–Temporin

Pharmaceuticals
Background: Peptides are promising tools in medicine for viral, bacterial, and parasitic infections. MAP1 and MAP2 are peptides with antimicrobial activity.
Gabriel Antunes Santoro, Natalia Caroline Souza Costa, Sarah Tolentino Rocha Brandão, Jhonatan Santos de Lima, Angela Maria Arenas Velasquez, Luana Ribeiro dos Anjos, Cauã Dias Abrão, João Victor Marcelino de Souza, Marcela Nunes Argentin, Ilana Lopes Baratella da Cunha Camargo, Marcia A. S. Graminha, Eduardo Rene P. Gonzalez, Eduardo Maffud Cilli   +12 more
doaj   +1 more source

Chiral Guanidines

Journal of Synthetic Organic Chemistry, Japan, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ishikawa, Tsutomu, Isobe, Toshio
openaire   +2 more sources

Sequential catalytic nanosystem of carbon dots and uricase integrated with polydopamine for therapy of gouty wound ulceration

BMEMat, EarlyView.
Sequential dual‐catalytic treatment of the gout wound ulceration process by CDs‐Uri@PDA. (a) Synthesis steps and morphology of CDs‐Uri@PDA. (b) Sequential treatment process and mechanism of CDs‐Uri@PDA for gout wound ulceration according to (i) uric acid reduction, (ii) antibacterial activity, and (iii) anti‐inflammatory effects.
Yonglan Yang, Yang Yang, Pengpeng Ma, Ruiqi Zhu, Xia Pan, Shaoling Zheng, Bo Chen, Yanli Jin, Youcong Gong, Jie Liu, Tianwang Li, Xu Chen   +11 more
wiley   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Quantification of guanidine in environmental samples using benzoin derivatization and LC-MS analysis

MethodsX
The recent discovery of guanidine-dependent riboswitches in many microbes raised interest in the biological function and metabolism of this nitrogen-rich compound.
Richard Gruseck, Marton Palatinszky, Michael Wagner, Thilo Hofmann, Michael Zumstein   +4 more
doaj   +1 more source

Exploring 3D-QSAR to identify potential small molecule for treating Alzheimer disease: A case study with b-secretase inhibitors [PDF]

Scripta Medica
Background/Aim: One of the most common neurological conditions that results in dementia is Alzheimer disease. The current treatment options for Alzheimer disease include acetylcholinesterase (AChE) and -methyl-D-aspartate (NMDA) inhibitors, but there is ...
More Uttam A., Patel Maitri, Patel Krishna, Patel Harsiddhi, Patel Kruti Y., Jain Neha, Khan Shabeena, Vasandiya Kinjal, Noolvi Malleshappa N., Palkar Mahesh B.   +9 more
doaj   +1 more source