Results 81 to 90 of about 57,067 (241)

X-ray Structure of Eleven New N,N′-Substituted Guanidines: Effect of Substituents on Tautomer Structure in the Solid State

Crystals
Guanidine-containing molecules are an interesting class of compounds within both medicinal and material sciences. Having knowledge of their tautomerism is key in designing guanidines that interact with biological and chemical receptors.
Vijayaragavan Elumalai, Vaclav Eigner, Nicholas Alexander Janjua, Per-Olof Åstrand, Torkild Visnes, Eirik Sundby, Bård Helge Hoff   +6 more
doaj   +1 more source

Toward Metabolomics Analyses With Combined Capillary Vibrating Sharp-Edge Spray Ionization and Atmospheric Pressure Chemical Ionization. [PDF]

Rapid Commun Mass Spectrom
ABSTRACT Rationale The varied properties of metabolomics components dictate the tools used in mass spectrometry (MS) characterization including the selection of the ionization source. However, the ionization of select compounds limits characterization efficiency.
Pursell M, Ojanuga A, Banerjee C, Ezeigbo E, Rahman M, Dewasurendra VK, Hughart TB, Johnson MB, Sultana MN, Guo X, Alexander G, Patel P, Li P, Legleiter J, Valentine SJ.   +14 more
europepmc   +2 more sources

From the sea to DNA barcode: Optimized preservation method for gelatinous zooplankton integrative taxonomy

Limnology and Oceanography: Methods, EarlyView.
Abstract Assigning taxonomic identity and thus assessing taxonomic diversity in gelatinous zooplankton is challenging due to their fragility and difficult preservation. Formalin fixation compromises DNA integrity, while flash‐freezing, ethanol, and acetone preservation affect morphological features. In this study, we developed a methodological protocol
Claudia Traboni, Rade Garić, Rita Marino, Paolo Sordino, Priscilla Licandro   +4 more
wiley   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

AI/ML Enabled High‐Throughput Design and Synthesis for Energetic Molecules

Materials Genome Engineering Advances, EarlyView.
Novel design methods for a special kind of functional molecules — the energetic molecules—are summarized. Both classic Machine Learning (ML) and Artificial Intelligence (AI) generative models are utilized for the high‐throughput design of these energetic molecules, and a sort of high‐energy low‐sensitivity molecules are obtained.
Wen Qian
wiley   +1 more source

Synergistic Effects of Phenolic Resin and Polymer Architecture on Crosslink Density and Damping in Poly(Epichlorohydrin‐Co‐Ethylene Oxide‐Co‐Allyl Glycidyl Ether) (GECO) Elastomers

Journal of Polymer Science, EarlyView.
Phenolic resin reduces crosslink density and alters the viscoelastic response of GECO elastomers. The magnitude of these changes depends strongly on polymer architecture. Damping performance is governed by the combined effects of network density and molecular structure, not resin content alone, providing a framework for designing advanced vibration ...
Yalçın Yalaki, Murat Şen
wiley   +1 more source

Coordination chemistry of bicyclic\ud guanidines and guanidinates [PDF]

, 2011
A [5:5] ligand based on the bicyclic guanidine 1,4,6-triazabicyclo[3.3.0]oct-4-ene [Htbo] has been synthesised. Two of these tbo units have been linked via a carbon bridgehead to form a novel bidentate ligand. Based on the knowledge that the electronic properties and specific steric interactions at a metal can lead to new insights into the relationship
openaire   +1 more source

Structural and Stability Analysis of de Novo Designed Proteins Incorporating a Plant Self‐Incompatibility Motif

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Artificial protein design enables the creation of stable scaffolds beyond those evolved in nature. Incorporation of native functional motifs into de novo scaffolds provides a promising strategy to mimic natural interactions while altering structural frameworks.
Hakuto Miyoshi, Koya Sakuma, Yoshitaka Moriwaki, Naoki Aoyama, Toma Kashima, Tohru Terada, Akimasa Miyanaga, Shinya Fushinobu   +7 more
wiley   +1 more source

Synthalin, Buformin, Phenformin, and Metformin: A Century of Intestinal “Glucose Excretion” as Oral Antidiabetic Strategy in Overweight/Obese Patients

Livers
After the first release of synthalin B (dodecamethylenbiguanide) in 1928 and its later retraction in the 1940s in Germany, the retraction of phenformin (N-Phenethylbiguanide) and of Buformin in the USA (but not outside) because of the lethal complication
Giuliano Pasquale Ramadori
doaj   +1 more source