Results 81 to 90 of about 56,931 (242)
Optimized iCIEF Fractionation Enables Deep Profiling of Antibody Drug Conjugate Charge Heterogeneity
ELECTROPHORESIS, EarlyView.This study developed and optimized an iCIEF fractionation method to characterize ADC charge variants. The optimized approach enabled stable separation, identification of major PTMs, and drug‐load distributions across light and heavy chains. ABSTRACT Antibody drug conjugates (ADCs) are a novel class of therapeutic drugs that combine selectivity of an ...
Eunju Jang +2 more
wiley +1 more source
Ligand response of guanidine-IV riboswitch at single-molecule level
eLifeRiboswitches represent a class of non-coding RNA that possess the unique ability to specifically bind ligands and, in response, regulate gene expression.
Lingzhi Gao, Dian Chen, Yu Liu
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Proteomic signatures of equine dental tooth tissues in ageing and disease
Equine Veterinary Journal, EarlyView.Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen +8 more
wiley +1 more source
MicroorganismsThe objective of this study was to compare, by qPCR, the circulating blood parasite load of Trypanosoma cruzi in the buffy coat, and in whole blood mixed with boiled and unboiled guanidine hydrochloride-EDTA buffer, of individuals with chronic ChD.
Daniela Liempi +6 more
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Exploration, EarlyView.Nanofluidic biosensors employing in‐plane, out‐of‐plane, and free‐plane architectures transduce biomolecular information into fluidic signals through nanoscale manipulation of confined fluids, offering a quantitative and highly sensitive platform for biochemical detection. ABSTRACT Nanofluidics, the study of fluid transport confined within nanochannels
Qun Ma, Yan Xu
wiley +1 more source
Neue Guanidin ‐ Abkömmlinge [PDF]
Berichte der deutschen chemischen Gesellschaft, 1870 n ...
openaire +2 more sources
Food Safety and Health, EarlyView.This review elucidates the formation pathways and detection technologies for ethyl carbamate, biogenic amines, and higher alcohols in Huangjiu. It concludes that integrated control frameworks are essential to decouple safety risks from the metabolic processes responsible for flavor development.
Lulu Liu +5 more
wiley +1 more source
Molecules, 2019 Antimicrobial resistance has been seriously threatening human health, and discovering new antimicrobial agents from the natural resource is still an important pathway among various strategies to prevent resistance.
Xiaoyuan Song +3 more
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Microscopy Research and Technique, EarlyView.Assessment of Restoring Chemically Damaged Hair Fibers Using Microscopy and Spectroscopy. ABSTRACT This paper analyses hair restoration products currently on the market that treat chemically processed hair. This study measured the restoration of structural integrity in hair samples from both chemically damaged hair (chemically relaxed, bleached, and ...
L. P. A. Mauricio +2 more
wiley +1 more source
Coordination chemistry of bicyclic\ud guanidines and guanidinates [PDF]
, 2011 A [5:5] ligand based on the bicyclic guanidine 1,4,6-triazabicyclo[3.3.0]oct-4-ene [Htbo] has been synthesised. Two of these tbo units have been linked via a carbon bridgehead to form a novel bidentate ligand. Based on the knowledge that the electronic properties and specific steric interactions at a metal can lead to new insights into the relationship
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