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Oxidant-Antioxidant Capacity of Dietary Guanidinoacetic Acid
Annals of Nutrition and Metabolism, 2015<b><i>Background/Aims:</i></b> Guanidinoacetic acid (GAA) is an experimental nutritional additive under the functional group amino acids and derivatives, yet its use in human nutrition is hindered by limited data on GAA safety. In this double blind, placebo-controlled pilot study, we evaluated the effects of dietary GAA (3 g/day)
Sergej M. Ostojic +2 more
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A new enzymatic assay of urinary guanidinoacetic acid
Clinica Chimica Acta, 1991We describe a new enzymatic determination of urinary guanidinoacetic acid (GAA) with guanidinoacetate kinase (ATP: guanidinoacetate N-phosphotransferase, EC 2.7.3.1), which does not require a blank to correct for endogenous constituents (ADP and pyruvate).
Y, Shirokane, M, Nakajima, K, Mizusawa
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Advanced physiological roles of guanidinoacetic acid
European Journal of Nutrition, 2015Dietary guanidinoacetic acid (GAA) seems to improve cellular bioenergetics by stimulating creatine biosynthesis. However, GAA could have other biological functions that might affect its possible use as a food ingredient in human nutrition. In this paper, we identified several alternative physiological roles of supplemental GAA, including the ...
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Guanidinoacetic acid as a performance-enhancing agent
Amino Acids, 2015Guanidinoacetic acid (GAA; also known as glycocyamine or guanidinoacetate) is the natural precursor of creatine, and under investigation as a novel dietary agent. It was first identified as a natural compound in humans ~80 years ago. In the 1950s, GAA's use as a therapeutic agent was explored, showing that supplemental GAA improved patient-reported ...
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Tackling guanidinoacetic acid for advanced cellular bioenergetics
Nutrition, 2017Tissues with high-energy output, such as the brain and skeletal muscle, suffer the most from impaired or depleted energy levels, with innovative nutritional approaches needed to effectively tackle metabolic deficits in bioenergetics. Here, we highlight the role of guanidinoacetic acid in the control and provision of cellular energy by its interaction ...
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Cataloguing guanidinoacetic acid content in various foods
International Journal for Vitamin and Nutrition Research, 2022Abstract. Guanidinoacetic acid (GAA) is a natural amino acid derivative involved in several metabolic pathways across the human body, including creatine biosynthesis, arginine utilization, and neuromodulation. Apart from GAA synthesized internally from glycine and arginine, a total daily exposure to GAA also involves exogenous dietary sources. However,
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Guanidinoacetic acid loading affects plasma γ-aminobutyric acid in healthy men
European Journal of Nutrition, 2015Guanidinoacetic acid (GAA), a precursor of creatine and an innovative dietary agent, activates γ-amino butyric acid (GABA) receptors yet clinical effects of dietary GAA on GABA metabolism are currently unknown. The main aim of this pilot research was to investigate whether GAA loading affected peripheral GABA homeostasis in healthy humans.Eight healthy
Sergej M, Ostojic, Marko, Stojanovic
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Guanidinoacetic acid loading for improved location-specific brain creatine
Clinical Nutrition, 2021We conducted here a secondary analysis of previously completed guanidinoacetic acid (GAA) loading trials categorizing participants into responders and non-responders using cut-off points for an increase in the location-specific levels of brain creatine (e.g.
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Guanidinoacetic acid as a feed supplement for poultry
World's Poultry Science Journal, 2020Guanidinoacetic acid (GAA) is immediate substrate for biosynthesis of creatine (CREA). The phosphorylated form of CREA serves as a rapidly mobilisable reserve of high-energy phosphates in skeletal ...
F. Khajali +2 more
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Human gut microbiota as a source of guanidinoacetic acid
Medical Hypotheses, 2020Guanidinoacetic acid (GAA) is a natural amino acid derivative that acts as a precursor of creatine while being synthesized and utilized in a two-step reaction that takes place in the human kidney and liver. In this paper, we have proposed that guanidinoacetase, an enzyme present in healthy gut microbiota, might contribute to gross GAA turnover by ...
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