Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons +17 more
wiley +1 more source
Ligand specificity and adaptability revealed by the first Guanine-II riboswitch tertiary structure. [PDF]
Li H +6 more
europepmc +1 more source
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert +5 more
wiley +1 more source
Sequence-specific fluorescence turn-on arises from base pairing-templated tautomerism in the tricyclic cytidine analogue <sup>DEA</sup>tC. [PDF]
Shalamberidze A +3 more
europepmc +1 more source
Dual Interaction of ADP Ribosylation Factor 1 with Sec7 Domain and with Lipid Membranes during Catalysis of Guanine Nucleotide Exchange [PDF]
Sophie Béraud-Dufour +3 more
openalex +1 more source
The Influence of the Capping Step During Solid-Phase Phosphoramidite Synthesis of Oligonucleotides on Synthetic Errors in Oligonucleotides. [PDF]
Yakovleva KI +7 more
europepmc +1 more source
Substrate inhibition in a human variant of hypoxanthine-guanine phosphoribosyltransferase.
Lafras M. Steyn, Eric H. Harley
openalex +1 more source
SPECTRAL ANALYSIS OF GUANINE AND CYTOSINE FLUCTUATIONS OF MOUSE GENOMIC DNA [PDF]
WENTIAN LI, DIRK HOLSTE
openalex +1 more source
Solid-Phase Synthesis of Guanine Derivatives with Four Diversity Elements via AgNO<sub>3</sub>‑Mediated Guanidine Formation. [PDF]
Moon J, Lee J, Lee H, Yoon G, Lee T.
europepmc +1 more source

