Results 201 to 210 of about 201,610 (282)

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

Journal of Biological Chemistry, 1984
P. Sternweis, J. Robishaw
semanticscholar   +1 more source

Nanomaterial‐Enhanced Electrochemical Sensors for Clinical Monitoring of Acyclovir: Integration Into Molecular Diagnostics

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic illustration of biosensor technology for detection of ACV. ABSTRACT Objective This study investigates the innovative application of nanomaterial‐based micro‐devices aimed at enhancing the diagnosis and management of acyclovir (ACV) for herpes virus infections, specifically those caused by HSV‐1, HSV‐2, CMV, and VZV.
Mohammad Darvishi, Mohammad Mahdi Heidari, Reza Kheradmand, Nava Moghadasian Niaki, Mahsa Tabean, Ahmad Mobed   +5 more
wiley   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Uncovering the Role of DNA Repair Impairment in UVA‐Induced Mutagenesis in Human Xeroderma Pigmentosum Variant Cells

Molecular Carcinogenesis, EarlyView.
ABSTRACT Ultraviolet A (UVA) radiation induces DNA damage both directly, by forming cyclobutane pyrimidine dimers (CPDs), and indirectly, by generating oxidative stress. Cells rely on nucleotide excision repair (NER) and translesion synthesis (TLS) to tolerate these lesions.
Camila Corradi, Natália Cestari Moreno, Nathalia Quintero‐Ruiz, Giovana da Silva Leandro, Marcela Teatin Latancia, Tiago Antonio de Souza, Veridiana Munford, Carlos Frederico Martins Menck   +7 more
wiley   +1 more source

Interaction of cisplatin with adenine and guanine: a combined IRMPD, MS/MS, and theoretical study.

Journal of the American Chemical Society, 2013
B. Chiavarino, M. Crestoni, S. Fornarini, D. Scuderi, J. Salpin   +4 more
semanticscholar   +1 more source

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abundantly expressed in MSNs, is a promising biomarker of striatal integrity, but region‐specific associations and its potential for early‐stage ...
Mena Farag, Michael J. Murphy, Nicola Z. Hobbs, Michela Leocadi, Kate Fayer, Olivia Thackeray, Johan Gobom, Marc Ciosi, Amanda Heslegrave, Henrik Zetterberg, Douglas R. Langbehn, Darren G. Monckton, Edward J. Wild, Sarah J. Tabrizi, Rachael I. Scahill   +14 more
wiley   +1 more source

Interplay Between Sex and Cytosine‐Adenine‐Guanine‐Age Product Score in Huntington's Disease: Clinical and Neuroimaging Perspectives

Movement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a cytosine‐adenine‐guanine (CAG) repeat expansion in the huntingtin gene. The disease exhibits sex‐related differences in symptomatology and disease progression, but the effect on brain structural biomarkers and the interaction between sex and CAG‐age ...
Jingwen Yao, Grayson Feng, Guowen Shao, Zexi Wang, Adys Mendizabal, Donatello Telesca, Kaiying Fang, Lola Ibragimova, Juwairia Shoaib, Melanie A. Morrison, Janine M. Lupo   +10 more
wiley   +1 more source

Systematic Review with Meta‐Analysis of Biofluid Markers for Huntington's Disease

Movement Disorders, EarlyView.
Eight Huntington's Disease Biofluid Markers show Meta‐Analytic Significance Across HD‐ISS Stages. Meta‐analyses were conducted for two types of biomarkers: Different from demographically‐matched healthy controls and *Showing change over time. Abstract Primary therapeutic objectives for Huntington's disease (HD) necessitate continued therapy for a long ...
Jane S. Paulsen, Natalie A. Bovin, Jordan D. Clemsen, Alexander Weiss, Abigail M. Key, Monica L. Janz, Alex Pinto, Deven K. Burks, Henrik Zetterberg, Kathleen M. Shannon   +9 more
wiley   +1 more source

Folic Acid Reduces Insulin Resistance in Mice With Diet‐Induced Obesity by Altering One‐Carbon Metabolism and DNA Methylation Patterns of Hypothalamic and Hepatic Insulin Receptor Gene

Molecular Nutrition &Food Research, EarlyView.
Folic acid (FA), a methyl donor in one‐carbon (1C) metabolism, is essential for gene methylation and expression and reported to reduce insulin resistance (IR). However, whether reduced IR is mediated by insulin receptor (InsR) gene methylation is unknown.
Eva Kranenburg, Ruslan Kubant, Clara E. Cho, Zeyu Yang, Mahaylia Datars, Jianzhang Dong, G. Harvey Anderson   +6 more
wiley   +1 more source

Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

Proceedings of the National Academy of Sciences of the United States of America, 2003
Jongdae Lee, T. Chuang, V. Redecke, Liping She, P. Pitha, D. Carson, E. Raz, H. Cottam   +7 more
semanticscholar   +1 more source