Results 211 to 220 of about 283,665 (235)

Metabolism of Guanine and Guanine Nucleotides in Primary Rat Cardiomyocyte Cultures

Biochemical and Molecular Medicine, 1991
The metabolic fate of labeled guanine and of prelabeled guanine nucleotides (GuRN) was studied in cultured rat cardiomyocytes. Special attention was given to guanine salvage in comparison to degradation; to the contribution of GuRN to adenine nucleotides (AdRN); to the fluxes from GMP to IMP and from IMP to GMP; and to the degradation pathways of GuRN.
Esther Zoref-Shani, Oded Sperling, Yaul Bromberg, Yachezkel Sidi, Chaim Shirin   +4 more
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Electronic Excitations in Guanine Quadruplexes [PDF]

, 2014
Guanine rich DNA strands, such as those encountered at the extremities of human chromosomes, have the ability to form four-stranded structures (G-quadruplexes) whose building blocks are guanine tetrads. G-quadruplex structures are intensively studied in respect of their biological role, as targets for anticancer therapy and, more recently, of their ...
Changenet-Barret, P., Hua, Y., Markovitsi, D.   +2 more
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Improved selectivity for the binding of naphthyridine dimer to guanine–guanine mismatch

Bioorganic & Medicinal Chemistry, 2001
Naphthyridine dimer composed of two 2-amino-1,8-naphthyridines and a connecting linker strongly binds to guanine-guanine (G-G) mismatch in duplex DNA. In order to improve G-G selectivity for the binding, we have examined structure modification of the linker.
Nakatani, K, Sando, S, Saito, I
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Metabolism of Guanine and Guanine Nucleotides in Primary Rat Neuronal Cultures

Journal of Neurochemistry, 1992
Abstract: The metabolic fate of guanine and of guanine ribonucleotides (GuRNs) in cultured rat neurons was studied using labeled guanine. 8‐Aminoguanosine (8‐AGuo), an inhibitor of purine nucleoside phosphorylase, was used to clarify the pathways of GMP degradation, and mycophenolic acid, an inhibitor of IMP dehydrogenase, was used to assess the flux ...
S. Brosh, Esther Dantziger, Yechezkel Sidi, Oded Sperling   +3 more
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Radical–Radical Interactions among Oxidized Guanine Bases Including Guanine Radical Cation and Dehydrogenated Guanine Radicals

The Journal of Physical Chemistry B, 2013
We present here a theoretical investigation of the structural and electronic properties of di-ionized GG base pairs (G(•+)G(•+),G(-H1)(•)G(•+), and G(-H1)(•)G(-H1)(•)) consisting of the guanine cation radical (G(•+)) and/or dehydrogenated guanine radical (G(-H1)(•)) using density functional theory calculations. Different coupling modes (Watson-Crick/WC,
Hongfang Yang, Meng Zhang, Mei Wang, Ping Liu, Jing Zhao, Yuxiang Bu   +5 more
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Phylogenetic Analysis and Molecular Evolution of Guanine Deaminases: From Guanine to Dendrites

Journal of Molecular Evolution, 2009
Guanine deaminase (GDA; guanase) is a ubiquitous enzyme that catalyzes the first step of purine metabolism by hydrolytic deamination of guanine, resulting in the production of xanthine. This hydrolase subfamily member plays an essential role in maintaining homeostasis of cellular triphosphate nucleotides for energy, signal transduction pathways, and ...
José R. Fernández, José R. Fernández, Bonnie L. Firestein, Bruce Byrne   +3 more
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Reactivity of mitomycin C with synthetic polyribonucleotides containing guanine or guanine analogs

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1982
The guanine residues in nucleic acids are believed to be the major covalent binding site of the antibiotic mitomycin C. To identify the specific functional group in guanine which reacts with mitomycin C, reactions were run between the antibiotic and poly(G) analogs in which guanine was blocked at the N-7 or O-6 position, or lacked the 2-amino group ...
Janet Weaver, Maria Tomasz
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Structure of Guanine Hydrochloride Dihydrate [PDF]

Nature, 1963
IN the structure determination of deoxyribonucleic acid (DNA), the method of molecular model building must be combined with that of X-ray diffraction because of the overlap and weakness of the small spacing spots on the DNA X-ray diffraction pattern1,2. For this reason, accurate knowledge of the component parts of the DNA molecule is necessary.
John Iball, H. R. Wilson
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[10] Guanine quartet structures

1992
Publisher Summary Of the five nucleosides commonly found in DNA and RNA, only guanosine is capable of forming extensive self-structures in solution, hydrogen bonding with itself to give G–G base pairs, and guanine quartets. The formation of these structures was found to be uniquely dependent on monovalent cations and on the identity of the cation ...
Dipankar Sen, Walter Gilbert
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ChemInform Abstract: PENTAAMMINERUTHENIUM-GUANINE COMPLEXES

Chemischer Informationsdienst, 1974
The synthesis of several pentaammineruthenium(I1 and 111)-guanine complexes is reported, in which the metal is believed to be bound to Ni. The Ru(II1) compounds exhibit a broad low energy guanine-to-metal chargetransfer absorption, while the Ru(1I) complexes show a metal-to-ligand charge transfer in the ultraviolet.
Mike Clarke, Henry Taube
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