Results 231 to 240 of about 201,610 (282)

Can Amplicon Sequencing Be Replaced by Metagenomics for Biodiversity Inventories?

open access: yes
Molecular Ecology Resources, EarlyView.
Lucas Elliott, Eric Coissac
wiley   +1 more source

Base editing platform to investigate pathogenic SAMD9 mutations in paediatric myelodysplastic syndromes

open access: yes
British Journal of Haematology, EarlyView.
Gabriele Canciani   +9 more
wiley   +1 more source
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Bioinspired Crystallization of Guanine

The Journal of Physical Chemistry Letters, 2021
Biological guanine crystals in organisms exhibit excellent optical properties and functions, including broad-band and narrow-band reflectors, band-tunable reflectors, mirrors, and stimuli-responsive structural colors, attributed to the high refractive index of guanine (1.85) and the exquisite control of the polymorphs, morphologies, sizes, exposed ...
Fenghua Chen   +3 more
openaire   +2 more sources

Microhydration of the Guanine−Guanine and Guanine−Cytosine Base Pairs

The Journal of Physical Chemistry A, 2010
Monohydration structures of the guanine-guanine and guanine-cytosine base pairs have been elucidated by IR-UV double resonance spectroscopy combined with ab initio calculations. The systems studied consist of the homodimer of 9-methylguanine and the heterodimer of 9-methylguanine and 1-methylcytosine in which the methyl group is introduced to mimic the
Masashi Ohba   +3 more
openaire   +3 more sources

Conserved guanine-guanine stacking in tetraplex and duplex DNA

European Biophysics Journal, 2001
Using a series of suitably chosen oligonucleotides, we demonstrate that the DNA duplex of d(CCCCGGGG) provides an almost identical CD spectrum as the parallel-stranded tetraplex of d(GGGG). The CD spectra are very sensitive to base stacking in DNA so that the above observation indicates that guanine-guanine stacking is essentially the same within the ...
Jaroslav Kypr   +4 more
openaire   +3 more sources

Electronic Excitations in Guanine Quadruplexes [PDF]

open access: possible, 2014
Guanine rich DNA strands, such as those encountered at the extremities of human chromosomes, have the ability to form four-stranded structures (G-quadruplexes) whose building blocks are guanine tetrads. G-quadruplex structures are intensively studied in respect of their biological role, as targets for anticancer therapy and, more recently, of their ...
Changenet-Barret, P.   +2 more
openaire   +2 more sources

Metabolism of Guanine and Guanine Nucleotides in Primary Rat Cardiomyocyte Cultures

Biochemical and Molecular Medicine, 1991
The metabolic fate of labeled guanine and of prelabeled guanine nucleotides (GuRN) was studied in cultured rat cardiomyocytes. Special attention was given to guanine salvage in comparison to degradation; to the contribution of GuRN to adenine nucleotides (AdRN); to the fluxes from GMP to IMP and from IMP to GMP; and to the degradation pathways of GuRN.
Esther Zoref-Shani   +4 more
openaire   +4 more sources

Improved selectivity for the binding of naphthyridine dimer to guanine–guanine mismatch

Bioorganic & Medicinal Chemistry, 2001
Naphthyridine dimer composed of two 2-amino-1,8-naphthyridines and a connecting linker strongly binds to guanine-guanine (G-G) mismatch in duplex DNA. In order to improve G-G selectivity for the binding, we have examined structure modification of the linker.
Nakatani, K, Sando, S, Saito, I
openaire   +3 more sources

Metabolism of Guanine and Guanine Nucleotides in Primary Rat Neuronal Cultures

Journal of Neurochemistry, 1992
Abstract: The metabolic fate of guanine and of guanine ribonucleotides (GuRNs) in cultured rat neurons was studied using labeled guanine. 8‐Aminoguanosine (8‐AGuo), an inhibitor of purine nucleoside phosphorylase, was used to clarify the pathways of GMP degradation, and mycophenolic acid, an inhibitor of IMP dehydrogenase, was used to assess the flux ...
S. Brosh   +3 more
openaire   +3 more sources

Radical–Radical Interactions among Oxidized Guanine Bases Including Guanine Radical Cation and Dehydrogenated Guanine Radicals

The Journal of Physical Chemistry B, 2013
We present here a theoretical investigation of the structural and electronic properties of di-ionized GG base pairs (G(•+)G(•+),G(-H1)(•)G(•+), and G(-H1)(•)G(-H1)(•)) consisting of the guanine cation radical (G(•+)) and/or dehydrogenated guanine radical (G(-H1)(•)) using density functional theory calculations. Different coupling modes (Watson-Crick/WC,
Hongfang Yang   +5 more
openaire   +3 more sources

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