Results 251 to 260 of about 191,107 (300)

Microhydration of the Guanine−Guanine and Guanine−Cytosine Base Pairs

The Journal of Physical Chemistry A, 2010
Monohydration structures of the guanine-guanine and guanine-cytosine base pairs have been elucidated by IR-UV double resonance spectroscopy combined with ab initio calculations. The systems studied consist of the homodimer of 9-methylguanine and the heterodimer of 9-methylguanine and 1-methylcytosine in which the methyl group is introduced to mimic the
Shu-Hei, Urashima, Hiroya, Asami, Masashi, Ohba, Hiroyuki, Saigusa   +3 more
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Conserved guanine-guanine stacking in tetraplex and duplex DNA

European Biophysics Journal, 2001
Using a series of suitably chosen oligonucleotides, we demonstrate that the DNA duplex of d(CCCCGGGG) provides an almost identical CD spectrum as the parallel-stranded tetraplex of d(GGGG). The CD spectra are very sensitive to base stacking in DNA so that the above observation indicates that guanine-guanine stacking is essentially the same within the ...
J, Kypr, M, Fialová, J, Chládková, M, Tůmová, M, Vorlícková   +4 more
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Improved selectivity for the binding of naphthyridine dimer to guanine–guanine mismatch

Bioorganic & Medicinal Chemistry, 2001
Naphthyridine dimer composed of two 2-amino-1,8-naphthyridines and a connecting linker strongly binds to guanine-guanine (G-G) mismatch in duplex DNA. In order to improve G-G selectivity for the binding, we have examined structure modification of the linker.
Nakatani, K, Sando, S, Saito, I
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Metabolism of Guanine and Guanine Nucleotides in Primary Rat Cardiomyocyte Cultures

Biochemical and Molecular Medicine, 1995
The metabolic fate of labeled guanine and of prelabeled guanine nucleotides (GuRN) was studied in cultured rat cardiomyocytes. Special attention was given to guanine salvage in comparison to degradation; to the contribution of GuRN to adenine nucleotides (AdRN); to the fluxes from GMP to IMP and from IMP to GMP; and to the degradation pathways of GuRN.
E, Zoref-Shani, C, Shirin, Y, Sidi, Y, Bromberg, O, Sperling   +4 more
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Metabolism of Guanine and Guanine Nucleotides in Primary Rat Neuronal Cultures

Journal of Neurochemistry, 1992
Abstract: The metabolic fate of guanine and of guanine ribonucleotides (GuRNs) in cultured rat neurons was studied using labeled guanine. 8‐Aminoguanosine (8‐AGuo), an inhibitor of purine nucleoside phosphorylase, was used to clarify the pathways of GMP degradation, and mycophenolic acid, an inhibitor of IMP dehydrogenase, was used to assess the flux ...
S, Brosh, O, Sperling, E, Dantziger, Y, Sidi   +3 more
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Guanine Uptake by Human Erythrocytes

1991
It has been clearly established that mature human erythrocytes cannot synthesize de novo purines (1); consequently the turnover of purine nucleotides in red cells must result from the continual entry and release of purines. Hypoxanthine and adenine uptake by human erythrocytes has been studied in our laboratories (2–4).
SPOTO, Giuseppe, QUARATINO CP, GIACOMELLO A.   +2 more
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Radical–Radical Interactions among Oxidized Guanine Bases Including Guanine Radical Cation and Dehydrogenated Guanine Radicals

The Journal of Physical Chemistry B, 2013
We present here a theoretical investigation of the structural and electronic properties of di-ionized GG base pairs (G(•+)G(•+),G(-H1)(•)G(•+), and G(-H1)(•)G(-H1)(•)) consisting of the guanine cation radical (G(•+)) and/or dehydrogenated guanine radical (G(-H1)(•)) using density functional theory calculations. Different coupling modes (Watson-Crick/WC,
Jing, Zhao, Mei, Wang, Hongfang, Yang, Meng, Zhang, Ping, Liu, Yuxiang, Bu   +5 more
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Phylogenetic Analysis and Molecular Evolution of Guanine Deaminases: From Guanine to Dendrites

Journal of Molecular Evolution, 2009
Guanine deaminase (GDA; guanase) is a ubiquitous enzyme that catalyzes the first step of purine metabolism by hydrolytic deamination of guanine, resulting in the production of xanthine. This hydrolase subfamily member plays an essential role in maintaining homeostasis of cellular triphosphate nucleotides for energy, signal transduction pathways, and ...
José R, Fernández, Bruce, Byrne, Bonnie L, Firestein   +2 more
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A-like guanine-guanine stacking in the aqueous DNA duplex of d(GGGGCCCC)

Journal of Molecular Biology, 2001
We have used CD spectroscopy, NMR spectroscopy and unrestrained molecular dynamics to study conformational properties of a DNA duplex formed by the self-complementary octamer d(GGGGCCCC). Its unusual CD spectrum contains features indicating A-like stacking of half of the bases, whereas the other half stack in a B-like fashion.
R, Stefl, L, Trantírek, M, Vorlícková, J, Koca, V, Sklenár, J, Kypr   +5 more
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Photodynamic degradation of guanine

Biochemical and Biophysical Research Communications, 1964
J S, Sussenbach, W, Berends
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