Results 151 to 160 of about 93,566 (291)

Loss of E3 ligase HvST1 function substantially increases distal crossover frequency

New Phytologist, Volume 249, Issue 3, Page 1325-1341, February 2026.
Summary This study characterizes the function of a grass‐specific E3 ubiquitin ligase, HvST1, in regulating synapsis and crossover (CO) formation during meiosis in barley (Hordeum vulgare). In large‐genome cereals, COs are predominantly restricted to distal chromosomal regions, limiting genetic recombination and breeding flexibility.
Jamie Neil Orr, Sybille Ursula Mittmann, Luke Ramsay, Dominika Lewandowska, Abdellah Barakate, Malcolm Macaulay, Nicola McCallum, Robbie Waugh, Isabelle Colas   +8 more
wiley   +1 more source

Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms. [PDF]

Cell Commun Signal, 2023
Rodríguez-Blázquez A, Carabias A, Morán-Vaquero A, de Cima S, Luque-Ortega JR, Alfonso C, Schuck P, Manso JA, Macedo-Ribeiro S, Guerrero C, de Pereda JM.   +10 more
europepmc   +1 more source

Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF‐2B subunits revealed by analysis of conserved sequence motifs [PDF]

, 1995
Eugene V. Koonin
openalex   +1 more source

Manipulation of the Unfolded Protein Response by Intracellular Bacterial Pathogens: Mechanisms of ER Hijacking and Therapeutic Implications

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This review illustrates how intracellular bacterial pathogens—such as Brucella, Mycobacterium tuberculosis, and Legionella—secrete effector proteins that specifically target the IRE1α, PERK, and ATF6 branches of the unfolded protein response (UPR) to hijack ER stress signaling.
Enhui Dai, Dongjie Sun, Yanxiao Zhao, Mengtao Zhang, Yifan Wu, Jiabo Ding   +5 more
wiley   +1 more source

The guanine nucleotide exchange factor Vav3 intervenes in the migration pathway of oligodendrocyte precursor cells on tenascin-C. [PDF]

Front Cell Dev Biol, 2022
Schäfer I, Bauch J, Wegrzyn D, Roll L, van Leeuwen S, Jarocki A, Faissner A.   +6 more
europepmc   +1 more source

Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor [PDF]

, 2016
Lydia Chávez‐Vargas, Sendi Rafael Adame‐García, Rodolfo Daniel Cervantes‐Villagrana, Alejandro Castillo‐Kauil, Jessica Bruystens, Shigetomo Fukuhara, Susan S. Taylor, Naoki Mochizuki, Guadalupe Reyes‐Cruz, José Vázquez‐Prado   +9 more
openalex   +1 more source

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source

Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes. [PDF]

Cells, 2022
Nishikawa M, Ito H, Tabata H, Ueda H, Nagata KI.   +4 more
europepmc   +1 more source

SH3‐class Ras guanine nucleotide exchange factors are essential forAspergillus fumigatusinvasive growth [PDF]

, 2019
Adela Martín‐Vicente, Ana Camila Oliveira Souza, Qusai Al Abdallah, Wenbo Ge, Jarrod R. Fortwendel   +4 more
openalex   +1 more source

EFA6A, a guanine nucleotide exchange factor for Arf6, regulates developmental stage-dependent spine morphogenesis, synaptic plasticity, and long-term memory in the hippocampus [PDF]

Takeyuki Sugawara, Hideki Matsuura, Ryo Inagaki, Taïchi Kawamura, Manabu Tanaka, Yoshinobu Hara, Koji Saito, Masahiro Fukaya, Shigeki Moriguchi, Hiroyuki Sakagami   +9 more
openalex   +1 more source