Results 241 to 250 of about 93,566 (291)

Expression of Rho Guanine Nucleotide Exchange Factor 39 (ARHGEF39) and Its Prognostic Significance in Hepatocellular Carcinoma. [PDF]

Med Sci Monit, 2019
Gao J, Jia WD.
europepmc   +1 more source

RAPGEF1 (Rap guanine nucleotide exchange factor (GEF) 1)

, 2011
Aditi Mitra, Vegesna Radha
openalex   +2 more sources

ARF-GEP100, a guanine nucleotide-exchange protein for ADP-ribosylation factor 6, involved in the apoptotic cell death of phagocytes

, 2006
Akimasa Someya, Joel Moss, Martha Vaughan, Isao Nagaoka   +3 more
openalex   +2 more sources

Overexpression of GEFT, a Rho family guanine nucleotide exchange factor, predicts poor prognosis in patients with rhabdomyosarcoma.

, 2014
Chao Sun, Chunxia Liu, Shugang Li, Hong-an Li, Yuanyuan Wang, Yuwen Xie, Bingcheng Li, Xiaobin Cui, Yunzhao Chen, Wenjie Zhang, Feng Li   +10 more
openalex   +1 more source

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The guanine nucleotide-exchange factor, eIF-2B

Biochimie, 1994
Eukaryotic initiation factor eIF-2B catalyses the exchange of guanine nucleotides on another translation initiation factor, eIF-2, which itself mediates the binding of the initiator Met-tRNA to the 40S ribosomal subunit during translation initiation. eIF-2B promotes the release of GDP from inactive [eIF-2.GDP] complexes, thus allowing formation of the ...
N, Price, C, Proud
openaire   +2 more sources

Dbl family guanine nucleotide exchange factors

Trends in Biochemical Sciences, 2001
The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals leading to the activation of Rho GTPases. The tandem Dbl-homology and pleckstrin-homology domains shared by all members of this family represent the structural module responsible for catalyzing the GDP-GTP exchange reaction ...
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A Small Molecule-Regulated Guanine Nucleotide Exchange Factor

Journal of the American Chemical Society, 2009
Selective, pharmacological agents are attractive tools for studying signal transduction because they allow rapid, reversible, and dose-dependent control over intracellular protein function. However, for many targets the identification of potent and selective small molecule agonists and antagonists is a formidable challenge.
Inna, Goreshnik, Dustin J, Maly
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Guanine nucleotide exchange factors: Activators of Ras superfamily proteins

Molecular Reproduction and Development, 1995
AbstractMembers of the Ras superfamily of proteins function as regulated GDP/GTP switches that cycle between active GTP‐complexed and inactive GDP‐complexed states. Guanine nucleotide exchange factors (GEFs) stimulate formation of the GTP‐bound state, whereas GTPase activating proteins (GAPs) catalyze the formation of the GDP‐bound state.
A F, Overbeck, T R, Brtva, A D, Cox, S M, Graham, S Y, Huff, R, Khosravi-Far, L A, Quilliam, P A, Solski, C J, Der   +8 more
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Asef is a Cdc42-specific guanine nucleotide exchange factor

Biological Chemistry, 2007
Asef is a member of the Dbl-family of guanine nucleotide exchange factors (GEFs) with a proposed specificity for the small GTPase Rac1. Here we investigated the specificity and regulation of Asef by measuring its GEF activity in vitro and observed hardly any activity towards Rac1, Rac2 and Rac3, or RhoA and TC10.
Gotthardt, K., Ahmadian, M.
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GrinchGEF—A novel Rho-specific guanine nucleotide exchange factor

Biochemical and Biophysical Research Communications, 2005
RhoGTPases, which are activated by specific guanine nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. We identified a new RhoGEF (GrinchGEF) containing the typical Dbl homology domain, a putative WD40-like domain, and two predicted transmembrane helices.
Stefan, Winkler, Marion, Mohl, Thomas, Wieland, Susanne, Lutz   +3 more
openaire   +2 more sources