Ric-8A, a Gα protein guanine nucleotide exchange factor potentiates taste receptor signaling
Frontiers in Cellular Neuroscience, 2009 Taste receptors for sweet, bitter and umami tastants are G-protein coupled receptors (GPCRs). While much effort has been devoted to understanding G-protein-receptor interactions and identifying the components of the signalling cascade downstream of these
Claire J Fenech +8 more
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Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma
Molecular & Cellular Oncology, 2021 In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells.
Mariana Cooke
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Inhibition of Subsets of G Protein-coupled Receptors by Empty Mutants of G Protein α Subunits in Go, G11, and G16 [PDF]
, 2000 We previously reported that the xanthine nucleotide binding Goα mutant, GoαX, inhibited the activation of Gi-coupled receptors. We constructed similar mutations in G11α and G16α and characterized their nucleotide binding and receptor interaction.
Gu, Lingjie, Simon, Melvin I., Yu, Bo
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Research progress in the relationship between PREX1 gene and tumor pathogenesis [PDF]
Xin yixue, 2023 Phosphatidylinositol-3， 4， 5-triphosphate-dependent Rac exchange factor 1 （PREX1） is a coding gene that is abnormally expressed in a variety of tumors. As a guanine nucleotide exchange factor （RacGEF） of small GTP binding protein Rac1， PREX1 gene-encoded
Chen Ting, Zhou Yu
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An Activating Mutation in sos-1 Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during Caenorhabditis elegans Vulval Development [PDF]
, 2007 Proper regulation of receptor tyrosine kinase (RTK)-Ras-mitogen-activated protein kinase (MAPK) signaling pathways is critical for normal development and the prevention of cancer.
Elgort, Marc G. +7 more
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ARL3 mutations cause Joubert syndrome by disrupting ciliary protein composition [PDF]
, 2018 Joubert syndrome (JBTS) is a genetically heterogeneous autosomal recessive neurodevelopmental ciliopathy. We investigated further the underlying genetic etiology of Joubert syndrome by studying two unrelated families in whom JBTS was not associated ...
Alhashem, Amal +18 more
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The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms [PDF]
, 2008 © 2008 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Ammerer G. +58 more
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Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling
Cells, 2020 Coordinated actions of Rab and Rho are necessary for numerous essential cellular processes ranging from vesicle budding to whole cell movement. How Rab and Rho are choreographed is poorly understood. Here, we report a protein complex comprised of kalirin,
Xiaolong Wang +5 more
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A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes. [PDF]
, 2014 Insulin-stimulated glucose uptake in fat and muscle is mediated by the major facilitative glucose transporter Glut4. Insulin controls the trafficking of Glut4 to the plasma membrane via regulation of a series of small G proteins, including RalA and Rab10.
Chen, Xiao-Wei +6 more
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source