Results 121 to 130 of about 9,354,840 (235)
Analysis of Guanine Nucleotide Binding and Exchange Kinetics of the Escherichia coli GTPase Era
, 2000 Era is an essential Escherichia coli guanine nucleotide binding protein that appears to play a number of cellular roles.
R. R. Neubig +3 more
core +1 more source
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors. [PDF]
Small GTPases, 2022 Lawson CD +6 more
europepmc +1 more source
Mechanism of Nucleotide Exchange by Guanine Nucleotide Exchange Factors on the Ras Superfamily of Small G-Proteins [PDF]
, 2000 The Ras superfamily of small G-proteins cycle between an active GTP bound form and an inactive GDP bound form. This cycle is controlled by GTPase activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs). Sos, a GEF for Ras proteins, is a
Pickford, Christopher
core +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Zyxin signaling: Protease-activated receptor-1 and Rho guanine nucleotide exchange factor p114.
, 2009 Zyxin signaling: Protease-activated receptor-1 and Rho guanine nucleotide exchange factor ...
Jingyan. Han (7998782)
core +4 more sources
Cardiotoxicity of BRAF/MEK inhibitors
British Journal of Pharmacology, EarlyView.Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe +4 more
wiley +1 more source
Role of Rho guanine nucleotide exchange factors in non-small cell lung cancer. [PDF]
Bioengineered, 2021 Zeng RJ +9 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher +6 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu +10 more
wiley +1 more source