Results 111 to 120 of about 83,277 (241)

Structural biology of DOCK-family guanine nucleotide exchange factors. [PDF]

FEBS Lett, 2023
Boland A, Côté JF, Barford D.
europepmc   +1 more source

The RasGrf family of mammalian guanine nucleotide exchange factors

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2011
RasGrf1 and RasGrf2 are highly homologous mammalian guanine nucleotide exchange factors which are able to activate specific Ras or Rho GTPases. The RasGrf genes are preferentially expressed in the central nervous system, although specific expression of either locus may also occur elsewhere.
Fernández-Medarde, Alberto, Santos de Dios, Eugenio   +1 more
openaire   +4 more sources

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, EarlyView.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source

HPIP and RUFY3 are noncanonical guanine nucleotide exchange factors of Rab5 to regulate endocytosis-coupled focal adhesion turnover. [PDF]

J Biol Chem, 2023
Khumukcham SS, Penugurti V, Bugide S, Dwivedi A, Kumari A, Kesavan PS, Kalali S, Mishra YG, Ramesh VA, Nagarajaram HA, Mazumder A, Manavathi B.   +11 more
europepmc   +1 more source

Protein Pattern Formation

, 2018
Protein pattern formation is essential for the spatial organization of many intracellular processes like cell division, flagellum positioning, and chemotaxis.
A Desai, A Melbinger, A Touhami, A Treuner-Lange, A Varma, A-C Butty, AB Goryachev, AG Vecchiarelli, AJ Molendijk, AM Turing, B Goldstein, B Klünder, BD Corbin, D Schumacher, D Thalmeier, DA Ramirez-Diaz, David Fange, DM Raskin, DM Raskin, E Bi, E Mileykovskaya, E Munro, F Wu, Fabai Wu, FO Bendezu, G Bange, G Meacci, I Bose, IS Aranson, J Denk, J Denk, J Guckenheimer, J Halatek, J Halatek, J Halatek, J Halatek, J Lutkenhaus, J Lutkenhaus, J Männik, J Schweizer, JE Pearson, JS Schuhmacher, K Gerdes, K Zieske, K Zieske, K Zieske, K-T Park, KC Huang, KJ Lee, L Kozubowski, L Laan, L Reese, L Reese, LA Segel, LD Renner, LL Lackner, M Bonny, M Cross, M Kac, M Loose, M Loose, M Loose, M Loose, M Otsuji, MC Florian, NW Goehring, NW Goehring, NW Goehring, O Sliusarenko, P Gray, P Gray, P Gray, R Thom, R Wedlich-Soldner, RA Green, S Bergeler, S Kondo, S Kretschmer, T Freisinger, TH Szeto, V Ivanov, V Varga, V Varga, WM Bement, Y Caspi, Y Gu, Y-L Shih, Y-L Shih, Y-L Shih, Z Hu, Z Hu, Z Hu, Z Hu, Z Hu   +93 more
core   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

GPCRs that Rhoar the Guanine nucleotide exchange factors. [PDF]

Small GTPases, 2022
Omble A, Kulkarni K.
europepmc   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors. [PDF]

Small GTPases, 2022
Lawson CD, Hornigold K, Pan D, Niewczas I, Andrews S, Clark J, Welch H.   +6 more
europepmc   +1 more source