Results 141 to 150 of about 238,540 (308)

Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo [PDF]

, 2020
Qian Wang, Yi Fang Guan, Sarah E. Hancock, Kanu Wahi, Michelle van Geldermalsen, Blake K. Zhang, Angel Pang, Rajini Nagarajah, Blossom Mak, Lisa G. Horvath, Nigel Turner, Jeff Holst   +11 more
openalex   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

Two guanosine binding sites exist in group I self-splicing IVS RNAs.

, 1988
Peter S. Kay, Peter Menzel, Takuro Inoue
openalex   +2 more sources

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

Phylogeny of conserved adenines in linkers of Group-I introns [PDF]

, 2009
We have analyzed the linkers in group-I introns, a characteristic region that is crucial to the folding and splicing process of the folded RNA, in seventy sequences spreading across r-RNA, t-RNA and organelle genes from various organisms including algae,
Chandrasekhar Kesavan, Natarajan Ganesan
core   +1 more source

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

eLife
Cyclic nucleotide binding domains (CNB) confer allosteric regulation by cAMP or cGMP to many signaling proteins, including PKA and PKG. PKA of phylogenetically distant Trypanosoma is the first exception as it is cyclic nucleotide-independent and ...
Veronica Teresa Ober, George Boniface Githure, Yuri Volpato Santos, Sidney Becker, Gabriel Moya Munoz, Jérôme Basquin, Frank Schwede, Esben Lorentzen, Michael Boshart   +8 more
doaj   +1 more source

Characterization of genome-reduced Bacillus subtilis strains and their application for the production of guanosine and thymidine [PDF]

, 2016
Yang Li, Xujun Zhu, Xueyu Zhang, Jing Fu, Zhiwen Wang, Tao Chen, Xueming Zhao   +6 more
openalex   +1 more source

Synthesis, characterization, and biological activities of new conjugates of Guanosine grafted on polyvinyl alcohol, carbohydrate chitosan, and cellulose [PDF]

, 2022
Sabry El-Naggar, A. A. EL‐BARBARY, Yehia A. Hafez, Wesam M. Salama, Hazem M. Elkholy, Mohamed Mounir Shaker   +5 more
openalex   +1 more source

Modulating Taste Perception in Newly Weaned Piglets: The Role of Palatability Additives in Enhancing Feed Intake and Performance

Animal Research and One Health, EarlyView.
Palatability enhancers modulate taste and smell, increasing feed acceptance, reducing weaning stress, and improving piglet performance. ABSTRACT The continuous growth of global agribusiness stimulates the search for alternatives that can enhance the performance and quality of life of production animals.
Luana Specht, Gabriela Altenhofen, Daiane Carvalho, Michele Fangmeier   +3 more
wiley   +1 more source

The Mechanism of Guanosine Nucleotide Hydrolysis by p21 c-Ha-ras

, 1989
Juergen Feuerstein, Roger S. Goody, Martin R. Webb   +2 more
openalex   +1 more source