Results 231 to 240 of about 201,939 (380)

IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma. [PDF]

open access: yesiScience
Schnabel JL   +7 more
europepmc   +1 more source

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin   +6 more
wiley   +1 more source

Circumventing glioblastoma resistance to temozolomide through optimal drug combinations designed by systems pharmacology and machine learning

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Glioblastoma (GBM), the most frequent and aggressive brain tumour in adults, is associated with a dismal prognostic despite intensive treatment involving surgery, radiotherapy and temozolomide (TMZ)‐based chemotherapy. The initial or acquired resistance of GBM to TMZ appeals for precision medicine approaches to the design of ...
Sergio Corridore   +6 more
wiley   +1 more source

How to recover from a bad start: adaptation of HIV-1 transcription start site mutants during serial passaging in culture. [PDF]

open access: yesJ Virol
Nikolaitchik OA   +7 more
europepmc   +1 more source

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