Results 241 to 250 of about 163,448 (315)

Guanine nucleotide directed co-assembly with Pt-complexes for tailoring chiroptical properties and multimodal molecular recognition. [PDF]

Chem Sci
Xiao J, Zeng F, Luo ZW, Yang B, Song J, Duan P, Jin X, Chen Y, Yu ZQ.   +8 more
europepmc   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Novel Pyrido[4,3‑<i>d</i>]pyrimidine Derivatives as Kirsten Rat Sarcoma (KRAS) G12C Potential Inhibitors. [PDF]

ACS Med Chem Lett
Song R, Liang SH.
europepmc   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities. [PDF]

Protein Sci
Taherian F, Mabanglo MF, Hajian T, Tucker S, Kalinic E, Perveen S, Aman A, Vedadi M.   +7 more
europepmc   +1 more source

Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants

The FEBS Journal, EarlyView.
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan, Jafar S. Jabbari, Naomi X. L. Ling, Anne M. Kong, Jia Q. Truong, Marnie L. Maddock, Ayeshah A. Rosdah, Christopher G. Langendorf, Lifang Zhang, Jarmon G. Lees, Sebastian Bass‐Stringer, Danise Ann Onda, Alice Pébay, Mirella Dottori, Kim Loh, Jessica K. Holien, Sean Lal, Nadia M. Davidson, Jonathan S. Oakhill, Shiang Y. Lim   +19 more
wiley   +1 more source

In the <i>IMD2</i> gene of <i>Saccharomyces cerevisiae</i>, the expression memory suppresses the induction of expression during guanosine triphosphate depletion. [PDF]

PNAS Nexus
Yokosawa T, Ayano T, Oki M.
europepmc   +1 more source

Protective effects of extracellular vesicle‐like nanoparticles derived from Cannabis sativa adventitious roots against UVB‐induced damage in human keratinocytes

International Journal of Cosmetic Science, EarlyView.
Cannabis sativa root‐derived extracellular vesicle‐like nanoparticles (CA‐NPs) were isolated from adventitious root cultures and subjected to physicochemical characterization. Upon UVB exposure, keratinocytes exhibited increased ROS generation, apoptosis and MAPK activation, leading to oxidative stress and skin damage.
Dong Ho Bak, Su Hyun Park, Young Bae Ryu, Cha Young Kim, Jae Cheol Jeong, Woo Sik Kim   +5 more
wiley   +1 more source

Identification and functional verification of key genes involved in alkaloid biosynthesis in <i>Pinellia ternata</i>. [PDF]

Front Plant Sci
Pei Y, Wang Z, Chen C, Xu N, Shen C, Sun Y, Wang S.   +6 more
europepmc   +1 more source